ScienceRise: Pharmaceutical Science <p><em>«ScienceRise: Pharmaceutical Science» </em><em>–</em> scientific peer-reviewed journal, published 6 times a year, included in category «A» «List of scientific professional editions of Ukraine» (Сertificated by order of Ministry of Education and Science of Ukraine No. 420 from 19.04.2021).</p> <p><em>The main mission of the journal </em>– dissemination of the results of scientific research aimed at ensuring the quality of pharmaceutical assistance to the population through targeted search and modern pharmaceutical development of innovative medicines, the creation of modern quality management systems at pharmaceutical enterprises in the industry.</p> <p>In the journal<em> «ScienceRise: Pharmaceutical Science» </em>publishes research designed and implemented taking into account the Quality by design concept with widespread use of computational methods.</p> <p>The journal is intended for scientists, pharmacists, doctors, educators, and healthcare professionals.</p> <p><em>Innovations in pharmaceutical science - </em>for practical use.</p> <p><a href="">ISSN 2519-4844 </a> (print), <a href="">ISSN 2519-4852 </a>(on-line) <br /><br />Drawing up the items of the publication ethics policy of the journal «ScienceRise: Pharmaceutical Science» Editors followed the recommendations of Committee on Publication Ethics <a href="">(COPE)</a>.</p> ТЕСHNOLOGY СЕNTЕR PC en-US ScienceRise: Pharmaceutical Science 2519-4844 <p>Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.</p> Acute heat trauma model in rats, gender-dependent thermoresistance, and screening of potential thermoprotectors <p>Heat trauma (HT) is an urgent medical and social problem. Heat damage is a widespread effect of the environment on humans, driven by global warming, military conflicts, technological disasters, work in hot environments, and engagement in extreme sports and tourism.</p> <p><strong>The aim</strong> of the study: to propose a model of acute HT in rats that does not cause the death of animals, to determine the dependence of thermoresistance on gender, and to compare the effectiveness of the thermoprotective effects of a range of non-steroidal anti-inflammatory drugs (NSAIDs), paracetamol, and glucosamine hydrochloride in this model.</p> <p><strong>Materials and Methods:</strong> The experiment was conducted on adult white rats of both genders. Acute HT was modelled by using a specially developed method involving heat exposure to animals at +55 °C for 30 minutes, followed by a recovery period of 60 minutes. Rectal temperature was measured every 15 minutes. The degree of hyperthermia in males and females was determined. The presence and intensity of the thermoprotective effect of glucosamine hydrochloride (G h/ch), diclofenac sodium, acetylsalicylic acid (ASA), nimesulide, etoricoxib, celecoxib, and paracetamol were evaluated through intragastric administration 60 minutes before heat exposure. The results were analyzed using the STATISTICA 12.0 program.</p> <p><strong>Results:</strong> It was established that heat exposure at +55 °C for 30 minutes effectively replicates acute HT in rats without causing animal fatalities, adhering to bioethical requirements. Body temperature increases by 10-13 %, characterized as a heat stroke. Occasionally, thermoresistant animals are encountered, where the temperature increase during the first 15 minutes of exposure is less than 1 °C. These animals should not be used for further modelling of heat trauma. Male rats are more sensitive to the effect of high environmental temperatures than females, exhibiting greater hyperthermia (temperature increase of 5.03±0.39°C compared to 3.72±0.22 °C in females, p&lt;0.01). The thermoprotective effect of glucosamine hydrochloride depends on gender, being more pronounced in males. Among the 6 tested COX inhibitors, the most significant thermoprotective effect was observed in the highly selective COX-2 inhibitor celecoxib and the weakly selective central inhibitor paracetamol, warranting in-depth research into their impact on organ and system states following heat trauma, as well as the mechanisms of their thermoprotective action. The thermoprotective effect is not associated with selectivity towards COX (cyclooxygenase): it is not observed in the highly selective COX-2 inhibitor etoricoxib and moderately selective COX-2 inhibitor nimesulide, as well as in non-selective COX inhibitors such as diclofenac sodium and aspirin, which also slows down the recovery of body temperature after heat exposure.