Primary toxicological evaluation of nitroxoline on laboratory animals.

G. I. Yaskiv

Abstract


Nitroxoline is an effective antibacterial agent that is industrially produced by chemical and pharmaceutical enterprises in Ukraine. Parameters of its toxicity are determined under conditions of acute and subchronic toxicological experiments on 3 kinds of laboratory animals, by administering the drug orally and by application onto the skin and mucous membranes. The duration of acute experiment was 14 days, subchronical - 24 days. It was found that median lethal dose (DL50) for white female rats is 980 (852:1127) mg/kg, of white male rats – 835 mg/kg, white male mice– 660 mg/kg, by this parameter the drug can be attributed to 3 class of hazard – moderately hazardous substance. Average effective time of death (ET50) for albino rats is 28 hours. Species sensitivity of laboratory animals to nitroxoline is slightly expressed. The death of the animals starts on the first day after the injection and is recorded during three days of the experiment. In application on intact skin, locally-irritant and skin-resorptive effects are absent. After contact with the mucous membrane of the eye the drug causes weak irritant effect. Nitroxoline has a moderate cumulative activity.

Keywords


Nitroxoline; parameters of toxicity; skin-resorptive effect; locally irritating effect; cumulative activity

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References


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GOST Style Citations


  1. Методические указания к постановке исследо­ваний для обоснования санитарных стандартов вред­ных веществ в воздухе рабочей зоны: метод. указания № 2163-80. – Москва, 1980. – 20 с.
  2. Обґрунтування гранично допустимих кон­цен­трацій лікарських засобів у повітрі робочої зони і в атмосферному повітрі населених місць: метод. вка­зівки № 544, затверджені наказом МОЗ України від 21.10.2005 р. – Київ, 2015. – 19 с.
  3. Оценка воздействия вредных химических сое­динений на кожные покровы и обоснование пре­дельно допустимых уровней загрязнения кожи: МУ 2102-79. – Москва, 1980. – 23 с.
  4. A method for the evaluation of cumulation and to­le­ran­ce by the determination of acute and subchronic median ef­fective doses / R.K. Lim, K.G. Rink, H.G. Glass, E.A. Soa­je-Echague // Arch. Inter. Pharm.-1961.- Vol. 130.- P.336-352.
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