The special features of early diagnosis of nonstreptococcus tonsillopharyngitis in children
DOI:
https://doi.org/10.15587/2313-8416.2016.59270Keywords:
Children, tonsillopharyngitis, streptotest, beta-hemolytic streptococcus, MacIsaak scale, interleikin-6, interleikin-8Abstract
There was studied an expediency and diagnostic value of using an intensity of clinical symptoms, general blood analysis, interleikin-6 and -8 content in the blood serum for the early diagnostics of the acute nonstreptococcus tonsillopharyngites in children. The aim of the work was to study the diagnostic value of the general clinical and paraclinical indicators in verification of nonstreptococcus etiology of acute tonsillopharyhgites in children and for optimization of its treatment.
Methods. There were examined 98 patients with acute tonsillopharyngites: 66 persons with nonstreptococcus etiology and 32 children with diagnosis “acute streptococcus tonsillopharyngitis”. The streptococcus etiology was proved by the positive result of cultural study of throat swab. As auxiliary paraclinical criteria of confirmation of nonstreptococcus etiology of ATP in patients of comparison group were analyzed the indices of general blood analysis and interleikin-6 (IL-6) and IL-8 content in the blood serum.
Results. The intensity of clinical symptoms that were assessed on MacIsaac scale and indices of the general blood analysis cannot be used independently for the early diagnostics of ATP of nonstreptococcus etiology because of insufficient sensitivity of these methods. The development of acute nonstreptococcus tonsillopharyngitis in children is attended with the normal indices of interleikin-6 concentration and the lowered interleikin-8 content in the blood serum.
Conclusions. To determine the tactics of starting treatment in children with symptoms of acute tonsillopharyngitis it can be used the next clinical and paraclinical complex: the general sum of points on MacIsaac scale, interleikin-6 level, and IL-8 content in the blood serum. An increase of IL-6 level and decrease of IL-8 content in the blood serum of patients with acute tonsillopharyngitis increases more than twice the detection of nonstreptococcus etiology of disease in children
References
Lasseter, G. M., McNulty, C. A., Richard Hobbs, F., Mant, D., Little, P. (2009). In vitro evaluation of five rapid antigen detection tests for group A beta-haemolytic streptococcal sore throat infections. Family Practice, 26 (6), 437–444. doi: 10.1093/fampra/cmp054
Izvin, A. I., Kataeva, L. V. (2009). Mikrobnyiy peyzazh slizistoy obolochki verhnih dyihatelnyih putey v norme i patologi [Microbial Landscape of the mucous membrane of the upper respiratory tract in health and disease]. Vestnik otorinolaringologii, 2, 64–68.
Krivopustov, S. P. (2010). Ostryiy tonzilofaringit u detey: voprosyi differentsialnoy dIagnostiki i lecheniya [Acute tonsillopharingytis in children: Questions of differential diagnostic and treatment]. Zdorove rebenka, 1 (22), 94–98.
Nagornaya, N. V., Bordyugova, E. V., Koval, A. P. (2013). Ostryiy streptokokkovyiy tonzillit u rebenka. voprosyi, zadannyie zhiznyu (otvetyi nauki na voprosyi, zadannyie praktikoy) [Acute streptococcal tonsillitis in children. the questions posed by life (science answers to questions posed by the practice)]. Zdorove rebenka, 8 (51), 115–120.
Dewhirst, F. E., Chen, T., Izard, J., Paster, B. J., Tanner, A. C. R., Yu, W.-H. et. al (2010). The Human Oral Microbiome. Journal of Bacteriology, 192 (19), 5002–5017. doi: 10.1128/jb.00542-10
Lopatin, A. S. (2001). Lechenie ostrogo i hronicheskogo faringita [Treatment of acute and chronic pharyngitis]. RMZh, 9 (16-17), 765–769.
Luchsheva, Yu. V., Izotova, G. N. (2011). Mestnaya terapiya pri faringite [Local therapy for sore throat]. RMZh, 19 (6), 420–426.
Pluzhnikov, M. S., Panova, N. V., Levin, M. Ya.; Pluzhnikov, M. S. (Ed.) (2006). Faringit (kliniko-morfologicheskie aspektyi i kriohirurgiya) [Pharyngitis (clinical and morphological aspects and cryosurgery)]. Sankt-Peterburg: Dialog, 120.