</p> <p><strong>Conclusions:</strong> A convenient and simple model of acute HT in rats is proposed, demonstrating higher thermosensitivity and a more pronounced thermoprotective effect of glucosamine hydrochloride in males. A significant thermoprotective effect was identified in celecoxib and paracetamol, surpassing other investigated NSAIDs. The mechanism and specific features of this effect require further clarification</p> Polina Chuykova Sergii Shtrygol’ Andrii Taran Tetiana Yudkevych Iryna Lebedinets Denys Oklei Copyright (c) 2024 Polina Chuykova, Sergii Shtrygol’, Andrii Taran, Tetiana Yudkevych, Iryna Lebedinets, Denys Oklei 2024-04-30 2024-04-30 2 (48) 4 11 10.15587/2519-4852.2024.301620 Study of the degradation behavior of enisamium iodide, tilorone dihydrochloride, morpholinium thiazotate in the soil by the GC-Fid method <p><strong>The aim.</strong> To study the behaviour of enisamium iodide, thiloron dihydrochloride, morpholinium thiazotate, and the suitability of the previously developed GC-FID methodology in soil.</p> <p><strong>Materials and methods.</strong> The determination of the Enisamium iodide, Tilorone dihydrochloride, and Morpholinium thiazotate in soil gas chromatography with a flame ionization detector using the Rxi-5 ms (30 m long, 0.25 mm outer diameter and 0.25 μm liquid stationary phase thickness).</p> <p><strong>Results.</strong> A study was conducted on the behaviour of enisamium iodide, thiloron dihydrochloride, and morpholinium thiazotate in soil, along with the assessment of the suitability of the developed GC-FID methodology for determination in soil. The half-life in soil was investigated, which amounted to 45 days for enisamium iodide, 30 days for thilorone dihydrochloride, and 7 days for morpholinium thiazotate, with corresponding decay rate constants of 0.001 mg/mL, 0.001 mg/mL, and 0.0005 mg/mL, respectively.</p> <p><strong>Conclusions. </strong>The previously developed GC-FID methodology is suitable for the determination of enisamium iodide, thilorone dihydrochloride, and morpholinium thiazotate in soil, with necessary analysis conditions established. Under aerobic conditions, the selected pharmaceutical preparations' dispersion rate followed the following decreasing order: enisamium iodide &gt; thilorone dihydrochloride &gt; morpholinium thiazotate in soil</p> Anastasiia Belikova Liudas Ivanauskas Lyudmila Sidorenko Oleksandr Honcharov Olha Holovchenko Zoia Kovalenko Victoriya Georgiyants Copyright (c) 2024 Anastasiia Belikova, Liudas Ivanauskas, Lyudmila Sidorenko, Oleksandr Honcharov, Olha Holovchenko, Zoia Kovalenko, Victoriya Georgiyants 2024-04-30 2024-04-30 2 (48) 12 18 10.15587/2519-4852.2024.300209 Variation in the composition of the essential oil of commercial Artemisia absinthium L. herb samples from different countries <p>Wormwood (Artemisia absinthium L., Asteraceae) is an aromatic bitter herb that contains bitter-tasting metabolites and essential oil. The composition and biological effects of A. absinthium essential oil have been widely studied. However, the data on the content of the individual components vary significantly.</p> <p><strong>The aim.</strong> The aim of the study was to research the compositions of essential oils from A. absinthium herb, which are on the market in various European countries and determine difference in their compositions, possible chemotypes, and compliance of the essential oil samples with the European Pharmacopeia requirements.</p> <p><strong>Materials and Methods.</strong> The composition of 16 essential oil samples of A. absinthium herb from different countries was investigated using the gas chromatography method. Samples were obtained from retail pharmacies in 14 different countries.</p> <p><strong>Research results.</strong> A total of 41 compounds were identified in the studied A. absinthium essential oils. In all the samples, monoterpenes and monoterpenoids dominate (28.0-92.2 %), much less sesquiterpenes and sesquiterpenoids (0-18.9 %). The dominant components among the identified ones were sabinene (traces(tr.)-21,2 %), myrcene (0.1-25.6 %), p-cymene (0.2-6.5 %), 1,8-cineole (0.1-18.0 %), artemisia ketone (tr.-14.9 %), linalool (tr.-10.8 %), β-thujone (0.1-38.7 %), (E)-epoxyocymene (tr.-59.7 %), (E)-verbenol (tr.-7.9 %), borneol (tr.-11.7 %), (E)-sabinyl acetate (tr.-70.5 %), neryl butyrate (0-13.9 %), spathulenol (tr.-9.2 %), caryophyllene oxide (tr.-7.3 %). Both “pure”-chemotypes and “mixed”-chemotypes of A. absinthium have been defined.