Development and study of the gel with burdock extract for dermatological application

Authors

  • Євгеній Володимирович Гладух National University of Pharmacy 53 Pushkinskaya str., Kharkiv, Ukraine, 61002, Ukraine
  • Анан Марсель Сегі National University of Pharmacy 53 Pushkinskaya str., Kharkiv, Ukraine, 61002, Ukraine
  • Ніна Олексіївна Ніколайчук National University of Pharmacy 53 Pushkinskaya str., Kharkiv, Ukraine, 61002, Ukraine
  • Шматенко Валентинівна Вікторія Ukrainian military medical academy 24 Melnikova str., Kyiv, Ukraine, 04655, Ukraine

DOI:

https://doi.org/10.15587/2313-8416.2016.61442

Keywords:

burdock leaves extract, gel, hydroxymethyl cellulose, structural and mechanical properties, release, flavonoids

Abstract

Aim. To carry out research on development of composition of the soft dosage form with burdock thick extract for dermatological application.

Methods. For the bioavailability estimation of the soft dosage forms model samples, in vitro release of flavonoids has been studied by the methods of dialysis across semi-permeable membranes and diffusion in 6% gelatin gel. Structural and mechanical properties of the developed gel has been studied by using rotational viscometer «Rheolab QC» («Anton Paar», Austria) with coaxial cylinders CC27/S-SN29766.

Results. It has been shown that the hydroxymethyl cellulose-based gel model sample had the highest release of flavonoids. The structural and mechanical properties of the gel base proved the presence of a non-Newtonian flow type with plastic and thixotropic properties of the developed remedy. The calculated mechanical stability value allows predict stability at homogenization and storage of the medicinal product.

Conclusion. The composition and technology of the hydroxymethyl cellulose-based gel with burdock extract have been developed, as well as its biopharmaceutical parameters have been determined

Author Biographies

Євгеній Володимирович Гладух, National University of Pharmacy 53 Pushkinskaya str., Kharkiv, Ukraine, 61002

Doctor of Pharmacy, professor, head of department

Department of Industrial Pharmacy

Анан Марсель Сегі, National University of Pharmacy 53 Pushkinskaya str., Kharkiv, Ukraine, 61002

Department of Industrial Pharmacy

Ніна Олексіївна Ніколайчук, National University of Pharmacy 53 Pushkinskaya str., Kharkiv, Ukraine, 61002

Candidate of Pharmaceutical Sciences, Associate Professor

Department of Industrial Pharmacy

Шматенко Валентинівна Вікторія, Ukrainian military medical academy 24 Melnikova str., Kyiv, Ukraine, 04655

Associate professorDepartment of military pharmacy

References

Dautov, F. F., Hakimova, R. F., Jusupova, N. Z. et. al (2009). Allergicheskaja zabolevaemost' detskogo naselenija goroda s razvitoj neftehimicheskoj promyshlennost'ju. Gigiena i sanitarija, 3, 54–57.

Mavljanov, I. R., A. Kasymov, Sh., Mavljanov, Z. I., Karimova, N. M. et. al (2010). Allergicheskie oslozhnenija na lekarstva i sezonnaja harakteristika ih vstrechaemosti. Vestnik vosstanovitel'noj mediciny. Diagnostika. Ozdorovlenie. Reabilitacija: organ Associacii specialistov vosstanovitel'noj mediciny, 5, 68–71.

Dorner, T., Lawrence, K., Rieder, A., Kunze, M. (2007). Epidemiology of allergies in Austria. Results of the first Austrian Allergy Report. Wiener Medizinische Wochenschrift, 157 (11-12), 235–242. doi: 10.1007/s10354-007-0419-5

Garn, H., Renz, H. (2007). Epidemiological and immunological evidence for the hygiene hypothesis. Immunobiology, 212 (6), 441–452. doi: 10.1016/j.imbio.2007.03.006

Butko, Ja. A. (2007). Farmakokorrekcija ranevogo processa. Provіzor, 15, 26–32.

Gladuh, Je. V., Segi, A. M. (2015). Vybir osnovy pry stvorenni mazi z gustym ekstraktom lystja lopuha. Kyiv, 122–125.

Segi, A. M., Nikolajchuk, N. A. (2015). Izuchenie processa jekstrakcii list'ev lopuha. Vladikavkaz, 233–236.

Segi, A. M., Nikolajchuk, N. A. (2015). Poluchenie jekstrakta list'ev lopuha. Recept, 6 (104), 59–63.

Gladukh, Ie. V., Seguy, A. M. (2016). The study of pharmacotechnological parameters of burdock (Arctium lappa) leaves. Journal of Chemical and Pharmaceutical Research, 8 (1), 260–264. Available at: http://jocpr.com/vol8-iss1-2016/JCPR-2016-8-1-260-264.pdf

Derzhavna Farmakopeja Ukrai'ny (2008). Derzhavne pidpryjemstvo «Naukovo-ekspertnyj farmakopejnyj centr». Kharkiv: RIREG, 85–101.

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Published

2016-03-15

Issue

Vol. 2 No. 4 (19) (2016)

Section

Pharmaceutical Sciences

License

Copyright (c) 2016 Євгеній Володимирович Гладух, Анан Марсель Сегі, Ніна Олексіївна Ніколайчук, Шматенко Валентинівна Вікторія

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