Analysis of the research methods of compounds in the exhaled air

Authors

  • Артур Олександрович Запорожець Institute of Engineering Thermophysics of NASU 2a Zhelyabova str., Kyiv, Ukraine, 03057, Ukraine https://orcid.org/0000-0002-0704-4116
  • Анастасія Дмитрівна Свердлова National Aviation University 1 Komarova ave., Kyiv, Ukraine, 03680, Ukraine

DOI:

https://doi.org/10.15587/2313-8416.2015.56679

Keywords:

gas analysis, molecule biomarkers, marker gases, exhaled air, diagnostics, methods, sensors

Abstract

The peculiarities of traces detecting of gaseous molecules in human exhaled air are considered in the article. The classification of basic physical and chemical methods of molecule biomarker analysis in exhaled air is performed. Advantages and disadvantages of considered methods are formulated. The methods of low sensitive gas analysis are analyzed and potential method for developing the portable analyzer of exhaled air is identified

Author Biographies

Артур Олександрович Запорожець, Institute of Engineering Thermophysics of NASU 2a Zhelyabova str., Kyiv, Ukraine, 03057

Postgraduate student, junior researcher

Heat measurement, diagnostics and optimization in the energy department

Анастасія Дмитрівна Свердлова, National Aviation University 1 Komarova ave., Kyiv, Ukraine, 03680

Department of Electronics

References

Pauling, L., Robinson, A. B., Teranishi, R., Cary, P. (1971). Quantitative Analysis of Urine Vapor and Breath by Gas-Liquid Partition Chromatography. Proceedings of the National Academy of Sciences, 68 (10), 2374–2376. doi: 10.1073/pnas.68.10.2374

Stepanov, E. (2009). Diodnaja lazernaja spektroskopija i analiz molekul-biomarkerov. Moscow: Fizmatlit, 416.

Phillips, M. (1992). Breath Tests in Medicine. Scientific American, 267 (1), 74–79. doi: 10.1038/scientificamerican0792-74

Phillips, M., Herrera, J., Krishnan, S., Zain, M., Greenberg, J., Cataneo, R. N. (1999). Variation in volatile organic compounds in the breath of normal humans. Journal of Chromatography B: Biomedical Sciences and Applications, 729 (1-2), 75–88. doi: 10.1016/s0378-4347(99)00127-9

Le Marchand, L., Wilkens, L. R., Harwood, P., Cooney, R. V. (1992). Use of breath hydrogen and methane as markers of colonic fermentation in epidemiologic studies: circadian patterns of excretion. Environmental Health Perspectives, 98, 199–202. doi: 10.1289/ehp.9298199

Hamilton, L. (1998). Breath Tests and Gastroenterology. Milwaukee: QuinTron Instrument Co, 123.

Coburn, R. F., Williams, W. J., Kahn, S. B. (1966). Endogenous carbon monoxide production in patients with hemolytic anemia. Journal of Clinical Investigation, 45 (4), 460–468. doi: 10.1172/jci105360

Tiunov, A., Kustov, V. (1980). Produkty metabolizma pri radiacinnom porazhenii. Moskva: Atomizdat, 104.

Gustafsson, L. E., Leone, A. M., Persson, M. G., Wiklund, N. P., Moncada, S. (1991). Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochemical and Biophysical Research Communications, 181 (2), 852–857. doi: 10.1016/0006-291x(91)91268-h

Alving, K., Weitzberg, E., Lundberg, J. (1993). Increased amount of nitric oxide in exhaled air of asthmatics. Eur. Respir. J., 6, 1368–1370.

Vaks, V., Domradcheva, E., Sobakinskaja, E., Chernjaeva, M. (2014). Analiz vydyhaemogo vozduha: fizicheskie metody, pribory i medicinskaja diagnostika. Uspehi Fizicheskih Nauk, 184, 739–758.

Stepanov, E. (2005). Metody vysokochuvstvitel'nogo gazovogo analiza molekul-biomarkerov v issledovanija vydyhaemogo vozduha. Trudy Instituta Obshhej Fiziki im. A. M. Prohorova, 67, 5–47.

