Gene regulation of telomere length in human peripheral blood lymphocytes in early and remote perods after irradiation

Authors

  • Ірина Миколаївна Ільєнко SI “National Research Center for Radiation Medicine NAMS of Ukraine” 53 Melnikova str., Kyiv, Ukraine, 04050, Ukraine
  • Димитрій Анатолійович Базика SI “National Research Center for Radiation Medicine NAMS of Ukraine” 53 Melnikova str., Kyiv, Ukraine, 04050, Ukraine

DOI:

https://doi.org/10.15587/2313-8416.2016.63344

Keywords:

gene expression, TERF1, TERF2, TERT, telomere, ionizing radiation, Chernobyl, "Shelter" object

Abstract

Radiation-associated violations of gene regulation of lymphocytes telomere length in early and late period after exposure are investigated. In Chernobyl clean-up workers in the range of doses more than 500 mSv was set reduction of relative telomere length and imbalance in TERF1, TERF2 gene expression on the background of p53-mediated activation of telomerase activity. The early period after professional exposure in“Shelter” object characterized by impairment of protective function of telomeres

Author Biographies

Ірина Миколаївна Ільєнко, SI “National Research Center for Radiation Medicine NAMS of Ukraine” 53 Melnikova str., Kyiv, Ukraine, 04050

PhD, Senior Researcher

Laboratory of immune cytology, Department of Clinical Immunology 

Димитрій Анатолійович Базика, SI “National Research Center for Radiation Medicine NAMS of Ukraine” 53 Melnikova str., Kyiv, Ukraine, 04050

Corresponding Member of National Academy of Medical Sciences of Ukraine, Medical Doctor, Professor

General Director of SI “National Research Center for Radiation Medicine NAMS of Ukraine”

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Published

2016-03-27

Issue

Vol. 3 No. 1 (20) (2016)

Section

Biological sciences

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Copyright (c) 2016 Ірина Миколаївна Ільєнко, Димитрій Анатолійович Базика

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