</p> <p><strong>Conclusions. </strong>Two”pure”-chemotype consist of 70.5 % (E)-sabinyl acetate and 59,2 % (E)-epoxyocymene, respectively. Also, eleven "mixed"-chemotypes of A. absinthium essential oils have been defined. Some correlations were established between the content of terpenes in the A. absinthium essential oils</p> Raal Ain Тetiana Ilina Alla Kovaleva Anne Orav Margit Karileet Mariana Džaniašvili Taras Koliadzhyn Andriy Grytsyk Oleh Koshovyi Copyright (c) 2024 Raal Ain, Тetiana Ilina, Alla Kovaleva, Anne Orav, Margit Karileet, Mariana Džaniašvili, Taras Koliadzhyn, Andriy Grytsyk, Oleh Koshovyi 2024-04-30 2024-04-30 2 (48) 19 28 10.15587/2519-4852.2024.302232 Sociological research of the men’s androgenic alopecia problem <p>Diseases of the skin and its appendages currently occupy one of the leading places in terms of prevalence. In addition, today the relationship between dermatopathologies and the psychoemotional state of people and vice versa is clearly monitored. Psychodermatology is engaged in the study of exactly this regularity. One of the most common trichological diseases is androgenic alopecia, which is characterized by excessive hair loss under the influence of androgens in individuals with a hereditary predisposition. Androgenic alopecia is often accompanied by secondary mental disorders, which significantly impair the quality of people’s life. It is relevant to conduct sociological research of this problem among men of all age groups. Such research will reveal the level of influence of androgenic alopecia on the psychoemotional state of men who may be potential consumers of medicines and dermatocosmetics.</p> <p><strong>The </strong><strong>aim</strong><strong> of the work </strong>was to conduct a sociological study to establish the impact of androgenic alopecia on the psychoemotional state of men and their readiness for pharmacotherapy.</p> <p><strong>Materials and methods.</strong> Sociological research was conducted from 01.03.2019 to 31.08.2019 by surveying 150 men aged 18 to 66. Respondents were visitors to pharmacies in the Ivano-Frankivsk and Chernivtsi regions of Ukraine, who gave written consent to participate in the survey. Only persons with visible manifestations of androgenic alopecia according to the Norwood scale were included in the survey. All respondents were divided into the following age groups: from 18 to 20 years old, from 21 to 30 years old, from 31 to 40 years old, from 41 to 50 years old, from 51 to 60 years old, from 61 years old and older. The distribution was carried out to segment the target market. The results of the study were displayed as percentages with 95 % confidence intervals. Statistical analysis was performed using R version 4.1.2 (R Core Team (2021).</p> <p><strong>The results. </strong>According to the results of the sociological study, 48.7 % of interviewed men consider that androgenic alopecia is a problem which can affect the emotional state and, so, the quality of life. As a result, about 90 % of the respondents indicated that they need to expand the assortment of effective remedies to solve this problem on the pharmaceutical market of Ukraine, of which 36.7 % are ready to pay for a course of effective pharmacotherapy from 200 to 500 hryvnias.</p> <p><strong>Conclusions. </strong>The obtained results confirm that androgenic alopecia has a negative effect on the psychoemotional state of men and worsens their quality of life. To solve the problem of androgenic alopecia, men are interested in using effective medicinal or dermatocosmetic products</p> Mariana Fedorovska Inna Yarema Anna Sinichenko Olena Hlushchenko Oksana Strus Copyright (c) 2024 Mariana Fedorovska, Inna Yarema, Anna Sinichenko, Olena Hlushchenko, Oksana Strus 2024-04-30 2024-04-30 2 (48) 29 35 10.15587/2519-4852.2024.302322 Research for the selection of taste corrigents, filter materials and primary packaging for oral solution with magnesium salts <p><strong>The aim.</strong> Theoretically and experimentally, justify the choice of excipients for a combined oral solution with organic magnesium salts. Determine the compatibility of filter materials of three types. Select single-dose primary packaging for the developed oral solution and confirm its suitability during the relevant studies.</p> <p><strong>Materials and methods. </strong>Organoleptic, physicochemical, and pharmaco-technological methods were used in the investigation. All methods meet the requirements of the State Pharmacopoeia of Ukraine and the European Pharmacopoeia. Organoleptic methods indicated the taste of the medicinal speciality behind the methods of O.I. Tentsova and I.A. Egorov. Physicochemical methods were used to determine pH, colour, density, and quantitative amount of active pharmaceutical ingredients. Pharmaco-technological methods were used to determine the properties of filter materials and primary packaging.