Vreman, H., Stevenson, D. (1994). Semiportable electrochemical instrument for determining carbon monoxide in breath. Clin. Chem., 10, 1927–1933.

Pelli, M. A., Trovarelli, G., Capodicasa, E., De Medio, G. E., Bassotti, G. (1999). Breath alkanes determination in ulcerative colitis and Crohnʼs disease. Diseases of the Colon & Rectum, 42 (1), 71–76. doi: 10.1007/bf02235186

Hmel'nickij, R., Brodskij, E. (1984). Hromato-mass-spektrometrija. Moskva: Himija, 216.

Esterbauer, H. (1996). Estimation of peroxidative damage. A critical review. Pathol Biol., 44, 25.

Zemskov, V., Khrapach, V., Liashenko, V. (1992). Value of exhaled air acetone level in assessing the impairement of secretory pancreatic function in acute destructive pancreatitis. Klin Khir., 11, 9–11.

Tangerman, A., Winkel, E. G., de Laat, L., van Oijen, A. H., de Boer, W. A. (2012). Halitosis and Helicobacter pylori infection. Journal of Breath Research, 6 (1), 017102. doi: 10.1088/1752-7155/6/1/017102

Bajerman, K. (1987). Opredelenie sledovyh kolichestv organicheskih veshhestv. Moscow: Mir, 429.

Španěl, P., Smith, D. (2007). Selected ion flow tube mass spectrometry for on-line trace gas analysis in biology and medicine. European Journal of Mass Spectrometry, 13 (1), 77–82. doi: 10.1255/ejms.843

Boshier, P. R., Cushnir, J. R., Mistry, V., Knaggs, A., Španěl, P., Smith, D., Hanna, G. B. (2011). On-line, real time monitoring of exhaled trace gases by SIFT-MS in the perioperative setting: a feasibility study. Analyst, 136 (16), 3233. doi: 10.1039/c1an15356k

Smith, D., Španěl, P. (2011). Direct, rapid quantitative analyses of BVOCs using SIFT-MS and PTR-MS obviating sample collection. TrAC Trends in Analytical Chemistry, 30 (7), 945–959. doi: 10.1016/j.trac.2011.05.001

Dummer, J. F., Storer, M. K., Hu, W.-P., Swanney, M. P., Milne, G. J., Frampton, C. M. et. al. (2010). Accurate, reproducible measurement of acetone concentration in breath using selected ion flow tube-mass spectrometry. Journal of Breath Research, 4 (4), 046001. doi: 10.1088/1752-7155/4/4/046001

Vaks, V., Domracheva, E., Maslennikova, A. (2012). Primenenie metodov i sredstv nestacionarnoj spektroskopii subTGc i TGc diapazonov chastot dlja neinvazivnoj medicinskoj diagnostiki. Opticheskij Zhurnal, 79 (2), 9.

Vaks, V., Domracheva, E., Sobakinskaya, E., Chernyaeva, M. (2012). Upgrading the sensitivity of spectroscopy gas analysis with application of supersonic molecular beams. Journal of Applied Physics, 111 (7), 074903. doi: 10.1063/1.3699053

Vaks, V., Balakirev, V., Panin, A. (2010). Razrabotka fizicheskih principov postroenija i realizacii spektrometra diapazona 500-700GHz so sverhprovodnikovym integral'nym priemnikom. Fizika Tverdogo Tela, 52 (11), 2100–2103.

Kucheruk, V. (1999). Analiz isnujuchyh zasobiv vymirjuvannja mehanichnyh harakterystyk elektrychnyh mashyn. Vymirjuval'na Tehnika Ta Metrologija, 54, 125–138.

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Published

2015-12-22

Issue

Vol. 12 No. 1 (17) (2015)

Section

Biological sciences

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Copyright (c) 2015 Артур Олександрович Запорожець, Анастасія Дмитрівна Свердлова

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