The problem of radiogenic thyroid cancer
DOI:
https://doi.org/10.15587/2313-8416.2015.37682Keywords:
ionizing radiation, Chernobyl accident, genetic instability, thyroid, radiogenic cancerAbstract
Aim. Analysis and compilation of radiation-epidemiological and radiobiological researches showing that exposure is the cause of radiogenic thyroid cancer.
Methods. Radiation-epidemiological, cytogenetic, experimental.
Results. Data analysis of numerous investigations confirms that the thyroid gland belongs to the group of high risk of cancer developing of radiation genesis. The significant differences in the quantitative risk assessment of thyroid cancer of radiation genesis in different populations, irradiated by the Chernobyl accident, are revealed. Iodine deficiency is considered as an effective promoter of radiation carcinogenesis. Attention is focused on the fact that environmental pollution, combined with the increased sensitivity of the epithelium of the thyroid gland to radiation can serve as the basis for a continuing trend towards a higher incidence thyroid cancer in the future.
Conclusions. Analysis and compilation of epidemiological and radiobiological investigations clearly indicate that ionizing radiation is the causative factor in the production of radiogenic thyroid cancer. The current radioecological situation in Ukraine necessitate the need to develop and implement effective strategies for primary prevention of radiogenic cancer at the individual level
References
Kovalenko, A. N., Afanas'ev, D. E., Samojlova, A. A. (2006). Vvedenie v radiacionnuju tireoidologiju. Kiev: Tomiris-N, 616.
Baleva, L. S., Jakovleva, I. N., Karahan, N. M., Danilycheva, L. I. (2012). Radiacionno-inducirovannaja patologija shhitovidnoj zhelezy u grazhdan, podvergshihsja vozdejstviju radiacii v rezul'tate avarii na ChAJeS vo vnutriutrobnom, detskom i podrostkovom vozraste. Mater. Mezhdunar. konf. «Mediko-biologicheskie problemy dejstvija radiacii». Moscow: FGU FMBC Rossii, 108.
Grinevich, Ju. A., Chumak, A. A. (Eds.) (2011). Rak shhitovidnoj zhelezy. Kiev: Zdorov’ja, 208.
De Grool, L. J. (1979). Thyroid neoplasia. Endocrinology. New York, 521.
Shigematsu, I., Kamada, I., Akiyama, M., Sasaki, H. (1995). Effects of A-Bomb Radiation n the Body. Tokyo: University, 419.
Nagataki, S.; Thomas, G., Karaoglou, A., Williams, E. D. (Eds.) (1999). Atomic Bomb Survivors population. In: Radiation and Thyroid Cancer. Singapore: World Scientifio, 35–40.
Prentice, R. L., Yoshmoto, Y., Mason, M. W. (1983). Relationship of cigarette smoking and radiation exposure to cancer mortality in Hiroshima and Nagasaki. J. Nat. Cancer Inst., 70 (4), 611–622.
Ezaki, H., Ishimaru, T., Hayashi, Y., Takeichi, N. (1986). Cancer of the Thyroid and Salivary Glands. Cancer in Atomic Bomb Survivors, 32, 129–142. doi:10.1007/978-1-4613-2257-3_9
Shimizu, Y., Kato, H., Schull, W. J. (1991). Risk of Cancer among Atomic Bomb Survivors. Journal of Radiation Research, 32 (2), 54–63. doi:10.1269/jrr.32.supplement2_54
Hamilton, T. E., Van Belle, G., LoGerfo, J. P. (1987). Thyroid neoplasia in Marshall Islanders exposed to nuclear fallout. JAMA: The Journal of the American Medical Association, 258 (5), 629–635. doi:10.1001/jama.258.5.629
Dobyns, B. M., Hyrmer, B. A. (1992). The surgical management of benign and malignant thyroid neoplasms in marshall islanders exposed to hydrogen bomb fallout. World Journal of Surgery, 16 (1), 126–139. doi:10.1007/bf02067128
Lessard, E. T., Brill, A. B., Adams, W. H. (1989). Thyroid cancer in the Marshallese: relative risk of short-lived internal emitters and external radiation exposure. Preprint BNI. 37335 Brookhaven Nat. Lab., 23.