</p> <p><strong>Results. </strong>A sweetener and a flavouring agent for an oral solution with magnesium salts were selected based on the research. Saccharin sodium was selected as a sweetener in the amount of 0.15 %. «Cherry» in the amount of 0.4 % and «caramel» in the amount of 0.2 % were selected as flavouring agents. As a result of experiments, the suitability of filter materials made of сapron, nylon and polyethersulfone was proven. This is determined by the constancy of the main quality indicators of the drug 24, 48 and 72 hours after filtration. The suitability of the single-dose primary packaging in the process of storing the oral solution has been studied and proven. In the work, polymer ampoules of the «Moplen EP 2S 12 B» brand and the «Purell HP 371P» brand were used. The conducted research allows us to create a competitive domestic drug that will be technologically simple and convenient in administration and will also be distinguished by relatively low raw material costs and production.</p> <p><strong>Conclusions. </strong>Based on theoretical and experimental studies, auxiliary substances, such as sweeteners and flavouring agents, were selected for the combined magnesium-containing drug. The suitability of filter materials for the combined oral solution was investigated and confirmed. The suitability of single-dose primary packaging of two types was selected and experimentally proven</p> Daria Snehyrova Lyudmila Almakaieva Copyright (c) 2024 Daria Snehyrova, Lyudmila Almakaieva 2024-04-30 2024-04-30 2 (48) 36 43 10.15587/2519-4852.2024.302066 Two masterful alternative spectrophotometric methods for the determination of ramipril in tablets <p><strong>The aim of the work was </strong>to develop two simple, rapid, economic, alternative spectrophotometric methods for the determination of ramipril in tablets based on the reaction with sulfonephthalein dyes (bromphenol blue (BPB) and cresol red (CR)).</p> <p><strong>Materials and methods.</strong> Analytical instrumentation: Shimadzu UV-1800 double beam UV-VIS spectrophotometer (Japan) with attached UV-Probe ver. 2.62 software, RAD WAG AS 200/C precise analytical balance (Poland). Ramipril (purity <a href="">≥98 % (HPLC)</a>) was purchased from AARTI Industries Limited (India). Ramipril tablets 5 mg and 10 mg were purchased from a local pharmacy.</p> <p><strong>Results and discussion.</strong> Two spectrophotometric methods for the determination of ramipril in tablets have been developed. We have tested various sulfophthalein dyes (BPB, bromocresol green, bromthymol blue, thymol blue, CR) in order to choose the optimal for the method development. According to the results of the experimental studies, we chose BPB and CR as reagents, and the solvent was acetonitrile for both methods. The optimal conditions for the quantitative determination of ramipril in tabletsy using BPB were established: dye concentration - 2.35×10<sup>-4 </sup>mol/L, volume of BPB solution – 1.0 ml, without heating, wavelength – 598 nm, reaction time – 5 min, temperature of the solution – 25 °C. The optimal conditions for the quantitative determination of ramipril in tabletsusing CR were established: dye 1.33×10<sup>-4 </sup>mol/L, volume of CR solution – 1.0 ml, without heating, wavelength – 395 nm, reaction time – 5 min, temperature of the solution – 25 °C. The spectrophotometric method by using BPB was linear in the concentration range of 1.99-5.96 µg/mL, LOD – 0.20 µg/mL, LOQ – 0.60 µg/mL. The spectrophotometric method using CR was linear in the concentration range of 0.42-5.44 µg/mL, LOD – 0.10 µg/mL, and LOQ – 0.36 µg/mL. The results of the study on robustness, accuracy, and precision were within the acceptance criteria. The results of studying the «greenness» of both methods indicate an excellent «green» analysis.<strong>Conclusions.</strong> Developed methods can be used as an alternative method for the routine analysis of ramipril tablets</p> Kateryna Typlynska Mariana Horyn Tetyana Kucher Liubomyr Kryskiw Liliya Logoyda Copyright (c) 2024 Kateryna Typlynska, Mariana Horyn, Tetyana Kucher, Liubomyr Kryskiw, Liliya Logoyda 2024-04-30 2024-04-30 2 (48) 44 52 10.15587/2519-4852.2024.302635 Formulation of mouth-dissolving tablets containing a spray-dried solid dispersion of poorly water-soluble fenoprofen calcium dihydrate and its characterization <p><strong>The aim </strong>and objective of this investigation focus on the formulation of mouth-dissolving tablets of Fenoprofen calcium dihydrate spray dried solid dispersions.