Infectious exacerbation of chronic obstructive pulmonary disease: place and role of respiratory viral pathogens.
DOI:
https://doi.org/10.26641/2307-0404.2019.4.189191Keywords:
chronic obstructive pulmonary disease, infectious exacerbation, respiratory viral pathogens, rapid immunochromatographic tests, real-time multiplex PCRAbstract
To determine the prevalence and spectrum of viral pathogens in patients with infectious exacerbation (IE) of chronic obstructive pulmonary disease (COPD), 106 patients were examined, who underwent a virological examination using fast immunochromatographic tests (IC-tests), as well as real-time multiplex polymerase chain reaction (PCR) with the simultaneous identification of 12 respiratory viruses. Respiratory viruses, as the etiological factor of IE COPD were identified in (65.9 ± 4.7)% of patients. Among viral pathogens adenovirus and rhinovirus - in (24.5±6.1)% of cases each and parainfluenza virus - in (18.4±4.6)% were of greatest etiological significance for the entire observation period. The influenza A and B virus was detected much less frequently - in (8.2±3.9)% and in (4.1±2.8)% of cases, respectively; respiratory syncytial virus and bocavirus – in (6.1±3.4)% and metapneumovirus – in (8.2±3.9)% of cases. The last two types of viruses were detected in Ukraine for the first time. The spectrum of viral pathogens of IE COPD depended on the seasonal circulation of a particular type of virus, the epidemiological situation in the region, and the characteristics of the examined population. The use of modern virological diagnostic technologies testifies to the leading role of respiratory viruses in the etiology of IE COPD аnd also allows the etiological diagnosis to be established in a short period of time – from 10-15 minutes when using fast IC-tests and up to 6-8 hours – when using real-time multiplex PCR, which contributes to the timely administration of adequate etiotropic treatment.
References
Dziublyk IV, Solovyov SO, Kovaluk OV. [Operational characteristics of the effectiveness of modern tests in the etiological diagnosis of viral infections and their interpretation]. Preventivna Medicina. 2017;3-4(29):103-121. Ukrainian.
Dziublyk YaO. [Non-hospital infections of the lower respiratory tract]. Vinnytsia: Mercury-Podillya. 2016;255. Ukrainian.
Lapach SM, Chubenko AV, Babich PM. [Statistical methods in biomedical research using Excel]. Kyiv: MORION; 2000. p. 320. Russian.
Pertseva TO, Plekhanova OV. [Analysis of causes and structure of exacerbation of chronic obstructive pulmonary disease]. Medicni Perspektivi. 2009;14(2):53-58. Ukrainian.
Dziublyk IV, Gorovenko NG. [Polymerase chain reaction in laboratory diagnostics of infectious diseases: a textbook]. Kyiv. 2012;219. Ukrainian.
Rachina SA, Kozlov RS. [Modern approaches to microbiological diagnosis in community-acquired pneumonia]. Pulmonologiya. 2010;1:5-14. Russian.
Sinopalnikov AI, [Community-acquired infections of the respiratory tract: approaches to rational antibiotic therapy]. Consilium Medicum. 2017;19):45-51. Russian. doi: https://doi.org/10.26442/2075-1753_19.11.1.45-51
Feshchenko YuI, et al. [Chronic obstructive pulmonary disease] Kyiv: NAMNU; 2019. p. 67. Ukrainian.
Decramer M, Janssens W, Miravitlles M. Chronic obstructive pulmonary disease. Lancet. 2012;379:1273–1364. doi: https://doi.org/10.1016/S0140-6736(11)60968-9
Bordon J, et al. Early administration of the first antimicrobials should be considered a marker of optimal care of patients with community-acquired pneumonia rather than a predictor of outcomes. Int J Infect Dis. 2013;(17 Suppl. 5):293-298. doi: https://doi.org/10.1016/j.ijid.2012.09.021
Lozano R, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the global burden of disease study 2010.Lancet. 2012 Dec 15;380(9859):2095-128. doi: https://doi.org/10.1016/S0140-6736(12)61728-0
Woodhead M, et al. Guidelines for the management of adult lower respiratory tract infections.Clin Microbiol Infect. 2011;(17 Suppl 6):E1-59. doi: https://doi.org/10.1111/j.1469-0691.2011.03672
Abdeldaim GM, et al. Quantitative fucK gene polymerase chain reaction on sputum and nasopharyngeal secretions to detect Haemophilus influenzae pneumonia. Diagn Microbiol Infect Dis. 2013;(76 Suppl. 2):141–146. doi: https://doi.org/10.1016/j.diagmicrobio.2013.02.015
Wedzicha J, et al. Management of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline. Eur Respir J. 2017;49(3):1600791. doi: https://doi.org/10.1183/13993003.00791-2016
Willson J, et al. The Aetiology of Acute Exacerbations in Chronic Obstructive Pulmonary Disease (AECOPD): A Systematic Literature Review (SLR). Eur Respir J. 2018;(52 Suppl.):PA4091. doi: https://doi.org/10.1183/13993003.congress-2018.PA4091
Downloads
How to Cite
Issue
Section
License
Copyright (c) 2019 Medicni perspektivi (Medical perspectives)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.
