Prognosis of cellular energy metabolism shifts in adolescents with community-acquired pneumonia

Authors

DOI:

https://doi.org/10.26641/2307-0404.2021.1.227956

Keywords:

community acquired pneumonia, children, cellular energy metabolism

Abstract

Pneumonia is one of the most severe respiratory pathology forms in children, which contributes significantly to infant mortality. The high risk of chronic bronchopulmonary process and child`s disability, in case of severe and complicated disease, requires careful pathophysiological change's analysis in community-acquired pneumonia (CAP) in children. In particular, for the prediction of these disorders in children with CAP are important the dysmetabolic phenomena study and the specific approaches development. The immediate aim of this work is to study the cellular energy metabolism (CEM) features and to develop approaches for the early bioenergetic disorders diagnostics in conditions of community-acquired pneumonia in adolescents.The aim of the study is to develop approaches for the early diagnosis of shifts in energy metabolism in children aged 14-18 years with CAP. An examination of 41 children aged 14-16 years with the definition of CEM indicators was conducted in order to develop an approach for predicting CEM disorders in community-acquired pneumonia using the method of logistic regression. A logistic regression method was used to develop a method for predicting CEM disorders in children with CAP. The characteristics of CEM in children with CAP were determined. A decrease in the succinate dehydrogenase activity and an increase in the lactate dehydrogenase / succinate dehydrogenase ratio in children with CAP relative to the reference parameters were observed, which indicated an inhibition of the anaerobic energy synthesis pathway. Two mathematical models for predicting CEM disorders in CAP based on logistic regression equations were proposed. The first mathematical model consisted of social and health characteristics and of pneumonia clinical course characteristics. In ROC analysis the area under the curve (AUC) was 0.82, diagnostic specificity – 71%, diagnostic sensitivity – 90%. The second model included only hematological parameters, AUC – 0.78, diagnostic specificity – 69%, diagnostic sensitivity – 81%. Thus, changes in CEM in children with CAP aged 14 – 18 years have been established. Two methods for predicting disorders of CEM in children with CAP have been developed, which can be applied to optimize the treatment of children with CAP aged 14-18 years.

References

Khunderyakova NV, Yachkula TV, Fedotcheva NI, Litvinova EG, Sсhwartsburd PM, Kondrashova MN, Zakharchenko MV, Plyasunova SA, Sukhoru¬kov VS, Baranich TI. [A highly sensitive non-damaging method for detecting the mitochondria state by examining the blood lymphocytes smears of hte children with leukemia and myopathy compared to healthy children in order to detect significant differences]. Meditsinsky alfavit. 2017;20(2):27-30. Russian. doi: https://doi.org/10.33667/2078-5631

Li LA. [Application of metabolic energy therapy to correction energy deficit of immune cells in children with community-acquired pneumonia]. Byuleten fizio¬logii i patologii dykhaniya. 2015;57:35-41. Russian. doi: https://doi.org/10.12737/20122

Loyda Z, Gossrau R, Shibler TM. [Histochemistry of enzymes]. Moskva: Mir. 1982;272. Russian.

Nasibullin BA, Koval LI, Koretska HO. [Cyto-energetic status in children with community-acquired pneumonia]. Suchasna pediatriia. 2018;6(94):33-36. Ukranian. doi: https://doi.org/10.15574/SP.2018.93.33

Savchenko AA, Grinshteyn YuI, Dresvyankina LV, Aristov AI. [Chemiluminescent and enzymatic activity of blood neutrophils in patients with varying degrees of severity the community-acquired pneumonia]. Sibirskoe meditsinskoe obozrenie. 2015;5(95):55-61. Russian. doi: https://doi.org/10.20333/2500-0136

Cheng HL, Amatoury M, Steinbeck K. Energy expenditure and intake during puberty in healthy nonobese adolescents: a systematic review. Am J Clin Nutr. 2016 Oct;104(4):1061-74. doi: https://doi.org/10.3945/ajcn.115.129205

Ambroggio L, Florin TA, Shah SS, Ruddy R, Yeomans L, Trexel J, Stringer KA. Emerging Biomarkers of Illness Severity: Urinary Metabolites Associated with Sepsis and Necrotizing Methicillin-Resistant Staphylococcus aureus Pneumonia. Pharmacotherapy. 2017 Sep;37(9):1033-42. doi: https://doi.org/10.1002/phar.1973

Zheng Y, Ning P, Luo Q, He Y, Yu X, Liu X, Chen Y, Wang X, Kang Y, Gao Z. Inflammatory responses relate to distinct bronchoalveolar lavage lipidome in community-acquired pneumonia patients: a pilot study. Respir Res. 2019 May 2;20(1):82. doi: https://doi.org/10.1186/s12931-019-1028-8

Karakioulaki M, Stolz D. Biomarkers in Pneumonia-Beyond Procalcitonin. Int J Mol Sci. 2019 Apr 24;20(8):2004. doi: https://doi.org/10.3390/ijms20082004

Korytko Z, Kulitka E, Chornenka H, Zachidnyy V. Use of integral hematological indices for diagnostics of athletes’ adaptive processes. Journal of Physical Education and Sport. 2019 Jan;19(1):214-18. doi: https://doi.org/10.7752/jpes.2019.s1032

Ning P, Zheng Y, Luo Q, Liu X, Kang Y, Zhang Y, Zhang R, Xu Y, Yang D, Xi W, Wang K, Chen Y, An S, Gao Z. Metabolic profiles in community-acquired pneumonia: developing assessment tools for disease severity. Crit Care. 2018 May 14;22(1):130. doi: https://doi.org/10.1186/s13054-018-2049-2

Antcliffe D, Jiménez B, Veselkov K, Holmes E, Gordon AC. Metabolic Profiling in Patients with Pneumonia on Intensive Care. EBioMedicine. 2017 Apr;18:244-53. doi: https://doi.org/10.1016/j.ebiom.2017.03.034

Ranganathan P, Pramesh CS, Aggarwal R. Common pitfalls in statistical analysis: Logistic regression. Perspect Clin Res. 2017 Jul-Sep;8(3):148-51. doi: https://doi.org/10.4103/picr

Adamko DJ, Saude E, Bear M, Regush S, Robinson JL. Urine metabolomic profiling of children with respiratory tract infections in the emergency department: a pilot study. BMC Infect Dis. 2016 Aug 22;16(1):439. doi: https://doi.org/10.1186/s12879-016-1709-6

Downloads

Published

2021-03-26

How to Cite

1.
Zubarenko O, Stoieva T, Koval L, Kopiyka G, Papinko R. Prognosis of cellular energy metabolism shifts in adolescents with community-acquired pneumonia. Med. perspekt. [Internet]. 2021Mar.26 [cited 2022Jul.6];26(1):143-9. Available from: http://journals.uran.ua/index.php/2307-0404/article/view/227956

Issue

Section

CLINICAL MEDICINE

Most read articles by the same author(s)