DOI: https://doi.org/10.26641/2307-0404.2017.3.111938

Forecasting of development of acute poisonings in agricultural workers while using combined formulations based on difenoconazole.

P. V. Stavnichenko, A. M. Antonenko, V. G. Bardov

Abstract


In the general structure of occupational diseases, a large proportion belongs to acute poisoning with pesticides (mainly group cases). However, today it is impossible to drop the use of pesticides in agriculture. Their application ensures high biological and economic efficiency of the latter, reduces losses of the yield. The purpose of the work was to predict the possibility of acute toxic effects in agricultural workers when working with combined formulations based on difenoconazole. Materials and methods. To assess the influence on the organism of the workers of the above-mentioned substances and formulations on their basis, the coefficient of inhalation poisoning possibility (CIPP), the coefficient of selective action of the pesticide in inhalation effect (CSAing) and the selective action of the pesticide in the dermal effect (CSAderm) were calculated. Results. Calculated values of CSAing (103.4-4701.2) and CSAderm (237.4-12345.7) for all investigated active substances were more than 100, this indicates to a rather high selectivity of their action. By the CSAing value formulations Celeste Top, Celeste Trio, Dinali, Cydeli Top belong to pesticides with a relatively low selectivity of action when they are inhaled by workers in the process of crops treating, the remaining formulations have a sufficient selectivity of action in inhalation intake. In addition, it should be noted that in general, for all combined preparations CSA values are significantly lower than for separateactive ingredients, in addition to the above assumption, can be explained by the presence of other formulants in the preparation that may have not significant but toxic effect on the body of workers. All investigated substances in the probability of occurrence of acute poisoning with the use of combined preparations on their basis are related to the 4th grade of danger according to State Standards 8.8.1.002-98. There was proved relative safety in case of penetration into the organism of agricultural workers by percutaneous and inhalational way of all studied active ingredients and most of the formulations on their basis.


Keywords


difenoconazole; combined formulations; acute poisoning; risk; action selectivity

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References


Balan GM, Kharchenko OA, Bubalo NM. [Rea­sons, structure and clinical symptoms of acute poisoning with pesticides in agricultural workers in terms of agriculture reform]. Suchasnі problemi toksikologії, khar­chovoї ta khіmіchnoї bezpeki. 2013;4:22–29. Ukrainian.

[Hygienic classification of pesticides according to the degree of danger]: DSanPiN 8.8.1.002-98. [Approv. 28.08.98]. Кyiv: Ministry of health ofUkraine, 1998;20. Ukrainian.

Gornostay OB. [The development of occupational diseases inUkraine]. Naukoviy vіsnik NLTU Ukraїni. 2013;23(16):396-401. Ukrainian.

StorchousI.[Ecology and pesticides]. Available from: http://www.agro-business.com.ua/agronomiia-sio­godni/838-ekologiia-i-pestytsydy.html. Ukrainian.

Kharchenko OA, Balan GM,BabichVA, et al. [Acute pesticide poisoning in the structure of occupa­tional morbidity in agricultural workers]. Suchasnі problemi toksikologії. 2011;5:150-151. Russian.

[Official Site of Social Insurance Fund from industrial accidents and occupational diseasesUkraine]. Available from: http://www.social.org.ua. Ukrainian.

Sergeev SG, Chayka YuG. [Assessment of the possibility of acute toxic effects when working with pesticides, taking into account their selectivity of action]. Suchasni problemy toksykolohiyi. 2008;4:29-31. Russian.

Sokolova MP. [Problems of identification and registration of occupational diseases inUkraine], [dis­sertation]. Kyiv, 2009;20. Ukrainian.

Stavnіchenko PV, Antonenko AM, Korshun MM, et al. [Toxicological and hygienic regulation and hazard evaluation of a new fungicide – cyflufenamide]. Medicnі perspektivi. 2016;XXI(2):106-11. Ukrainian.


GOST Style Citations


1.       Балан Г.М. Причини, структура та клінічні синдроми гострих отруєнь пестицидами у працівників сільського господарства в умовах його реформування / Г.М. Балан, О.А. Харченко, Н.М. Бубало // Сучасні проблеми токсикології, харчової та хімічної безпеки. – 2013. – № 4. – С. 22–29.

2.       Гігієнічна класифікація пестицидів за сту­пенем небезпечності: ДСанПіН 8.8.1.002-98. – [Затв. 28.08.98]. – Київ: М-во охорони здоров’я України, 1998. – 20 с.

3.       Горностай О.Б. Розвиток професійних за­хворювань в Україні / О.Б. Горностай // Наук. вісник НЛТУ України. – 2013. – Вип. 23.16. – С. 396–401.

4.       Екологія і пестициди / Сторчоус І. [Електрон­ний ресурс]. – Режим доступу: http://www.agro-business.com.ua/agronomiia-siogodni/838-ekologiia-i-pestytsydy.html.

5.       Острые отравления пестицидами в структуре профессиональной заболеваемости у работников сель­ского хозяйства / О.А. Харченко, Г.М. Балан, В.А. Ба­бич [и др.] // Сучасні проблеми токсикології. – 2011. – № 5. –С. 150–151.

6.       Офіційний сайт Фонду соціального страху­ван­ня від нещасних випадків на виробництві та про­фесійних захворювань України [Електронний ресурс]. – Режим доступу: http://www.social.org.ua.

7.       Сергеев С.Г. Оценка возможности возникно­вения острых токсических эффектов при работе с пес­тицидами с учетом их избирательности действия / С.Г. Сергеев, Ю.Г. Чайка // Сучасні проблеми ток­си­кології. – 2008. – № 4. – С. 29-31.

8.       Соколова М.П. Проблеми виявлення і реєстра­ції професійних захворювань в Україні: автореф. дис. на здобуття наук. ступеня канд. мед. наук: 14.02.01 / М.П. Соколова. – Київ, 2009. – 20 с.

9.       Токсиколого-гігієнічна регламентація та оцін­ка небезпечності нового фунгіциду – цифлуфенаміду / П.В. Ставніченко, А.М. Антоненко, М.М. Коршун [та ін.] // Медичні перспективи. – 2016. – Т. XХI, № 2. – С. 106-111.