Morphological characteristics of brain lesions in HIV infection.
DOI:
https://doi.org/10.26641/2307-0404.2018.1.124925Keywords:
HIV infection, pathology, morphology, brain, mortalityAbstract
Currently, diseases of the central nervous system are a common cause of death of patients with HIV infection. The article presents results of retrospective analysis of etiotropic structure of 186 lethal cases and typical pathological changes of brain tissue of patients aged 21 to 61 years who had confirmed diagnosis of HIV and died of diseases associated with CNS damage in the Municipal infectious hospital in the city ofDnepr(Ukraine) in the period from 2011 to 2016. The most common causes of death in patients with HIV infection and CNS infection were cerebral tuberculosis (75.0%) including co-infection (n = 35) and meningoencephalitis that developed as a result of yeast fungal (15.6%). In the study of neuropathological processes in the autopsy material of the brain tissue of patients with HIV, various multifocal and diffuse morphological changes have been identified that can be presented in this work in the form of 4 groups: 1) Multiple nonspecific changes associated with both direct action of HIV and co-factors : infection, inflammation, hypoxia, etc., 2) Viral-induced vasculitis with hemorrhages, 3) Subacute aseptic encephalitis, 4) HIV-associated opportunistic infections. General pathomorphological changes in brain tissue are revealed that can cause similarities of clinical manifestations, can complicate differential diagnosis of cerebral lesions of various etiologies, and lead to a divergence of pre and postmortal diagnoses.
References
[HIV infection inUkraine]. Informatsiynyy byuleten'. 2017;47:148. Ukrainian.
Zinserling VA, Komarova DV, Vasilieva MV, Karev VE. [Pathological anatomy of HIV infection based on St. Petepbupg’s materials]. Archives of Pathology. 2003;65(1):42-5. Russian.
Zinserling VA.[The most important problem of morphological diagnosis in HIV infection. HIV infection and immunosuppression]. Archives of Pathology. 2009;2:31-37. Russian.
Bilgrami M, O'Keefe P. Neurologic diseases in HIV-infected patients. Handbook of clinical neurology. 2014 Jan;121:1321-44.
Masliah E, DeTeresa RM, Mallory ME,Hansen LA.Changes in pathological findings at autopsy in AIDS cases for the last 15 years. Aids. 2000 Jan; 14(1):69-74.
Sonkar SK, Gupta A, Atam V, Chaudhary SC, Tripathi AK, & Sonkar GK. Clinical profile of neurological manifestation in Human Immunodeficiency Virus-positive patients. N Am J Med Sci. 2012 Nov;4(11):596-9. doi: 10.4103/1947-2714.103329.
Everall IP, Luthert PJ, Lantos PL. Neuronal loss in the frontal cortex in HIV infection. The Lancet. 1991;337(8750):1119-21.
Bolokadze N, Gabunia P, Ezugbaia M, Gatserelia L, Khechiashvili G. Neurological complications in patients with HIV/AIDS. Georgian Med News. 2008;165:34-8.
Santosh V, Shankar SK, Das S, Pal L,RaviV, Desai A, Swamy HS. Pathological lesions in HIV positive patients. Indian J Med Res. 2013 Jun; 37(6):1219-26.
Downloads
How to Cite
Issue
Section
License
Copyright (c) 2018 Medicni perspektivi
This work is licensed under a Creative Commons Attribution 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.