Uderzo, C., van Lint, M. T., Rovelli, A., Weber, G., Castellani, M. R., Bacigalupo, A. et. al. (1994). Papillary thyroid carcinoma after total body irradiation. Archives of Disease in Childhood, 71 (3), 256–258. doi:10.1136/adc.71.3.256
Schneider, A. B., Shore-Freedman, E., Weinstein, R. A. (1985). Radiation-induced tumors of the head and neck following childhood irradiation. Prospective studies. Medicine, 64 (1), 1–15. doi: 10.1097/00005792-198501000-00001
Inskip, P. D., Ekbom, A., Galanti, M. R., Grimelius, L., Boice, J. D. (1995). Medical Diagnostic X Rays and Thyroid Cancer. JNCI Journal of the National Cancer Institute, 87 (21), 1613–1621. doi:10.1093/jnci/87.21.1613
Bessho, F., Ohta, K., Akanuma, A., Sakata, K. (1994). Dosimetry of Radiation Scattered to Thyroid Gland from Prophylactic Cranial Irradiation for Childhood Leukemia. Pediatric Hematology-Oncology, 11 (1), 47–53. doi:10.3109/08880019409141900
Shore, R. E. (1985). Thyroid tumors following thymus irradiation. J. Nat. Cancer Inst., 74 (6), 1177–1184.
Fogelfeld, L., Wiviott, M. B. T., Shore-Freedman, E., Blend, M., Bekerman, C., Pinsky, S., Schneider, A. B. (1989). Recurrence of Thyroid Nodules after Surgical Removal in Patients Irradiated in Childhood for Benign Conditions. New England Journal of Medicine, 320 (13), 835–840. doi:10.1056/nejm198903303201304
Tsyb, A. F. (Ed.) (1996). Healts Consequences of the Chernobyl Accident. Results of the IPHECA Pilot Projects and Related National Programmes. Scientific Report. Geneva: World Health Organization, Geneva, 520.
Astakhova, L. N., Anspaugh, L. R., Beebe, G. W., Bouville, A., Drozdovitch, V. V., Garber, V. et. al. (1998). Chernobyl-Related Thyroid Cancer in Children of Belarus: A Case-Control Study. Radiation Research, 150 (3), 349. doi: 10.2307/3579983
Romanenko, A. Ye., Nyagu, A. L., Loganovsky, K. N., Bazyka, D. A. (2000). Radiation medicine in an assessment of the consequences of the Chernobyl disaster. Intern. J. Radiat. Med., 1 (5), 3–25.
Nagataki, S., Hirayi, H., Izumi, M. (1989). High prevalence of thyroid nodule in area of radioactive fallout, Lancet, 289 (3), 385–386. doi: 10.1016/s0140-6736(89)90562-x
Tron'ko, M. D., Bogdanova, T. I., Komisarenko, I. V. (2011). Rak shhytovydnoi' zalozy v Ukrai'ni pislja Chornobyl's'koi' katastrofy (25-richnyj dosvid sposterezhennja). Mater. Mezhdunar. konf. «Dvadcat' pjat' let Chernobil'skoj katastrofi. Bezopasnost' budushhego». Kiev, 309–312.
Saenko, V., Ivanov, V., Tsyb, A., Bogdanova, T., Tronko, M., Demidchik, Y., Yamashita, S. (2011). The Chernobyl Accident and its Consequences. Clinical Oncology, 23 (4), 234–243. doi:10.1016/j.clon.2011.01.502
Kindzel'skij, L. P., Zverkova, A. S., Sivkovich, S. A., Domina, E. A. (2002). Ostraja luchevaja bolezn' v uslovijah Chernobyl'skoj katastrofy. Kiev: Teleoptik, 223.
