Cortisol/DHEA ratio and the rates of blood serum lipid profile in patients with diabetes mellitus type 2 with different visceral adiposity index
DOI:
https://doi.org/10.15587/2313-8416.2016.59277Keywords:
visceral adiposity index, diabetes mellitus type 2, lipid spectrum, cortisol, DHEAAbstract
Aim of the work. To determine the possibility of using visceral adiposity index (VAI) for diagnostics of the lipid metabolism disorders and corticosteroid balance in patients with diabetes mellitus type 2 (DM2).
Methods. In 19 patients with diabetes mellitus type 2older than 50 years old were detected body mass, height, waist size, blood serum lipid spectrum (triglycerides LPHD), were calculated body mass index (BMI), VAI, cortisol/ dehydroeipandrosterone (DHEA) ratio.
Results. The examined patients were divided into 3 groups (tertiles) on VAI rate. An increase of VAI tertile was attended by the changes of blood serum lipid spectrum (increase of TG levels and decrease of LPHD, increase of LPVLD). The changes of lipid rates in I-III tertiles on VAI level did not depend on BMI rates and waist size (WS) as indicators of the general and abdominal adiposity respectively, on the contrary in III group there was fixed an increase of hypodermic adipose plica. There was not revealed an increase of C-peptide concentration (insulin secretion characteristics). An increase of VAI value in patients with DM2 was also attended with unfavorable quantitative changes of corticosteroid concentration namely an increase of cortisol level and decrease of DHEA-C (DHEA-sulfate) level. In groups of patients with low and high VAI there was revealed the different character of correlative interconnection between VAI value and cortisol, DHEA-C levels, cortisol/DHEA ratio that is: the direct (physiological) correlation detected in the conditions of the low VAI was changed into an opposite one in patients with the high VAI that demonstrated the disturbance of the balance between cortisol and DHEA that must to counterpoise one another in the normal conditions.
Conclusion. VAI is the more sensitive indicator for assessment of the general and abdominal adiposity parameters and the lipid spectrum rates comparing with BMI and WS. VAI value demonstrated an interconnection with disturbance of cortisol/DHEA ratio and LPVLD levels that indicates the possibility of using VAI and cortisol/DHEA coefficients for assessment of the disturbance of lipid balance and corticosteroid balance in patients with DM2
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Copyright (c) 2016 Наталія Миколаївна Кушнарева, Вадим Валерійович Корпачев, Олеся Вадимівна Корпачева-Зінич, Наталія Марківна Гуріна, Ольга Володимирівна Прибила
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