</p> <p><strong>Materials and methods. </strong>Spray drying is a well-recognized manufacturing technique that can be used to create amorphous solid dispersions, which are an effective delivery method for poorly water-soluble pharmaceuticals such as Fenoprofen calcium dihydrate (FCD). In addition to skimmed milk powder (SMP) and FCD, the carrier β-cyclodextrin was used to produce solid dispersions.</p> <p><strong>Results and discussion. </strong>The production of solid dispersions yielded reproducible results. Solid dispersion with β-cyclodextrin and skimmed milk powder is one way to increase disintegration time by increasing the water solubility of inadequately water-soluble FCD. In-vitro dissolution experiments of FCD mouth-dissolving tablets revealed significant differences. Stability studies should evaluate drug product characteristics that are susceptible to change during storage and are anticipated to impact quality, safety, and efficacy to demonstrate that the optimal formulations remain stable over the course of the study. The results of stability experiments were statistically significant at p&lt;0.05 using one-way ANOVA followed by Dunnet's test. During in-vivo anti-inflammatory experiments, the formulation SDC6 demonstrated a greater percentage of inhibition than the purified drug and super disintegrant, and the results were statistically significant using one-way ANOVA followed by the Bonferroni test.</p> <p><strong>Conclusions. </strong>The solid dispersions were prepared with β-cyclodextrin, and skimmed milk powder improved the solubility of the poorly water-soluble fenoprofen calcium dihydrate. In vitro dissolution experiments of fenoprofen calcium dihydrate mouth dissolving tablets and controlled tablets revealed significant differences</p> Shailendra Singh Narwariya Suman Jain Alagusundaram Muthumanickam Copyright (c) 2024 Shailendra Singh Narwariya, Suman Jain, Alagusundaram Muthumanickam 2024-04-30 2024-04-30 2 (48) 53 61 10.15587/2519-4852.2024.302788 Development and validation of a method for simultaneous quantitative determination of albendazole and praziquantel in coated tablets “AP-helmin” <p>Adapting modern methods of quantitative analysis of active substances in their joint content in the dosage form and validating them is an integral process of pharmaceutical development. We have developed a drug in the form of coated tablets for the treatment of helminthiases of the digestive system in adults. A feature of this drug is the composition of the API of albendazole and praziquantel in a ratio of 1:4.</p> <p><strong>The aim</strong> of this research is to develop methodology for quantitative analysis of both substances by the method of liquid chromatography, determination of their possible mutual influence on the process, as well as validation of the proposed methods.</p> <p><strong>Materials and methods.</strong> To meet the research's set purpose, the following tasks were identified: choosing the most rational method for the quantitative determination of albendazole and praziquantel; confirming the absence of the mutual influence of APIs on the results obtained; and validating the selected methods of albendazole and praziquantel analysis.</p> <p>Object of the research conducted included coated tablets “AP-helmin”, series 1-5.2021; pharmacopoeial standard sample (PSS) of albendazole, and PSS praziquantel. Quantitative determination of albendazole and praziquantel was conducted according to SPU, method 2.2.29.</p> <p><strong>Results.</strong> The article describes the conditions and stages of the quantitative determination of albendazole and praziquantel and the main indicators of method validation.</p> <p><strong>Conclusions.</strong> It was proven that quantification with the liquid chromatography method of both substances is validated, and the substances do not affect each other's analysis in the coated tablets "AP-helmin" following the project of QCM for this drug. All calculated parameters meet the required validation criteria</p> Kateryna Semchenko Liliia Vyshnevska Volodymyr Iakovenko Tetyana Kovalova Mykhailo Marchenko Yelizaveta Zuikina Yana Marchenko Copyright (c) 2024 Kateryna Semchenko, Liliia Vyshnevska, Volodymyr Iakovenko, Tetyana Kovalova, Mykhailo Marchenko, Yelizaveta Zuikina, Yana Marchenko 2024-04-30 2024-04-30 2 (48) 62 73 10.15587/2519-4852.2024.290350 Development of an emulsion composition with fennel and caraway essential oils for use in the combined therapy of ulcerative colitis <p><strong>The aim</strong> of the study is to develop the composition of an emulsion containing essential oils of Fennel and Caraway seeds for use in the symptomatic complex therapy of ulcerative colitis with the aim of eliminating functional intestinal disorders.