Dynamics of IL-4 and IFN-γ cytokine profile under the influence of combined allergen-specific immunotherapy (ASIT) in patients with polynosis and combined sensitization to pollen and household allergens.

Authors

DOI:

https://doi.org/10.26641/2307-0404.2020.1.200410

Keywords:

polynosis, cytokines, combined allergen-specific immunotherapy

Abstract

The article presents the results of the clinical evaluation of the  cytokine profile  (IL-4, IFN-γ) in combined allergen-specific ASIT immunotherapy in patients with polynosis and combined sensitization to pollen and household allergens. Studies were conducted in 49 patients aged 19-57 years (24 women and 25 men) suffering from polynosis from 1 to 38 years. Patients underwent an allergological examination, including history taking, diagnostic skin tests - prick test, immunological studies of blood by enzyme-linked immunosorbent assay and allergic component diagnosis ALEX, on the basis of which polysensitization to pollen and household allergens was revealed in all patients. All patients underwent pre-season ASIT. The main group of 31 patients received a combined ASIT with solutions of pollen and household allegens. 18 patients of the comparison group received ASIT only with pollen allergens. The observation groups were comparable by sex, age, and disease duration. Studies were conducted during the period of remission of the disease before the onset of ASIT and 1 year after. It was found that under the influence of combined ASIT, an immunospecific effect was observed in patients with a significant decrease in the level of IL-4 in simultaneous increase in the production of interferon-gamma by 59.8%, which indicates the activation of the process of switching the immune response from Th-2 to Th-1 cells. The positive results of clinical and immunological studies convincingly prove the advantages and effectiveness of the use of ASIT in patients with polynosis and combined sensitization to pollen and household allergens.

Author Biographies

E. M. Dytyatkovska

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» 
Department of Occupational Diseases and Clinical Immunology
Department of Family Medicine FPE
V. Vernadsky str., 9, Dnipro, 49044, Ukraine 

S. V. Biletska

Medical Center “Unimed” 
Mlodej Polski str., 7, Krakow, 30-131, Poland

References

Antomonov MYu. [Mathematical processing and analysis of biomedical data]. Medinform. 2018;579. Russian.

Dityatkovska EM. [The dynamics of cytokines in cases of illness on polynoz pіd in a rush of riznyh courses ASIT]. Immunology and allergology, science and prac­tice. 2011;2:61-66. Ukrainian.

Dityatkovska EM. [Epidemiological patterns of pollinosis in Dnepropetrovsk]. Rhinology. 2012;1:13-19. Ukrainian.

Dityatkovska EM. [Efficiency of different methods and other courses of ASIT in patients with polynosis]. Medicni perspektivi. 2012;17(3):22-30. Ukrainian.

Dityatkovska EM. [The temperament and the nature of the dynamics of the cytokine rіvnya pіd vlivno ACІT in ill with polynoz]. Medicni perspektivi. 2011;15(2):54-59. Ukrainian.

Dytyatkovska E, Gashynova K, Panov V. Patterns of molecular sensitization in adults in Dnipro region (Ukraine). Allergy. 2019;74:831-2. doi: https://doi.org/10.1111/all.13998. ISNN 1398-9995

Rondón C, Campo P, Salas M, Aranda A, Molina A, González M, Galindo L, Mayorga C, Torres MJ, Blanca M. Efficacy and safety of D. pteronyssinus immu­notherapy in local allergic rhinitis: a double‐blind placebo‐controlled clinical trial. 2016. 23 March;71(7):1057-61. doi: https://doi.org/10.1111/all.12889

Jutel M, Agache I, Bonini S, et al. International consensus on allergy immunotherapy. J Allergy Clin Immunol. 2015;136:556­68. doi: https://doi.org/10.1111/all.13973

Milena Sokolowska, Tadech Boonpiyathad, Maria M. Escribese, Domingo Barber. Allergen‐specific immu­notherapy: Power of adjuvants and novel predictive biomarkers. Allergy. 2019;74(11):2061-3 doi: https://doi.org/10.1111/all.13973

Roberts G, Pfaar O, Akdis CA, et al. EAACI Guidelines on Allergen Immunotherapy: allergic rhinoconjunctivitis. Allergy. 2018;73:765-98. doi: https://doi.org/10.1111/all.13317

Ullrich D, Ullrich K, Mussler S, Thum-Oltmer S. Vaccination during concurrent subcutaneous immu­notherapy: safety of simultaneous application. Eur Ann Allergy Clin Immunol. 2015;47:10-4. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25599553

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Published

2020-04-09

How to Cite

1.
Dytyatkovska EM, Biletska SV. Dynamics of IL-4 and IFN-γ cytokine profile under the influence of combined allergen-specific immunotherapy (ASIT) in patients with polynosis and combined sensitization to pollen and household allergens. Med. perspekt. [Internet]. 2020Apr.9 [cited 2024Apr.24];25(1):116-21. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/200410

Issue

Vol. 25 No. 1 (2020)

Section

CLINICAL MEDICINE

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