Study of the seasonal dynamics tendencies of sales of substitution therapy medications for dry-eye syndrome treatment in Ukraine

Yu.O. Tomashevska; O.V.  Kryvoviaz; O.V.  Makarenko; V.M.  Koval

doi:10.26641/2307-0404.2022.2.260389

Authors

Yu.O. Tomashevska National Pirogov Memorial Medical University, Vinnytsya, Pyrohov str., 56, Vinnytsia, 21018, Ukraine https://orcid.org/0000-0001-9708-1887
O.V. Kryvoviaz National Pirogov Memorial Medical University, Vinnytsya, Pyrohov str., 56, Vinnytsia, 21018, Ukraine https://orcid.org/0000-0001-5441-1903
O.V. Makarenko Dnipro State Medical University, V. Vernadsky str., 9, Dnipro, 49044, Ukraine https://orcid.org/0000-0001-8730-1081
V.M. Koval National Pirogov Memorial Medical University, Vinnytsya, Pyrohov str., 56, Vinnytsia, 21018, Ukraine https://orcid.org/0000-0001-9324-209X

DOI:

https://doi.org/10.26641/2307-0404.2022.2.260389

Keywords:

dry eye syndrome, substitution therapy medications, seasonal variations, retail

Abstract

The purpose of the article was to study the seasonality of retail sales of substitution therapy medications for dry eye syndrome treatment over the period of five years (2016-2020) in comparison with the annual monthly variations, taking into consideration the probable atypy of the 2020 indices due to the influence of the pandemic. To achieve the stated goal, retrospective, structural and graphic methods were used; a marketing analysis of the national pharmaceutical market from the point of presence of substitution therapy medications for dry eye syndrome was conducted. The next stage was the identification of seasonal variations in the time series of sales of the medications for treatment of conditions accompanied by the dry eye syndrome in Ukraine over the period of 2016-2020. The analysis of retail sales of substitution therapy medications for dry eye syndrome treatment over the period of 2016-2020 indicates a steady presence of seasonal peaks in March, August and December. The information received in the course of the study is necessary both for the patients and the employees of pharmaceutical companies engaged in wholesale and retail sales of medicines and medical devices. In terms of the patients, there a possibility to use preventative measures in order to limit the influence of a number of studied aggressive factors. And on the Based on the indexes of the seasonal demand for dry eye syndrome substitution therapy medications, pharmaceutical enterprises will be able to form the corresponding stock of the necessary medications thus ensuring the exists actual availability of substitution therapy medications for the population. This will indirectly but positively impact the treatment of patients with dry eye syndrome.

References

Govorukha VB, Tkachova OK. [Mathematical methods and forecasting models in the field of foreign economic activity]. Questions of applied mathematics and mathematical modeling. 2017;17:54-61. doi: https://doi.org/10.15421/321706

[State Register of Medicines of Ukraine]. State Expert Center of the Ministry of Health of Ukraine [Internet]. 2019 [cited 2021 June 12]. Ukrainian. Available from: http://www.drlz.com.ua/ibp/ddsite.nsf/all/shlist?opendocument

[State Register of Medical Equipment and Me-dical Devices]. Normative base [Internet]. 2019 [cited 2021 June 12]. Ukrainian. Available from: https://mozdocs.kiev.ua/medvyrob.php

[Medicines Reference Compendium]. Compendium – medicines [Internet]. 2019 [cited 2021 June 12]. Ukrainian. Available from: https://compendium.com.ua/uk

[Dry eye syndrome. Evidence-based clinical guidance]. State Expert Center of the Ministry of Health of Ukraine [Internet]. 2019 [cited 2021 June 12]. Uk¬rai-nian. Available from: https://www.dec.gov.ua/wp-content/uploads/2019/11/2019_10_02_kn_syndrom_soka.pdf

Ayaki M, Kawashima M, Uchino M, Tsubota R, Negishi K. Possible association between subtypes of dry eye disease and seasonal variation. Clin Ophthalmol. 2017;11:1769-75. doi: https://doi.org/10.2147/OPTH.S148650

Bron AJ, dePaiva CS, Chauhan SK, Bonini S, Gabison EE, Jain S, et al. TFOS DEWS II pathophyiology report. Ocul. Surf. 2017;15:438-510. doi: https://doi.org/10.1016/j.jtos.2017.05.011

Craig JP, Nichols KK, Akpek EK, Caffery B, Dua HS, Joo CK, et al. TFOS DEWS II definition and classification report. Ocul. Surf. 2017;15:276-83. doi: https://doi.org/10.1016/j.jtos.2017.05.008

Gomes JAP, Azar DT, Baudouin C, et al. TFOS DEWS II iatrogenic report. Ocul Surf. 2017;15(3):511-38. doi: https://doi.org/10.1016/j.jtos.2017.05.004

Hwang SH, Choi YH, Paik HJ, Wee WR, Kim MK, Kim DH. Potential Importance of Ozone in the Association Between Outdoor Air Pollution and Dry Eye Disease in South Korea. JAMA Ophthalmol. 2016;134(5):503-10. doi: https://doi.org/10.1001/jamaophthalmol.2016.0139

Jones L, Downie LE, Korb D, Benitez-del-Castil-lo JM, Dana R, Deng SX, et al. TFOS DEWS II mana-gement and therapy report. Ocul. Surf. 2017;15:575-628. doi: https://doi.org/10.1016/j.jtos.2017.05.006

Kumar N, Feuer W, Lanza NL, Galor A. Seasonal Variation in Dry Eye. Ophthalmology. 2015;122(8):1727-9. doi: https://doi.org/10.1016/j.ophtha.2015.02.013

Pharmxplorer. Proxima Research [Internet]. 2012. Available from: http://www.pharmxplorer.com.ua. [cited 2020 Oct 01].

Watts N, Adger WN, Agnolucci P, et al. Health and climate change: policy responses to protect public health. Lancet. 2015;386(10006):1861-914. doi: https://doi.org/10.1016/S0140-6736(15)60854-6