Lactic acidosis in pediatric sepsis
DOI:
https://doi.org/10.15587/2313-8416.2015.37901Keywords:
children, sepsis, severe sepsis, septic shock, multiple organ dysfunction syndrome, lactate, nitric oxide, endothelin, microcirculation, hemodynamicsAbstract
Aim. To determine the leading mechanisms of lactic acidosis course it is conducted a detailed analysis of scientific papers on this issue, and on the basis of modern scientific basis to conduct the study of the state of hemodynamics, metabolism and acid-base balance in pediatric sepsis.
Methods. To achieve this aim it was used to identify indicators of central and organ hemodynamics by Doppler ultrasound, were studied the ABB indicators of central venous and arterial blood electrolytes, creatinine, urea, lactate, endothelin, serum metabolites of nitric oxide. SOFA and Glasgow scales are used.
Result. The results of the study gave reason to believe that lactic acidosis in pediatric sepsis is not caused by disorders of the central and organ (liver, mesenteric, renal) hemodynamics. Instead it is revealed the relationship between course of lactic acidosis and presence of hyperglycemia. A negative impact of lactic acidosis on the severity of multiple organ dysfunction syndrome (MODS) and outputs in pediatric sepsis is stated.
Conclusions. Thus, summing up the results obtained in the study, we conclude that hyper lactic acidosis in pediatric sepsis is an important marker for disorders of energy metabolism and an independent marker of unfavorable prognosis and a high risk of MODS.
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