Risk factors and features of recurrent bacterial complications of upper respiratory tract viral infections in children.

A. V. Karpenko

Abstract


. The aim of the study was to determine risk factors for recurrent bacterial complications of the upper respiratory tract viral infection (URTI) in children, as well as the clinical and immunological features of the course of such complications. We enrolled 214 children aged 3-18 years with URTIs complicated with acute otitis media or acute bacterial rhinosinusitis. Frequency of bacterial complications of URI in 128 children was low (group I) and in 86 children it met the criteria of recurrent course (group II). In addition to the standard examination, lysozyme levels in the oropharyngeal secretion were determined three times during the disease. It was found that children of group II were characterized by an early debut of respiratory morbidity (at the age of 6.00 (4.00, 12.00) months against 13.00 (4.50, 16.00) months in children of group I (p<0,0001), as well as a longer duration of catarrhal and intoxication syndromes in similar forms of the disease. The most significant risk factors for the formation of the recurring complication pattern were maternal smoking (OR=2.73, 95% CI [1.34, 5.48]), along with gastroenterological pathology and frequent URTI in the mother and a shortened period of breastfeeding. In children with recurrent bacterial complications of URTI, there was an impaired local resistance of the upper respiratory tract mucous membranes (as a decrease in the concentrations of lysozyme) in all periods of the disease, which persisted after recovery.


Keywords


acute otitis media; acute rhinosinusitis; URTI; lysozyme; children

Full Text:

PDF

References


Krivopustov CP. [Acute otitis media in children: the pediatrician’s attitude]. Dityachiy lіkar. 2010;1:12-18. Russian.

Kryuchko TA, Shpekht TV, Tkachenko OYa. [Acute otitis media in children: contemporary views on the issue]. Zdorov'e rebenka. 2010;2(23):7-10. Russian.

Nesterova IV. [Problems of treatment of viral and bacterial infections in immune coppromised children with frequent respiratory infections]. Lechashchiy vrach. 2009;6:40-43. Russian.

Rebrova OY. [Statistical analysis of medical data. Application of STATISTICA software]. Moskva: Media Sfera; 2006. Russian.

PleshIA, Kshanovskaya GI, Khomko OI, et al. [Mo­dern possibilities of clinical laboratory diagnostics]. Bu­ko­vinskiy meditsinskiy vestnik. 2014;1(69):147-50. Ukrainian.

Shcheplyagina LA.[Age-dependent features of the immune system in children]. RMZh. 2009;23:1564. Russian.

Fokkens WJ, Lund VJ, Mullol J. European posi­tion paper on rhinosinusitis and nasal polyps. Rhinology. 2007;45(Suppl 20):84-85.

Lopez Campos X, Alvarez Castello M, Massip J. Risk factors for recurrent upper respiratory infections in preschool children. World Allergy Organ J. 2012;5(Suppl 2):S101. doi: 10.1097/01.WOX.0000412013.14727.54

Schroder JM, Harder J. Antimicrobial skin pep­tides and proteins. Cellular and Molecular Life Sciences. 2006;63:469-486. doi: 10.1007/s00018-005-5364-0

Lieberthal AS, Carroll AE, Chonmaitree T, et al. The diagnosis and management of acute otitis media. Pediatrics. 2013;131:e964-e999. doi: 10.1542/peds.2012-3488

Wald ER, Applegate KE, Bordley C. Clinical practice guideline for the diagnosis and management of acute bacterial sinusitis in children aged 1 to 18 years. Pe­diatrics. 2013;132:e262-e280. doi: 10.1542/peds.2013-1071


GOST Style Citations


  1. Кривопустов С.П. Острый средний отит у детей: взгляд педиатра на проблему / С.П. Кри­во­пустов  // Дитячий лікар. – 2010. – № 1. – С. 12-18.
  2. Крючко Т.А. Острый средний отит у детей: сов­ременный взгляд на проблему / Т.А. Крючко, Т.В. Шпехт, О. Я. Ткаченко // Здоровье ребенка. – 2010. − № 2(23). – С. 7-10.
  3. Нестерова И.В. Проблемы лечения вирусно-бак­те­риальных респираторных инфекций у «часто и дли­тель­но болеющих» иммунокомпроментированных детей / И.В. Нестерова // Лечащий врач. - 2009. - № 6. - С.40-43.
  4. Реброва О.Ю. Статистический анализ меди­цинских данных. Применение пакета прикладных программ Statistica / О.Ю. Реброва. – Москва: Медиа Сфера, 2006. – 312 с.
  5. Сучасні можливості клінічної лабораторної діагностики / І.А. Плеш, Г.І. Кшановська, О.Й. Хомко [та ін.] // Буковин. мед. вісник. – 2014. – Т. 18, № 1 (69). – С. 147-150.
  6. Щеплягина Л.А. Возрастные особенности им­мунитета у детей / Л. А. Щеплягина, И. В. Круглова // РМЖ. – 2009. – № 23. – С. 1564.
  7. Fokkens, W. J. European position paper on rhino­sinusitis and nasal polyps / W.J. Fokkens, V.J. Lund, J. Mul­lol // Rhinology. – 2007. − Vol. 45, Suppl. 20. – Р. 84-85.
  8. Lopez Campos, Х. Risk factors for recurrent up­per respiratory infections in preschool children / X. Lopez Campos, M. Alvarez Castello, J. Massip // World Allergy Organ J. – 2012. − N 5, Suppl. 2. – Р. S101. doi: 10.1097/01.WOX.0000412013.14727.54
  9. Schroder J.M. Antimicrobial skin peptides and proteins / J.M. Schroder, J. Harder // Cellular Mo­lecular Life Sciences. − 2006. – Vol. 63. – P. 469-486. doi: 10.1007/s00018-005-5364-0
  10. The diagnosis and management of acute otitis media / A.S. Lieberthal, A.E. Carroll, T. Chonmaitree [et al.] // Pediatrics. – 2013.− Vol. 131. – Р. e964-e999. doi: 10.1542/peds.2012-3488
  11. Wald E.R. Clinical practice guideline for the dia­gnosis and management of acute bacterial sinusitis in chil­dren aged 1 to 18 years / E.R. Wald, K.E. Applegate, C. Bordley // Pediatrics. – 2013. − Vol. 132. – Р. e262-e280. doi: 10.1542/peds.2013-1071. 




DOI: https://doi.org/10.26641/2307-0404.2017.3.111931

Refbacks

  • There are currently no refbacks.