</p> <p><strong>Materials and methods. </strong>The objects of the study were samples of emulsions containing active pharmaceutical ingredients (essential oils of Fennel and Caraway), purified water, oils (refined sunflower oil, refined olive oil, refined sesame oil), emulsifiers (polyethylene glycol 40 hydrogenated castor oil, polysorbate 80, polyethylene glycol 100 stearate, acacia gum, guar gum, xanthan gum, soya lecithin), viscosity regulator - apple pectin and flavouring agents (food additives with cherry and tarragon flavour).</p> <p>Organoleptic properties, stability, rheological parameters, pH, particle size determination by microscopy, and a taste test were carried out with model emulsion samples. Research to establish the optimal technological parameters was carried out in parallel.</p> <p><strong>Results.</strong> The main parameters of the technological process have been established, which allow to obtain an emulsion with evenly distributed particles: 15 minutes at maximum speed. The concentration of emulsifiers at which the emulsions are stable was selected. It was found that the samples containing polyethylene glycol 100 stearate, gums, and soy lecithin have satisfactory organoleptic properties.</p> <p>The sample with soy lecithin emulsifier differs from the others in its ability to form microemulsions, but it has low viscosity. To improve the rheological properties, apple pectin was added to the emulsion.</p> <p>The taste test showed that among vegetable oils, refined sesame oil has a more neutral taste, and the flavouring additive "Tarkhun" balances the taste better.</p> <p>The release of active pharmaceutical ingredients (APIs) from the emulsion base was confirmed by thin-layer chromatography.</p> <p><strong>Conclusions.</strong> A microemulsion with essential oils based on refined sesame oil, soy lecithin, with the addition of viscosity and flavour correctors was developed. The obtained emulsion has satisfactory organoleptic properties and conforms to the requirements for emulsion quality indicators</p> Oleksandr Shmalko Tetiana Kovalova Liubov Bodnar Volodymyr Kovalov Volodymyr Yakovenko Liliia Vyshnevska Copyright (c) 2024 Oleksandr Shmalko, Tetiana Kovalova, Liubov Bodnar, Volodymyr Kovalov, Volodymyr Yakovenko, Liliia Vyshnevska 2024-04-30 2024-04-30 2 (48) 74 82 10.15587/2519-4852.2024.302941 Study of the chemical components of CO2 extracts from the fruits of Sorbus aucuparia L. <p>The article presents the results of the study of the chemical composition of Sorbus aucuparia L. СО<sub>2</sub> subcritical extract.</p> <p>For the first time in Kazakhstan, 20 grams of brown Sorbus aucuparia L. extract were collected using subcritical carbon dioxide extraction. The current study was directed mainly to the chemical compositions of subcritical Sorbus aucuparia L. СО<sub>2</sub> subcritical extract.</p> <p>The Sorbus aucuparia L. extract's chemical compositions were determined using gas chromatography/mass spectrophotometry (GC-MS). The extract included the following main compounds: <strong>5-Methyl-2(3H)-furanone</strong> (30.18 %), 5-(3-Ethoxy-4,5-dihydro-isoxazol-5-yl)-5-methyl-imidazolidine-2,4-dione (3.20 %), 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl (2.53 %). Determined fatty acid profile and the moisture content of raw vegetable ingredients of Sorbus substance.</p> <p>Quantitative determination of fatty acids of ethanol extract was carried out. The results of the analysis for fatty acids in the study showed that linoleic (37.7 %) and oleic (50.5 %) were the most prominent fatty acids.</p> <p><strong>The aim</strong> of this study is to determine the component composition by using the GC-MS method and fatty acid to study the Sorbus aucuparia L. extract obtained by CO<sub>2</sub> extraction, which grows in Kazakhstan.</p> <p><strong>Materials and methods.</strong> To determine the possibility of using Sorbus aucuparia L., we carried out the composition and fatty acid of the extract obtained by CO<sub>2</sub> extraction in subcritical conditions of Sorbus aucuparia L. by a certain GC-MS method.</p> <p><strong>Results.</strong> The raw materials of the plant were collected in accordance with GACP requirements. Conducted subcritical CO<sub>2</sub> extraction of plant raw materials showed a 20 g extraction yield. Chemical compounds were discovered, bioactive components were identified, such as <strong>5-Methyl-2(3H)-furanone</strong> (30.18 %), 5-(3-Ethoxy-4,5-dihydro-isoxazol-5-yl)-5-methyl-imidazolidine-2,4-dione (3.20 %), 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl (2.53 %).