The use of extemporal dosage form with pyroctone olamine in the complex treatment of patients with seborrheic dermatitis

Authors

  • I.V. Odintsova SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine», Department of Skin and Venereal Diseases, V. Vernadsky str., 9, Dnipro, 49044, Ukraine , Ukraine https://orcid.org/0000-0001-8234-7638
  • A.D. Diudiun SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine», Department of Skin and Venereal Diseases, V. Vernadsky str., 9, Dnipro, 49044, Ukraine , Ukraine https://orcid.org/0000-0002-8374-3023

DOI:

https://doi.org/10.26641/2307-0404.2021.1.228005

Keywords:

seborrheic dermatitis, Malassezia spp., Complex treatment, pyrocton olamine

Abstract

The purpose of the work is to evaluate the efficacy and tolerance of extemporal dosage form with pyroctone olamine in the local treatment of patients with seborrheic dermatitis. Under our supervision there were 78 patients with seborrheic dermatitis aged 18 to 57 years. The average age of the patients was 29.5±2.1 years. Comprehensive treatment of patients with seborrheic dermatitis in both groups depended on the severity of clinical manifestations, the duration of the disease, and information on the effectiveness of previous therapy. For external treatment of the main group of patients with seborrheic dermatitis, an extemporaneously prepared gel with pyrocton olamine was used. Local treatment of patients in the comparison group consisted of the appointment of 1% cream of clotrimazole. An analysis of the results shows good therapeutic, microbiological effectiveness and good tolerance of extemporaneously prepared gel with pyrocton olamine in the complex treatment of patients with seborrheic dermatitis. The period for resolving the clinical manifestations of seborrheic dermatitis among patients in the main group was 2.5±0.1 days shorter compared with patients in the comparison group. The intensity of clinical manifestations in patients with seborrheic dermatitis of the main group decreased twice on the second day of complex treatment. In control patients with comparative seborrheic dermatitis, similar therapeutic efficacy was achieved on the fourth to fifth day. Long-term results of the study showed that the recurrence of the disease among patients of the main group was 5 (6.4%), and in patients of in the comparison group was 14 (17.9%). Clinical studies have shown good therapeutic efficacy and tolerance of the extemporal gel with pyroctone olamine in the complex treatment of patients with seborrheic dermatitis, which gives reason to recommend this dosage form for wider use in the practice of dermatovenerologists.

References

Albanova VI, Kalinina OV. [Seborrhea dermatitis of the scalp: the role of Malassezia]. Advances in medical mycology. 2016;14:11-14. Russian.

Antomonov MYu. [Mathematical processing and analysis of biomedical data]. 2017. p. 578 Russian.

Ivchenko GI, Medvedev YuI. [Introduction to Mathematical Statistics. "Statistics knows everything"]. URSS. 2017. p. 608. ISBN 978-5-9710-4535-9. Russian.

Kamyshnikov VS. [Clinical laboratory research methods]. MEDpress-inform; Kyiv. 2020;736:210. Russian.

Narozhna MV. [Rozladi intestinal microflora in patients with seborrheic dermatitis]. Dermatovenereology. Cosmetology. Sexopathology 2016;1-4:246-51. Ukrainian.

Odintsova IV, Dyudyun AD, Gladyshev VV, Polion NM. [Seborrheic dermatitis і Malassezia spp]. Dermatology and Venereology 2019;3:31-33. Ukrainian. doi: https://doi.org/10.33743/2308-1066-2019-3-31-33

Olisova OYu. [Pathogenesis and treatment of seborrheic dermatitis]. Dermatovenereology and dermato¬cosmetology. 2016;1-2:38-42. Russian. Available from: https://www.umedp.ru/upload/iblock/97c/kelual.pdf.

Solodovnik SA, Gladyshev VV, Dyudyun AD, Lisyanskaya AP. [Preparation of ointments for rapid absorption of piroctone olamine with speech in the mind of a pharmacy. Information sheet]. 2019;210. Kyiv. Russian.

Sanders MGH, Pardo LM, Ginger RS, Kiefte-de Jong JC, Nijsten T. Association between diet and sebor¬rheic dermatitis: A cross-sectional study. J Invest Dermatol. 2019;139:108-14. doi: https://doi.org/10.1016/j.jid.2018.07.027

Clark GW, Pope SM, Jaboori KA. Diagnosis and treatment of seborrheic dermatitis. Am Fam Physician. 2015;91:185-90. Available from: https://www.aafp.org/afp/2015/0201/p185.html

De Souza Leao Kamamoto C, Sanudo A, Has¬sun KM, Bagatin E. Low dose oral isotretinoin for moderate to severe seborrhea and Seborrheic dermatitis: a randomized comparative. trial. Int J Dermatol 2017;56:80-85. doi: https://doi.org/10.1111/ijd.13408

Mameri ACA, Carneiro S, Mameri LMA, Telles da Cunha JM, Ramos-E-Silva M. History of seborrheic dermatitis: conceptual and clinico-pathologic evolution. Skinmed. 2017;15:187-94.

Karakadze MA, Hirt PA, Wikramanayake TC. The genetic basis of seborrheic dermatitis: a review. J Eur Acad Dermatol Venereol. 2018;32:529-36. doi: https://doi.org/10.1111/jdv.14704

Moreno-Vázquez K, Calderón L, Bonifaz A Dermatitis seborreica. Actualización Dermatol Rev Mex. 2020;64(1):39-49. Available from: https://www.medi¬graphic.com/pdfs/derrevmex/rmd-2020/rmd201f.pdf.

Downloads

Published

2021-03-26

How to Cite

1.
Odintsova I, Diudiun A. The use of extemporal dosage form with pyroctone olamine in the complex treatment of patients with seborrheic dermatitis. Med. perspekt. [Internet]. 2021Mar.26 [cited 2022May18];26(1):191-6. Available from: http://journals.uran.ua/index.php/2307-0404/article/view/228005

Issue

Section

CLINICAL MEDICINE

Most read articles by the same author(s)