Фактор росту фібробластів-21 в крові у хворих неалкогольною жировою хворобою печінки на тлі гіпертонічної хвороби
DOI :
https://doi.org/10.15587/2313-8416.2016.67683Mots-clés :
фактор росту фібробластів-21, неалкогольна жирова хвороба печінки, гіпертонічна хвороба, надлишкова вага тіла, ожирінняRésumé
Встановлено, що жирова тканина виробляє значну кількість регулюючих білків, так званих адипокінів, які діють як локальні ендокринні залози та надають місцеві, периферичні і центральні ефекти. Викладено основні результати вивчення рівнів фактору росту фібробластів-21 в плазмі крові у хворих на неалкогольну жирову хворобу печінки на тлі гіпертонічної хвороби із надлишковою вагою тіла та ожирінням І ступеню та їх асоціація із станом вуглеводного, ліпідного обміну, ферментативної активності печінки
Références
Welsh, J. A., Karpen, S., Vos, M. B. (2013). Increasing Prevalence of Nonalcoholic Fatty Liver Disease Among United States Adolescents, 1988–1994 to 2007–2010. The Journal of Pediatrics, 162 (3), 496–500.e1. doi: 10.1016/j.jpeds.2012.08.043
Bekaert, M., Verhelst, X., Geerts, A., Lapauw, B., Calders, P. (2015). Association of recently described adipokines with liver histology in biopsy-proven non-alcoholic fatty liver disease: a systematic review. Obesity Reviews, 17 (1), 68–80. doi: 10.1111/obr.12333
Bojarynova, M. A., Rotar', O. P., Konrady, A. O. (2014). Adypokynу y kardyometabolycheskyj syndrom. Arteryal'naja gypertenzyja, 20 (5), 422–432.
Reshetilov, Ju. I., Bogoslav, T. V., Kuznjecova, L. P. (2014). Osoblyvosti likuval'nogo harchuvannja hvoryh na arterial'nu gipertenziju. Gastroenterologija, 3, 84–88.
Chen, S.-J., Yen, C.-H., Huang, Y.-C., Lee, B.-J., Hsia, S., Lin, P.-T. (2012). Relationships between Inflammation, Adiponectin, and Oxidative Stress in Metabolic Syndrome. PLoS ONE, 7 (9), e45693. doi: 10.1371/journal.pone.0045693
Drapkyna, O. M., Popova, Y. R. (2013). Rol' ozhyrenyja v razvytyy arteryal'noj gypertenzyy y nealkogol'noj zhyrovoj bolezny pecheny. Ukrai'ns'kyj medychnyj chasopys, 2, 125–128.
Farrell, G. C., Wong, V. W.-S., Chitturi, S. (2013). NAFLD in Asia – as common and important as in the West. Nat Rev Gastroenterol Hepatol, 10 (5), 307–318. doi: 10.1038/nrgastro.2013.34
Musso, G., Cassader, M., Rosina, F., Gambino, R. (2012). Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials. Diabetologia, 55 (4), 885–904. doi: 10.1007/s00125-011-2446-4
Fracanzani, A. L., Valenti, L., Bugianesi, E., Andreoletti, M., Colli, A., Vanni, E. et. al (2008). Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: A role for insulin resistance and diabetes. Hepatology, 48 (3), 792–798. doi: 10.1002/hep.22429
Iglesias, P., Selgas, R., Romero, S., Diez, J. J. (2012). MECHANISMS IN ENDOCRINOLOGY: Biological role, clinical significance, and therapeutic possibilities of the recently discovered metabolic hormone fibroblastic growth factor 21. European Journal of Endocrinology, 167 (3), 301–309. doi: 10.1530/eje-12-0357
Semba, R. D., Sun, K., Egan, J. M., Crasto, C., Carlson, O. D., Ferrucci, L. (2012). Relationship of Serum Fibroblast Growth Factor 21 with Abnormal Glucose Metabolism and Insulin Resistance: The Baltimore Longitudinal Study of Aging. The Journal of Clinical Endocrinology & Metabolism, 97 (4), 1375–1382. doi: 10.1210/jc.2011-2823
Yang, S. J., Hong, H. C., Choi, H. Y., Yoo, H. J., Cho, G. J., Hwang, T. G. et. al (2011). Effects of a three-month combined exercise programme on fibroblast growth factor 21 and fetuin-A levels and arterial stiffness in obese women. Clinical Endocrinology, 75 (4), 464–469. doi: 10.1111/j.1365-2265.2011.04078.x
Woo, Y. C., Xu, A., Wang, Y., Lam, K. S. L. (2013). Fibroblast Growth Factor 21 as an emerging metabolic regulator: clinical perspectives. Clinical Endocrinology, 78 (4), 489–496. doi: 10.1111/cen.12095
Wan, X., Lu, X., Xiao, Y., Lin, Y., Zhu, H., Ding, T. et. al (2014). ATF4- and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress. BioMed Research International, 2014, 1–9. doi: 10.1155/2014/807874
Yan, H., Xia, M., Chang, X., Xu, Q., Bian, H., Zeng, M. et. al (2011). Circulating Fibroblast Growth Factor 21 Levels Are Closely Associated with Hepatic Fat Content: A Cross-Sectional Study. PLoS ONE, 6 (9), e24895. doi: 10.1371/journal.pone.0024895
Yilmaz, Y., Eren, F., Yonal, O., Kurt, R., Aktas, B., Celikel, C. A. et. al (2010). Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease. European Journal of Clinical Investigation, 40 (10), 887–892. doi: 10.1111/j.1365-2362.2010.02338.x
Dushay, J., Chui, P. C., Gopalakrishnan, G. S., Varela–Rey, M., Crawley, M., Fisher, F. M. et. al (2010). Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease. Gastroenterology, 139 (2), 456–463. doi: 10.1053/j.gastro.2010.04.054
Li, H., Fang, Q., Gao, F., Fan, J., Zhou, J., Wang, X. et. al (2010). Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. Journal of Hepatology, 53 (5), 934–940. doi: 10.1016/j.jhep.2010.05.018
Stein, S., Stepan, H., Kratzsch, J., Verlohren, M., Verlohren, H.-J., Drynda, K. et. al (2010). Serum fibroblast growth factor 21 levels in gestational diabetes mellitus in relation to insulin resistance and dyslipidemia. Metabolism, 59 (1), 33–37. doi: 10.1016/j.metabol.2009.07.003
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