Magnetic force microscopy of atherosclerotic plaque.

Authors

  • T. A. Alexeeva
  • S. V. Gorobets
  • O. Yu. Gorobets
  • I. V. Demianenko
  • O. M. Lazarenko

DOI:

https://doi.org/10.26641/2307-0404.2014.1.23707

Keywords:

atherosclerotic plaque, magnetic force microscopy, biogenic magnetite, magnetic phase

Abstract

In this work by methods of scanning probe microscopy, namely by atomic force microscopy and magnetic force microscopy the fragments of atherosclerotic plaque section of different nature were investigated. The fragments of atherosclerotic vessels with elements of immature plaque were taken during the coiled artery bypass surgery by alloprosthesis. As the result of investigation we found magnetically ordered phase of endogenous origin in the fragment of solid plaque of mixed structure. This phase is presents biogenic magnetic nanoparticles and their clusters with average size characteristic of 200-400 nm.

Author Biographies

T. A. Alexeeva

Institute of metallophysics named after G.V. Kurdumov NAS of Ukraine 2Academic Vernadsky str., 36, Kiev, 03680, Ukraine

S. V. Gorobets

National technical institute of Ukraine “Kiev polytechnic institute” 1,
Pobedy str., 37, Kiev, 03056, Ukraine

O. Yu. Gorobets

National technical institute of Ukraine “Kiev polytechnic institute” 1,
Pobedy str., 37, Kiev, 03056, Ukraine

I. V. Demianenko

National technical institute of Ukraine “Kiev polytechnic institute” 1,
Pobedy str., 37, Kiev, 03056, Ukraine

O. M. Lazarenko

State Scientific Institution “Scientific-Practical Centre of Preventive and Clinical Medicine” 3
Verchnya str., 5, Kiev, 01133, Ukraine

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Gorobets SV, Gorobets OYu, Demianenko IV. Self-organization of magnetite nanoparticles in providing Saccharamyces cerevisiaе yeasts with magnetic pro¬perties. // Journal of Magnetism and Magnetic Materials. 2013:53–57.

Grassi-Schultheiss PP, Heller F, Dobson J. Ana¬lysis of magnetic material in the human heart, spleen and liver. BioMetals. 1997;10:351–5.

Subha V Raman, Marshall W Winner III, Tam Tran. In Vivo MRI Atherosclerotic Plaque Cha¬rac¬terization Using Magnetic Susceptibility Distinguishes Symptom-Producing Plaques. JACC Cardiovasc Imaging. 2008;1:49–57.

Franchini M, Targher G, Montagnana M, Lippi G. Iron and thrombosis. Ann Hematol. 2008;87:167–73.

Ahluwalia N, Genoux A, Ferrieres J, Perret B, Carayol M, Drouet L, Ruidavets J-B. Iron Status Is As¬sociated with Carotid Atherosclerotic Plaques in Middle-Aged Adults. J. Nutr. 2010;140:812–6.

Stadler K, Bonini MG, Dallas S, Jiang JJ, Mason RP, Kadiiska MB. Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes. Free Radic Biol Med. 2008;45:866–74.

Kirschvink JL. Ferromagnetic crystals (mag¬netite?) in human tissue. J Exp Biol. 1981;92:333–5.

Kobayashi A, Yamamoto N, Kirschvink J. Stu¬dies of Inorganic Crystals in Biological Tissue: Magnetite in Human Tumor. Reprinted from Journal of the Japan Society of Powder and Powder Metallurgy. 1997;44:94.

Brem F, Hirt AM, Winklhofer M, Frei K, Yone¬kawa Y, Wieser H-G, Dobson J. Magnetic iron com¬pounds in the human brain: a comparison of tumor and hippocampus tissue. JR. Soc. Interface. 2006;3:833–41.

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Published

2014-03-24

How to Cite

1.
Alexeeva TA, Gorobets SV, Gorobets OY, Demianenko IV, Lazarenko OM. Magnetic force microscopy of atherosclerotic plaque. Med. perspekt. [Internet]. 2014Mar.24 [cited 2024Apr.26];19(1):4-10. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/23707

Issue

Vol. 19 No. 1 (2014)

Section

THEORETICAL MEDICINE

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