Lihtarjov, I. A., Kajro, N. A., Shpak, V. M. (1999). Radiacionno-inducirovannyj i spontannyj rak shhitovidnoj zhelezy u detej Ukrainy (dozimetricheskaja interpretacija). Mezhdunar. zhurn. radiac. med., 3-4, 51–66.
Pilins'ka, M. A., Dybs'kyj, S. S., Dybs'ka, O. B., Pedan, L. R. (2003). Rezul'taty cytogenetychnogo obstezhennja ditej, jaki meshkajut' na kontaminovanij radionuklidamy terytorii' zony zobnoi' endemii' Rivnens'koi' oblasti Ukrai'ny. Cytologyja y genetyka, 37 (3), 55–60.
Pilinskaya, M. A., Dibskiy, S. S., Shemetun, Y. V., Dibskaya, Y. B. (2005). Chromosome instability in children with thyroid pathology born to irradiated parents due Chernobyl accident. European Society of Human Genetics Conference, Prague, 13 (1), 146.
Tronko, M. K., Bogdanova, T. A., Komissarenko, I. V. (1999). Thyroid carcinoma in children and adolescents in Ukraine after the Chernobyl accident: statistical data and clinico-morphologic characteristics. Cancer, 86 (1), 149–156. doi: 10.1002/(sici)1097-0142(19990701)86:1<149::aid-cncr21>3.0.co;2-a
Malko, M.; Imanaka, T. (Ed.) (2002). Chernobyl radiation-induced thyroid cancers in Belarus. Recent Research Activities about Chernobyl NPP Accident in Belarus, Ukraine and Russia. Kyoto, 240–255.
Prysyazhnyuk, A. Ye., Romanenko, A. Ye., Grystchenko, V. G. (2004). Solid cancer and thyroid cancer in the most affected territories of Ukraine after the Chernobyl accident. International workshop on «The French-German Initiative: Results and Their Implication for Man and Environment». Kiev, 35–36.
Prysjazhnjuk, A. Je., Romanenko, A. Ju., Kajro, I. S. (2004). Ryzyk rozvytku raku shhytovydnoi' zalozy u pidlitkiv i doroslyh, jaki prozhyvajut' na terytorijah Ukrai'ny z najbil'shymy integral'nymy opadamy radiojodu vnaslidok avarii' na ChAES. Social'ni ryzyky, kn. 2. Kiev, 207–219.
Nikiforov, Y. E., Nikiforova, M., Fagin, J. A. (1998). Prevalence of minisatellite and microsatellite instability in radiation-induced post-Chernobyl pediatric thyroid carcinomas. Oncogene, 17 (15), 1983–1988. doi:10.1038/sj.onc.1202120
Richter, H. E. (1999). Microsatellite instability and loss of heterozygosity in radiation-associated thyroid carcinomas of Belarussian children and adults. Carcinogenesis, 20 (12), 2247–2252. doi:10.1093/carcin/20.12.2247
Petin, V. G., Zhurakovskaja, G. P., Komarova, L. N. (2012). Radiobiologicheskie osnovy sinergicheskih vzaimodejstvij v biosfere. Moscow: GEOS, 220.
Kanno, J., Onodera, H., Furuta, K., Maekawa, A., Kasuga, T., Hayashi, Y. (1992). Tumor-Promoting Effects of Both Iodine Deficiency and Iodine Excess in the Rat Thyroid. Toxicologic Pathology, 20 (2), 226–235. doi:10.1177/019262339202000209
Shakhtarin, V. V., Tsyb, A. F., Stepanenko, F. F. (1999). Iodine deficiency and thyroid cancer morbidity following the accident at the Chernobyl power plant. Radiation and Thyroid Cancer. Singapure, New Jersey, London, Hong Kong: Word Scientific, 277-282.
Domina, E. A. (2008). Cytogenetychni efekty v somatychnyh klitynah hvoryh na rak shhytopodibnoi' zalozy. Visnyk Ukr. tovarystva genetykiv i selekcioneriv, 6 (1), 52–59.
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