https://journals.uran.ua/sr_med <p style="font-weight: 400;"><em>"ScienceRise: Medical Science" </em>is a peer-reviewed scientific journal published 4 times a year.</p> <p style="font-weight: 400;">ScienceRise: Medical Science primarily publishes original research and clinical cases, but also accepts high-quality literature reviews and meta-analyses for publication. Short notices, short reviews, reports and messages are not published in the journal.</p> <p style="font-weight: 400;">The subject matter of the journal covers the areas of research devoted to treatment technologies, in particular, under conditions when the possibilities of decision-making regarding the treatment strategy are limited by insufficient sampling of diagnostic data, conditions for conducting long-term studies of chronic processes, the absence of conditions that would allow obtaining a sufficient volume of data sampling to determine adequate and effective treatment strategy. Related diagnostic problems are also considered.</p> <p style="font-weight: 400;">The journal is accredited by the Ministry of Health of Ukraine in the field of medical sciences and is recommended for publishing the results of dissertation research. <a href="http://nfv.ukrintei.ua/view/5b1925e37847426a2d0ab7e7">Included in the "B" category of the "List of Professional Publications of Ukraine"</a> (order of the Ministry of Education and Culture of Ukraine No. 612 of 07.05.2019).</p> <p>Registration of an entity in the media sector: Decision of the National Council of Ukraine on Television and Radio Broadcasting No. 695 dated August 10, 2023, protocol No. 17 (media identifier R30-01132).</p> <p style="font-weight: 400;">The journal is international, accredited by CrossRef and COPE and indexed by world resources of scientific periodicals.</p> <p><a href="https://portal.issn.org/resource/ISSN/2519-478X">ISSN 2519-478X</a>, <a href="https://portal.issn.org/resource/ISSN/2519-4798ISSN">E-ISSN 2519-4798</a>, <a href="https://portal.issn.org/resource/ISSN/2519-478X">ISSN-L 2519-478X</a><br /><br />Drawing up the items of the publication ethics policy of the journal «ScienceRise: Medical Science» Editors followed the recommendations of Committee on Publication Ethics <a href="http://publicationethics.org/">(COPE)</a>.</p> ТЕСHNOLOGY СЕNTЕR PC en-US ScienceRise: Medical Science 2519-478X <p>Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.</p> <p>Authors, who are published in this journal, agree to the following conditions:</p> <p>1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.</p> <p> 2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.</p> https://journals.uran.ua/sr_med/article/view/343791 <p>The <strong>aim</strong> of the study was to carry out a comparative effect assessment of methotrexate (MTX), adalimumab (ADA), and tocilizumab (TOC) on the blood lipid profile in children with JIA to figure out possible metabolic consequences and risks.</p> <p><strong>Materials and methods: </strong>120 patients with JIA were enrolled in the study and later divided into 3 different therapy-based groups: ADA group (n=60), TOC group (n=30), and MTX group (n=30). All patients underwent the same clinical, laboratory and instrumental evaluation, which included the disease activity assessment by JADAS27 scale and lipid profile analysis (total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), very low density lipoprotein cholesterol (VLDL-C), triglycerides (TG), atherogenic coefficient (AC), both at disease onset and 3 months after reaching the pharmacological remission.</p> <p><strong>Results</strong>: There were no statistically significant differences in TC, VLDL-C, and AC levels between the therapy groups at enrollment. However, the TOC group had higher TG and VLDL-C levels. All groups showed decreases in LDL-C and HDL-C levels, therefore suggesting a “lipid paradox”. Statistically significant differences were detected during remission: patients in the ADA group had a stable lipid profile with increasing HDL-C levels, whereas in the TOC and MTX groups a significant increase in atherogenic lipid parameters was seen (TC, LDL-C, TG, AC) together with a reduction in HDL-C levels. The relative incidence of dyslipidemia in remission was 33% in the ADA group, 97% in the TOC group, and 73% in the MTX group. Only in ADA group, 8.3% of patients showed regression of dyslipidemia. Spearman correlation analysis showed direct relations of JIA activity by JADAS27 with atherogenic lipids, confirming the inflammation influence on lipid metabolism even in remission.</p> <p><strong>Conclusions:</strong> The results suggest that the use of different JIA therapy can significantly affect the blood lipid profile. TNF-α inhibitors helped to stabilize or even improve lipid profiles, while the therapy with tocilizumab and methotrexate was associated with the development of atherogenic dyslipidemia. This confirms the need for lipid profile monitoring in children with JIA</p> Olena Onufreiv Yeva-Emiliia Kulchytska Copyright (c) 2025 Olena Onufreiv, Yeva-Emiliia Kulchytska http://creativecommons.org/licenses/by/4.0 2025-11-30 2025-11-30 3 (64) 4 13 10.15587/2519-4798.2025.343791 https://journals.uran.ua/sr_med/article/view/344663 <p><strong>Aim:</strong> to establish the features of the configuration of generalized periodontal diseases and their clinical manifestations in the format of basic characteristics of type 2 diabetes mellitus.</p> <p><strong>Materials and methods:</strong> Clinical, radiological and statistical methods were used. The subjects were 75 patients with type 2 diabetes mellitus, aged 19-44 years (mean age 26±3.8), who made up the main group (M), and 60 patients without signs of diabetes mellitus of a similar age - the comparison group (C). For a detailed analysis of the features of the clinical manifestation of GPD in patients with diabetes mellitus, all patients of the main (M) and comparison (C) groups were divided into several subgroups. M1 subgroup - patients with various forms of gingivitis. M2 subgroup was represented by patients with generalized periodontitis (GP) with type 2 diabetes mellitus as the underlying pathology. The comparative (C) group included two subgroups (C1), (C2) with different forms of gingivitis and periodontal disease, respectively.</p> <p><strong>Results of our own studies.</strong> A high frequency of periodontal disease was diagnosed, reaching 100%, including both independent diseases of the periodontal soft tissues and all components of the periodontal complex, which was characteristic of all age groups and depended on the age of the patients, the duration and stages of type 2 diabetes. Periodontitis was mainly of stages I-II, chronic course prevailed over other stages of periodontal disease (80±4.6%). Radiologically, all patients, regardless of the severity of periodontal disease, had a characteristic vertical and horizontal type of resorption, pronounced osteoporosis of the bone component of the periodontal complex and expansion of the periodontal gap. The advantages and priorities of different segments of periodontal complex damage were traced in no case. For all patients with GP, a high degree of tissue sensitization to bone antigen was finalized, characterizing significant changes in the bone component of the periodontal complex in type 2 diabetes. A hypothesis of a plausible paradigm of the interdependence of GPD and type 2 diabetes as affiliated diseases was proposed as the first stage of further development of this direction.</p> <p><strong>Conclusions:</strong> a direct relationship and interdependence of generalized periodontal diseases in the format of basic characteristics of type 2 diabetes have been established</p> Anna Lenihevych Ljudmila Reshetnyk Copyright (c) 2025 Anna Lenihevych, Ljudmila Reshetnyk http://creativecommons.org/licenses/by/4.0 2025-11-30 2025-11-30 3 (64) 14 20 10.15587/2519-4798.2025.344663