</p> <p><strong>Conclusions.</strong> The possibility of using the obtained CO<sub>2</sub> extract of Sorbus aucuparia L. in the field of pharmaceutical products as a substance and a drug</p> Serzhan Mombekov Ubaidilla Datkhayev Dosmagulova Kalamkul Assel Kozhamzharova Ainash Baidullayeva Mukhamejan Assel Aigerim Kantureyeva Zura Yessimsiitova Damira Yussayeva Zaure Beken Akmaral Kydyrkhanova Aidana Karbozova Iryna Zhuravel Copyright (c) 2024 Serzhan Mombekov, Ubaidilla Datkhayev, Dosmagulova Kalamkul, Assel Kozhamzharova, Ainash Baidullayeva, Mukhamejan Assel, Aigerim Kantureyeva, Zura Yessimsiitova, Damira Yussayeva, Zaure Beken, Akmaral Kydyrkhanova, Aidana Karbozova, Iryna Zhuravel 2024-04-30 2024-04-30 2 (48) 83 89 10.15587/2519-4852.2024.303000 Directions of improving management of innovative activities in pharmaceutical companies <p><strong>The purpose of the work</strong> is to substantiate theoretical provisions and practical recommendations for improving the management of innovative activities of pharmaceutical companies (PC) for the implementation of strategic tasks regarding innovative development and increasing competitiveness.</p> <p><strong>Materials and methods</strong>. To achieve the goal of the study, scientific sources on innovation management and intellectual property management and the peculiarities of the organization of innovation processes in pharmacy were analyzed. When conducting research, methods of information search, systematization, comparison, and generalization were used, as well as the method of expert evaluations, taxonomic analysis, and a graphic method to increase the clarity of the presentation of the material.</p> <p><strong>The results</strong>. The main directions and features of innovative activity in pharmacy have been studied. A generalized algorithm for managing innovative activities in pharmaceutical companies is given. The relevance of evaluating and managing the innovative potential of PC to achieve a synergistic effect from the use of resources involved in innovative activities is substantiated. A structural model of the innovative potential of PC is proposed, which considers the peculiarities of the flow of innovative processes in pharmacy, related to the development and introduction of new pharmaceuticals to the market. A methodical toolkit for quantitative and qualitative evaluation of the innovative potential of PC has been defined. To improve the management of the PC's innovative activity, a methodology for determining the range of management decisions is proposed based on the results obtained in the framework of creating a report on the patent landscape.</p> <p><strong>Conclusions.</strong> In order to achieve the provision of effective and safe domestic drugs to the population of Ukraine, it is necessary to intensify research in the direction of the formation of an effective system of management of the innovative activity of pharmaceutical companies (PC), focused on their gradual transition to an innovative development model. The conducted analysis showed that despite a sufficiently large number of publications devoted to the problems of innovation management, issues related to the problem of forming an effective system of managing the innovative activity of PCs, as well as choosing an effective toolkit for evaluating and managing their innovative potential, taking into account the specifics of the flow of innovative processes in pharmacy, remain insufficiently disclosed and require further research. The proposed structural model of the innovative potential of the FC, a justified methodological toolkit for its assessment, as well as the construction of a cognitive map to determine the most appropriate key components and directions for further improvement and development of the innovative potential will contribute to increasing the efficiency of the innovative activities of enterprises and the implementation of the goals of the innovation strategy. The developed algorithm of preventive management of innovative activity of the PC, aimed at improving the quality of decisions made on innovation management thanks to the use of patent landscape tools, will also contribute to the faster entry into the market of domestically produced innovative medicinal products</p> Sanjay Kumar Nayak Olga Posilkina Olena Litvinova Copyright (c) 2024 Olga Posilkina, Sanjay Kumar Nayak, Olena Litvinova 2024-04-30 2024-04-30 2 (48) 90 102 10.15587/2519-4852.2024.303060