Biophysical parameters of the oral fluid and cells of the buccal epithelium in children with diseases of the thyroid gland in the course of orthodontic treatment of maxillodental anomalies.

Authors

  • K. A. Kolesnik
  • E. M. Denga

DOI:

https://doi.org/10.26641/2307-0404.2014.1.24702

Keywords:

orthodontic treatment, endocrine disturbances, complex prophylaxis

Abstract

The thyroid status disturbance may be reflected on the biological processes which underlie orthodontic tooth movement. Aim of research – to study state of the oral fluid and buccal epithelium cells (BEC) in the course of a complex orthodontic treatment of children with thyroid gland diseases. In 79 children with a diffuse nontoxic goiter (DNG) of the I-III degrees, stability of oral fluid pH (ΔpH), rate of mobile nuclei of BEC, ratio of electrophoretic displacement range of nuclei and plasmolemms was estimated. Estimation of corresponding parameters in the initial state, in 1, 3, 6 and 8 months after fixation of the fixed orthodontic apparatus was carried out. Children of the basic group according to pathology degree in addition received a prophylactic complex including preparations: “Vitrum Perfomens", "Teraflex", "Kalcicor", «Potassium iodide», «Echinacea compositum C», "Lizodent", "Osteobios". Ap­plication of the prophylactic complex in orthodontic treatment of children with DNG prevented growth of ΔрН after fixation of brackets. Throughout all time of supervision it promoted reduction of this rate which slightly exceeded average rate for the given age of children in 8 months. Application of this prophylactic complex already in 1 month after fixation of brackets has raised quantity of mobile BEC nuclei by 44% and by 1,64 times has increased the relation of ranges of plasmolemms and nuclei displacement. In 8 months of supervision percent of mobile nuclei BEC and the relation of Apl/Aya in the basic group was by 2 times more, than in a comparison group, approaching to average rate. Сhildren with thyroid gland diseases need active treatment-and-prophylactic measures at stages of active apparatus treatment. The developed therapeutic complexes of orthodontic treatment of maxillo-dental anomalies in children with DNG allows to effectively support and improve functional reactions in the organism and in the oral cavity, compensating stressful action of fixed orthodontic apparatuses.

Author Biographies

K. A. Kolesnik

SE «Crimean state medical university named after S. I. Georgievsky»
department of children's stomatology
Lenina boul., 5/7, Simferopol, 95006, Ukraine

E. M. Denga

SE «The Institute of Dentistry of the NAMS of Ukraine»
Rishelyevskaya str., 11, Odessa, 65000, Ukraine

References

Гублер Е.В. Применение непараметрических критериев статистики в медико-биологических исследованиях / Е.В. Гублер, А.А. Генкин. – Л., 1973. –73 c.

Деньга О.В. Адаптогенная профилактика и лечение основных стоматологических заболеваний у детей: автореф. дис. на соискание учен. степени д-ра мед. наук: спец. 14.01.22 «Стоматология» / О.В. Деньга.  К., 2001.  36с.

Деньга О.В. Метод оценки поверхностного заряда плазматических мембран клеток буккального эпителия у детей / О.В. Деньга // Вісник стоматології.  1997.  № 3.  С. 449-451.

Казимирко В.К. Остеопороз как биологическая проблема /В.К. Казимирко, В. И. Мальцев // Здоров’я України. – 2005. – № 21 (130). – С. 27-29.

Пат. № 47093, Україна. МПК (2009) G01N 33/487, u2009 09524. Спосіб прогнозування стоматологічних захворювань / О.В. Дєньга, Е.М. Дєньга, А.Е. Дєньга; опубл. 11.01.10; Бюл. № 1.– 4 с.

Шахбазов В.Г. Новый метод определения биологического возраста человека / В.Г. Шахбазов, Т.В. Колупаева, А. Л. Набоков // Лаб. дело.–1986.–№ 7.–С.404-406.

Carlos Fabue L. Dental management of patients with endocrine disorders / L. Carlos Fabue, Y. Jiménez Soriano, MG. Sarrión Pérez // J. Clin. Exp. Dent. – 2010. – Vol. 2, N 4. – P. 196-203.

Influence of sex hormone disturbances on the internal structure of the mandible in newborn mice / T. Fujita, J. Ohtani, M. Shigekawa [et al] // Eur. J. Orthod. – 2006. – Vol. 28, N 2. – P. 190-194.

Kerimov E.E. The metabolic and structural changes in periodontal tissue in patients with hypothyroidism / Е.Е. Kerimov, R.S. Binnatov // Georgian Med. News. – 2009. – Vol. 177. – P. 23-27.

Verna C. Tissue reaction to orthodontic tooth movement in different bone turnover conditions / C. Verna, B. Melsen // Orthod. Craniofac Res. – 2003. – Vol. 6, N 3. – Р. 155-163.

Zhang YL. Mechanical stimulus alters conformation of type 1 parathyroid hormone receptor in bone cells / Y.L. Zhang, J.A. Frangos, M. Chachisvilis // Am. J. Physiol. Cell Physiol. – 2009. – Vol. 296, N 6. – Р. 1391-1399.

Gubler EV, Genkin АА. [The use of nonparametric statistics criteria in biomedical research]. L. 1973:73. Russian.

Denga OV. [Adaptogenic prevention and treatment of major dental diseases in children: autoabs. diss. doc. med. sciences, specialty 14.01.22 "Dentistry"]. Kiev. 2001:36. Russian.

Denga OV. [Evaluation method of surface charge of the plasma membrane of buccal epithelium cells in children]. Vesnik stomatologії. 1997;3:449-51. Russian.

Kazimirko VK, Maltsev V. [Osteoporosis as biological problem]. Zdorov’ja Ukrai'ny. 2005;21(130):27-29. Russian.

Denga OV, Denga EM, Denga AE. [Method of predicting dental diseases. Patent number 47093, Ukraine. IPC (2009) G01N 33/487, u2009 09,524., publ. 11.01.10. 2010;1:4. Ukrainian.

Shakhbazov VG, Kolupaeva TV, Nabokov AL. [New method of determining biological age of the individual]. Laboratory delo. 1986;7:404-6. Russian.

Carlos Fabue L, Jiménez Soriano Y, Sarrión Pérez MG. Dental management of patients with endocrine disorders. J. Clin. Exp. Dent. 2010;2(4):196-203.

Fujita T, Ohtani J, Shigekawa M. Influence of sex hormone disturbances on the internal structure of the man¬dible in newborn mice. Eur. J. Orthod. 2006;28,(2):190-4.

Kerimov EE, Binnatov RS. The metabolic and structural changes in periodontal tissue in patients with hypothyroidism. Georgian Med. News 2009;177:23-27.

Verna C, Melsen B. Tissue reaction to orthodontic tooth movement in different bone turnover conditions. Orthod Craniofac Res. 2003;6(3):155-63.

Zhang YL, Frangos JA, Chachisvilis M. Mechanical stimulus alters conformation of type 1 parathyroid hormone receptor in bone cells. Am J. Physiol. Cell Physiol. 2009;296(6):1391-9.

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Published

2014-03-24

How to Cite

1.
Kolesnik KA, Denga EM. Biophysical parameters of the oral fluid and cells of the buccal epithelium in children with diseases of the thyroid gland in the course of orthodontic treatment of maxillodental anomalies. Med. perspekt. [Internet]. 2014Mar.24 [cited 2024Apr.26];19(1):96-101. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/24702

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CLINICAL MEDICINE