Dvoretskiy, L. I., Yakovlev, S. V. (2003). Oshibki v antibakterialnoy terapii infektsionnyih zabolevaniy dyihatelnyih putey v ambulatornoy praktike [Errors in antibacterial therapy of infectious diseases of the respiratory tract in ambulatory practice]. Lechaschiy vrach, 8, 34–37.
Yulish, E. I., Chernyishova, O. E., Krivuschev, B. I. et. al (2013). Ostryiy streptokokkovyiy tonzilofaringit u detey: voprosyi diagnostiki i terapii [Acute streptococcal tonsillopharingitis in children: questions of diagnostics and therapy]. Zdorove rebenka, 4 (47), 79–82.
Chen, T., Yu, W.-H., Izard, J., Baranova, O. V., Lakshmanan, A., Dewhirst, F. E. (2010). The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information. Database, 2010 (0), baq013–baq013. doi: 10.1093/database/baq013
Dvoretskiy, L. I., Yakovlev, S. V. (2003). Oshibki v antibakterialnoy terapii infektsionnyih zabolevaniy dyihatelnyih putey v ambulatornoy praktike [Errors in antibacterial therapy of infectious diseases of the respiratory tract in outpatients]. Lechaschiy vrach, 8, 34–37.
Egorova, O. A. (2006). Tselesoobraznost primeneniya mestnyih antimikrobnyih preparatov pri lechenii infektsiy verhnih dyihatelnyih putey [The feasibility of the use of local antimicrobial agents in the treatment of upper respiratory tract infections]. Farmateka, 5, 107–109.
Kozlov, R. S. (2006). Klinicheskaya mikrobiologiya [Clinical Microbiology]. Antimikrobnaya himioterapiya, 8, 33–47.
Ryabova, M. A. (2010). Bol v gorle – vsegda li zabolevanie verhnih dyihatelnyih putey? [Sore throat – there is always a disease of the upper respiratory tract?]. Spravochnik poliklinicheskogo vracha, 1, 32–37.
Samsyigina, G. A. (2008). Ostryiy tonzillofaringit u detey [Acute tonsillopharingitis in children]. Pediatriya, 87 (3), 91–95.
Feschenko, Yu. I., Pertseva, T. A., Mostovoy, Yu. M. (2007). Natsionalnyiy kongress po antibiotikoterapii: v tsentre vnimaniya – zaschitnyie aminopenitsillinyi [National Congress of antibiotic therapy: focus – safety aminopenicillins]. Zdorov'ya Ukrayiny`, 22, 41–45.
Shpyinev, K. V., Krechikov, V. A. (2007). Sovremennyie podhodyi k diagnostike streptokokkovogo faringita [Modern approaches to the diagnosis of streptococcal pharyngitis]. KMAH, 9, 20–33.
Passali, D., Damiani, V., Passali, G. C., Passali, F. M., Boccazzi, A., Bellussi, L. (2004). Structural and Immunological Characteristics of Chronically Inflamed Adenotonsillar Tissue in Childhood. Clinical and Vaccine Immunology, 11 (6), 1154–1157. doi: 10.1128/cdli.11.6.1154-1157.2004
Polunin, M. M., Titarova, L. S., Polunina, T. A. (2012). Streptokokkovyiy tonzillit u detey [Streptococcal tonsillitis in children]. Pediatricheskaya farmakologiya, 9 (3), 19–21.
Scheller, J., Chalaris, A., Schmidt-Arras, D., Rose-John, S. (2011). The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research, 1813 (5), 878–888. doi: 10.1016/j.bbamcr.2011.01.034
Astrauskienė, D. (2008). Recurrent tonsillitis in children’s rheumatic arthritides: a review. Acta medica lituanica, 15 (4), 194–198. Available at: http://www.lmaleidykla.lt/publ/1392-0138/2008/4/194-198.pdf
Downloads
Published
Issue
Section
License
Copyright (c) 2016 Уляна Іванівна Марусик, Лорина Алімівна Іванова, Інна Борисівна Горбатюк
![Creative Commons License](http://i.creativecommons.org/l/by/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.
Authors, who are published in this journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.