Glycosylated hemoglobin as a forecast factor of progressing of diabetic nephropathy in patients with diabetes type 1.
DOI:
https://doi.org/10.26641/2307-0404.2017.4.117665Keywords:
diabetes mellitus, diabetic nephropathy, glomerular filtration rate, lipidogram, albuminuriaAbstract
The aim of the study was to propose a mathematical model for prediction of development of diabetic nephropathy in patients with diabetes mellitus by determining the level of glycosylated hemoglobin - as a factor in the development and progression of diabetic nephropathy. A survey of 136 patients with type 1 diabetes was performed in the endocrinology department of the OSH «Clinic of the Medical Academy», Dnipro in 2016-2017. Clinical laboratory examination included: determination of the level of glycosylated hemoglobin (HbA1c), level of blood creatinine, level of albuminuria. The GFR was calculated by the formula CKD-EPI.The obtained results of the study, using methods of correlation and regression analysis, show a clear correlation between the GFR score in patients with diabetes mellitus and the level of glycosylated hemoglobin. Statistical methods of analysis have shown that the level of glycosylated hemoglobin can be considered as an early predictor of development of diabetic nephropathy. The mathematical equation of prognosis for the onset of diabetic nephropathy can be used to determine the prognosis for the development of diabetic nephropathy in diabetes mellitus patients in clinical practice for the timely inclusion of patients with a high prognostic risk in a group requiring more stringent glycemic control.
References
Moskalenko VF. [Biostatistics]. Kyiv, Kniga plyus. 2009;184. Ukrainian.
Pan'kіv VІ. [Symposium N 156 "Diabetes Mellitus: Definition, Classification, Epidemiology, Risk Factors"]. International Endocrinology Journal. 2013;7:95-104. Ukrainian.
Rebrova OYu. [Statistical analysis of medical data. Application of the STATISTICA application package]. Moskva, Media-Sfera. 2006;312. Russian.
Sokolova LK. [Prevalence of diabetes mellitus inUkraine[Electronic resource] Telegraf. 2015. Available from: https://telegraf.com.ua/zhizn/zdorove/2195284-rasprostranennost-saharnogo-diabeta-v-ukraine-uvelichilas-v-poltora-raza.html Ukrainian.
Khardle V. [Applied non-parametric regression]. Moskva, Mir. 1993;349.
Brenner ВМ. The hyperfiltration theory: a paradigm shift in nephrology. Kidney Int. 1996;49(6):1774-7.
Diabetes Key facts. [Electronic resource]. World Health Organization. Available from: http://www.who.int/mediacentre/factsheets/fs312/en/.
DCCT/EDIC Research Group, Intensive diabetes therapy and glomerular filtration rate in type 1 diabetes N. Engl. J. Med. 2011;365:2366-76.
Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial. Lancet. 2010;376:419-30.
Patel А. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet. 2007;370:829-40.
Frische S. Glomerular filtration rate in early diabetes: ongoing discussions of causes and mechanisms. J. Nephrol. 2011;24(5):537-40.
Okada R. Glomerular hyperfiltration in prediabetes and prehypertension. Nephrol Dial Transplant. 2012;27(5):1821-5.
KDOQIUScommentary on the 2012 KDIGO clinical practice guideline for the evaluation and management of CKD. Am J Kidney Dis. 2014;63:713-35.
KrolewskiAS.Genetics of diabetic nephropathy: how far are we from finding susceptibility genes? Adv. Nephrol. Necker. Hosp. 2010;31:295-315.
Lorenzi M. Glucose toxicity in the vascular complications of diabetes: The cellular perspective. Diabet. Metab. Rev. 2009;8:85-103.
National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases,Bethesda,MD.US. Renal data system annual data report: atlas of end-stage renal disease in theUnited States; 2010.
NKF-KDOQI Guidelines on Diabetes and CKD. Am. J. Kid. Dis. 2013;2(2):12-143.
Porush JM. Hypertension, diabetes mellitus and nephropathy.London. Sience Preess. 2010;9-12.
US Hypertension Management Guidelines: A Review of the Recent Past and Recommendations for the Future. [Electronic resource]. J. Am Heart Assoc. 2015. Available from: http://jaha.ahajournals.org/content/4/12/e002315.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2017 Medicni perspektivi (Medical perspectives)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.
