Comparative evaluation of genetic risk models of reproductive disorders caused by MTHFR, MTRR, MTR1 gene polymorphism.

Z. І. Rossokha, S. P. Kyriachenko, N. G. Gorovenko

Abstract


The scientific literature presents contradictory data about influence of folate metabolism genes polymorphism on development of risk of reproductive disorders. The aim of the study was to determine the role of MTHFR, MTRR, MTR1 gene polymorphism in the development of reproductive disorders by evaluation of genetic risk models of inheritance. 658 patients with reproductive disorders from all Ukrainian regions were examined. The data from population studies presented in the online resource (1000 genomes) served as comparison group. There were no reliable risk models for polymorphic variants of MTHFR gene. We identified 3 and 4 significant inheritance models for MTRR and MTR1 genes respectively. The best inheritance models were the dominant model for MTRR gene and the additive model for MTR1 gene. The polymorphic variants frequencies of the studied genes did not differ among men and women. Further analyse is necessary for evaluation of genetic polymorphism and intergenic interactions influence on reproductive disorders risk, taking into account folate metabolism indices and exogenous factors.


Keywords


inheritance models; reproductive disorders; polymorphic variants; MTHFR; MTRR; MTR1; genes

References


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Rossokha ZI, Kyriachenko SP, Gorovenko NG. [Diagnosis and treatment of hereditary thrombophilia in obstetric and gynecological practice]. Medychni aspekty zdorovia zhinky. 2014;6(81):5-13. Ukrainian.

Kurzawski M, Wajda A, Malinowski D, Kazien­ko A, et al. Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish popula­tion. Genetics and Molecular Biology. 2015;38(1):42-47.

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Hozyasz K, Mostowska A, Szaflarska-Poplaws­ka A, et al. Polymorphic variants of genes involved in ho­mocysteine metabolism in celiac disease. Molecular Biology Reports. 2011;39(3):3123-30.

Liu K, Zhao R, Shen M, et al. Role of genetic mu­tations in folate-related enzyme genes on Male Infertility. Scientific Reports. 2015;5(1). doi: 10.1038/srep15548


GOST Style Citations


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  6. MTHFR C677T, A1298C and MS A2756G Gene Polymorphisms and Male Infertility Risk in a Chinese Population: A Meta-Analysis / Z. Ren, P. Ren, B. Yang [et al.] // PLOS ONE. – 2017. – Vol. 12. – P. e0169789.
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  8. Role of genetic mutations in folate-related en­zyme genes on Male Infertility / K. Liu, R. Zhao, M. Shen [et al.] // Scientific Reports. – 2015. – Vol. 5, N 1. doi: 10.1038/srep15548




DOI: https://doi.org/10.26641/2307-0404.2018.2.133943

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