Clinical and pathogenetic substantiation of the use of Wobenzim in the complex treatment of generalized periodontitis.
Keywords:generalized periodontitis, wobenzym, monotherapy
The purpose of this study was to determine the efficacy of using Wobenzim as a general therapy in the complex treatment of generalized periodontitis. 61 patients, I-II degree of severity, with tooth safety in an amount of at least 90%, without concomitant general pathology requiring treatment for the current time were examined. Comparative effectiveness of treatment was studied in 2 groups similar in all clinical indices. The main (31 people) patients, along with the symptomatic treatment received Wobenzim; control (30 people) - polytherapy (immunocorrecting, antioxidant, antimicrobial agents). As a result of the generally accepted clinical, paraclinical, immunological and biochemical studies conducted during the treatment and at long-term follow-up, it was found that the use of systemic enzyme therapy in this category of patients ensures rapid regression of the main clinical symptoms (on days 6-7), elimination of pathogenetic links of the disease more than in 90% of treated patients and the onset of remission for at least 6-12 months. It is characteristic that during the monotherapy with Wobenzim, positive results of treatment of generalized periodontitis were achieved, similar to those with the use of complex standard therapy, including administration of a number of medications with targeted action on pathogenesis mechanisms of the disease. From the position of evidence-based medicine, the expediency of replacing a broad arsenal of medicines in the complex treatment of generalized periodontitis with certain pharmacological preparations with a systemic effect is justified.
Gudaryan AA, Shandyba SI. [Efficiency of local differentiated use of membranes in the surgical treatment of generalized periodontitis in patients with type 2 diabetes mellitus]. Visnyk stomatologii. 2014;3:79-83. Russian.
Gumeniuk MI. [Peculiarities of parodontologic status and local immunity of the oral cavity in patients with chronical obstructive diseases of lungs]. Novyny stomatologii. 2015;4:71-76. Ukrainian.
Demkovich AY. [Pathogenetic role of microbial persistence of a dental plaque in the mechanisms of development of generalized periodontitis: (literature review)]. Journal Clinic and experiment. honey. research. 2015;3(2):174-80. Ukrainian.
Dimitrova AG. [The prevalence and intensity of periodontal diseases in students of NMU]. Sovrem. stomatologiya. 2015;3:23-25. Russian.
Dolzhikova EM, Sternin YuI Shuginina EA. [Pathogenetic substantiation and experience of application of systemic enzyme therapy in cosmetology and plastic surgery]. Regular issues of "RMZh". 2011;11:698. Russian.
Zorina OA, Kulakov AA, Grudyanov AI. [Microbiocenosis of the oral cavity in norm and with inflammatory periodontal diseases]. Stomatologiya. 2011;1:73-78. Russian.
Knorring GYu, Remezov AP. [The use of systemic enzyme therapy for the treatment of infectious diseases]. Terramedica. 2004;4:6-8. Russian.
Kulakova VI,NasonovaVA, Savel'eva VS. [Systemic enzyme therapy. Experience and prospects]. Sankt-Peterburg, Inter-Medika, 2004;264. Russian.
Mashchenko IS. [Inflammatory and dystrophic periodontal diseases: manual]. Dnipropetrovsk, ART-PRES. 2003;244. Ukrainian.
Mashchenko IS, Gudaryan AA. [Immunopathogenesis of various clinical forms of generalized periodontitis]. Visnyk stomatologii. 2012;2:41-46. Ukrainian.
Mashchenko IS, Gudaryan AA,DoroginaAS.[Causes of resistance of the main periodontal pathogens to antibacterial therapy in patients with fast-progressive generalized periodontitis]. Visnyk stomatologii. 2013;4:35-41. Russian.
http://irbis-nbuv.gov.ua/cgi-bin/irbis64r_81/cgiirbis_64.exe?Z21ID=&I21DBN=REF&P21DBN=REF&S21STN=1&S21REF=10&S21FMT=fullwebr&C21COM=S&S21CNR=20&S21P01=0&S21P02=0&S21P03=A=&S21COLORTERMS=1&S21STR=%D0%9C%D1%83%D1%85%D1%96%D0%BD%20%D0%86$">Mukhin IV. [Antioxidant effect of Wobenzim in patients with chronic glomerulonephritis]. Likarska sprava. 2007;1-2:58-61. Ukrainian.
Pashaev AC, Puri-Zahidan SV. [Antibacterial therapy of chronic generalized periodontitis]. Visnyk stomatologii. 2014;4:93-97. Russian.
Sternin YuI, Mikhaylov IB. [Selected Issues in Clinical Pharmacology of Systemic Enzymotherapy: A Handbook for Physicians]. Sankt-Peterburg, InformMed. 2010;32. Russian.
Chuykin SV, Khasanov TA, Baimukhametov A. [The use of the drug Vobenzim in the complex treatment of acute purulent lymphadenitis of the maxillofacial region in children]. Medical Bulletin of Bashkortostan. 2011;6:82-84. Russian.
Ramseier CA. [Advanced reconstructive technologies for periodontal tissue repair]. Periodontal. 2000. 2012;59:185-202.
Aditi Mathur, Lalit Mathur, Balaji Manohar, Hemant Mathur, Rajesh Shankarapillai, Neema Shetty, and Aman Bhatia. [Antioxidant therapy as monotherapy or as an adjunct to treatment of periodontal diseases]. J Indian Soc Periodontol. 2013;17(1): 21-24.
Plessas A. [Nonsurgical periodontal treatment: review of the evidence]. Oral health dent. manag. 2014;13(1):71-80.
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