Possibilities of immunogistochemical investigation in respons prognosis to treatment and modification of treatment activities at luminal breast cancer (literature review).
DOI:
https://doi.org/10.26641/2307-0404.2017.4.117658Keywords:
breast cancer, immunohistochemical investigation, hormonal therapyAbstract
This article is concerned with both standard (estrogen and progesterone receptors, Her2/neu and Ki67) immunohistochemical investigation in hormonal therapy tactics decision for luminal breast cancer and additional investigation of such hormonal sensibility marker as cyclin D1, Bcl-2, AIB1, Her1, p53, IGF-IR, COX-2 and its influence on modified hormonal therapy impact on tumor. It was shown that tumors expressing Her2/neu, AIB1, Her1, p53 or tumors, that have more than 30% expression of cyclin D1 are resistant to antiestrogen but sensible to aromatase inhibitors. IGF-IR and COX-2 tumors are resistant to aromatase inhibitors. Metformin usage for IGF-IR hyperexpression and oxygenase selective inhibitors for COX-2 expression promotes sensibility increase for aromatase inhibitors.
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