Molecular-genetic testing of single-nucleotide polymorphism C-33T of IL4 gene in children with recurrent episodes of acute obstructive bronchitis.

O. V. Kens, O. Z. Gnateyko, N. S. Lukyanenko, V. I. Bergtravm

Abstract


The molecular genetic testing of the IL4 gene of a single nucleotide polymorphism C-33T was performed in 35 children with recurrent episodes of acute obstructive bronchitis and 35 children with acute bronchitis. It has been proved that the presence of a child's genotype 33СT IL4 increases the risk of recurrent acute obstructive bronchitis by 4 times.


Keywords


molecular genetic testing; children; IL4 gene C-33T polymorphism; repeated episodes of acute obstructive bronchitis

References


Zhukova OV, Kononova SV, Konyushkina TM. [Distribution of expenses for pharmacotherapy of acute obstructive bronchitis in children in real clinical practice, taking into account pharmacoeconomic studies]. Farma­teka. 2013;18:29-33. Russian.

Zhdan VM, Gurіna LІ, Babanіna Myu, et al. [Di­seases of the respiratory organs in the practice of a family doctor].Poltava. 2008;3. Ukrainian.

Malanicheva TG, Zakirova AM, Ovchinniko­va AG. [Therapy of recurrent bronchitis in children with frequent respiratory diseases, with disturbances in the microbiocenosis of the nasopharynx]. Lechashchiy vrach. 2014;9:26-29. Russian.

Trajkov D, Mirkovska-Stojkovikj J, Petlichkovski F. Association of cytokine gene polymorphisms with chronic obstructive pulmonary disease in Macedonians.IranJ Allergy Asthma Immunol. 2009;8(1):31-42.

Smolnikova M, Smirnova S, Freidin M and other. Immunological parameters and gene polymorphisms (C-590T IL4, C-597A IL10) in severe bronchial asthma in children from theKrasnoyarskregion, westSiberia. Int J Circumpolar Health. 2013;72:72-78.

Miyake Y, Tanaka К, Arakawa М and other. Re­lationship between polymorphisms in IL4 and asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health Study. J Investig Allergol Clin Immunol. 2013;23(4):242-7.

Yang HJ. Association between the interleukin-4 gene C-589T and C-33T polymorphisms and asthma risk: a meta-analysis. Med Res Arch. 2013;44:127-35.


GOST Style Citations


  1. Жукова О.В. Распределение расходов на фар­макотерапию острого обструктивного бронхита у детей в реальной клинической практике с учетом фармакоэкономических исследований / О.В. Жукова, С.В. Кононова, Т.М. Конюшкина // Фарматека. – 2013. – № 18. – С. 29-33.
  2. Захворювання органів дихання в практиці сі­мейного лікаря / В.М. Ждан, Л.І. Гуріна, М.Ю. Баба­ніна [та ін.]. – Київ; Полтава, 2008. –3 с.
  3. Маланичева Т.Г. Терапия рецидивирующих бронхитов у детей с частыми респираторными заболе­ваниями, имеющих нарушения микробиоценоза носо­глотки / Т.Г. Маланичева, А.М. Закирова, А.Г. Овчин­никова // Лечащий врач. – 2014. – №. 9. – С. 26-29.
  4. Trajkov D. Association of cytokine gene poly­morphisms with chronic obstructive pulmonary disease in Macedonians / D. Trajkov, J. Mirkovska-Stojkovikj, A. Petlichkovski //Iran. J. Allergy, Asthma Immunol. – 2009. – Vol. 8, N 1. – P. 31-42.
  5. Immunological parameters and gene polymo­rphisms (C-590T IL4, C-597A IL10) in severe bronchial asthma in children from the Krasnoyarsk region, west Si­beria / M. Smolnikova, S. Smirnova, M. Freidin [et al.] // In­ter. J. Circumpolar Health. – 2013. – Vol. 72. – P. 72-78.
  6. Relationship between polymorphisms in IL4 and asthma in Japanese women: the Kyushu Okinawa Ma­ternal and Child Health Study / Y. Miyake, К. Tanaka, М. Arakawa [et al.] // J. Investigational Allergol. Clin. Im­munol. – 2013. – Vol. 23, N 4. – P. 242-247.
  7. Yang H. J. Association between the interleukin-4 gene C-589T and C-33T polymorphisms and asthma risk: a meta-analysis / H. J. Yang // Arch. Med. Res. – 2013. – Vol. 44. – Р. 127-135.




DOI: https://doi.org/10.26641/2307-0404.2018.1(part1).127212

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