Systemic correction of osteoporosis of the alveolar processes of the jaw in complex treatment of patients with generalized periodontitis
Keywords:melatonin, vitamin D, generalized periodontitis, alveolar process
Generalized periodontitis is accompanied by progressive bone atrophy of the alveolar process of the jaws. The first signs of osteoporosis appear in the alveolar process already in the early stages. Complex treatment of generalized periodontitis includes, first of all, an etiopathogenetic approach. The object of the study is to investigate the effectiveness of biotherapeutic correction of osteoporosis of the alveolar processes of the jaws in the complex treatment of patients with generalized periodontitis adding melatonin and vitamin D. The study involved 121 patients aged from 26-40 years with generalized periodontitis of initial-I and I stages with a chronic course, and 45 apparently healthy volunteers from the control group. All patients gave voluntary informed consent to participate in the study. Groups of patients were randomized approximately by same age and gender. Before onset of treatment and 6 months after the complex treatment the level of vitamin D and melatonin level was measured and examined for osteoporosis using a cone-beam computed tomography. In order to give a qualitative and quantitative assessment of the state of mineralization of the spongy and compact bone tissue of the alveolar processes of the jaws histographic analysis of computed tomography was used. 55 patients in addition to traditional local treatment were added vitamin D intake of 4000 IU/d with meals and melatonin intake of 1.5 mg at bedtime for 1 month. It was stated, that level of melatonin in saliva is inversely proportional to the level of vitamin D in the blood serum in patients with generalized periodontitis and patients from the group with clinically healthy periodontium. Using melatonin and vitamin D in the complex of treatment of patients with generalized periodontitis leads to an increase X-ray density of bone tissue of the alveolar processes of the jaws, which allows to achieve restoration of bone density of alveolar processes and longer stabilization of dystrophic – inflammatory process in the periodontium. To strengthen the bone tissue of the alveolar processes of the jaws in patients with generalized periodontitis, it is advisable to use melatonin and vitamin D in a complex treatment.
Antomonov MYu. [Mathematical processing and analysis of biomedical data]. Kyiv: Medynform; 2018. ISBN 978-966-409-202-6.
Amrein K, Scherkl M, Hoffmann M. Vitamin D deficiency 2.0: an update on the current status worldwide. Eur J Clin Nutr. 2020;74:1498-513. doi: https://doi.org/10.1038/s41430-020-0558-y
Balaji TM, Vasanthi HR, Rao SR. Gingival, Plasma and Salivary Levels of Melatonin in Periodontally Healthy Individuals and Chronic Periodontitis Patients: A Pilot Study. Journal of Clinical and Diagnostic Research. 2015;9(3):ZC23. doi: https://doi.org/10.7860/JCDR/2015/11311.5652
Balaji TM, Varadarajan S, Jagannathan R, Mahendra J, Fageeh HI, Fageeh HN, et al. Melatonin as a Topical/Systemic Formulation for the Management of Periodontitis: A Systematic Review. Materials (Basel). 2021;14(9):2417. doi: https://doi.org/10.3390/ma14092417
Borysenko AV. Periodontal and Oral Mucosa Diseases. In 2 volumes. Kyiv: AUS Medicine Publishing; 2018. p. 224-253.
Cashman KD. Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing. Calcif Tissue Int. 2020;106:14-2. doi: https://doi.org/10.1007/s00223-019-00559-4
Ferlazzo N, Andolina G, Cannata A, Costanzo MG, Rizzo V, Currò M, et al. Is Melatonin the Cor-nucopia of the 21st Century? Antioxidants (Basel). 2020;9(11):1088. doi: https://doi.org/10.3390/antiox9111088
Ghallab NA, Hamdy E, Shaker OG. Malondial-dehyde, superoxide dismutase and melatonin levels in gingival crevicular fluid of aggressive and chronic periodontitis patients. Australian Dental Journal. 2016;61(1):53-61. doi: https://doi.org/10.1111/adj.12294
Hassan RS, Salman SA. Evaluation of salivary mela¬tonin and periodontal parameters in type II diabetic patients with chronic periodontitis: A comparative study. Indian J of Public Health Research and Development. 2019;10(10):2740-5. doi: https://doi.org/10.5958/0976-5506.2019.03283.2
Konečná B, Chobodová P, Janko J, Baňasová L, Bábíčková J, Celec P, Tóthová Ľ. The Effect of Melatonin on Periodontitis. Int J Mol Sci. 2021;22(5):2390. doi: https://doi.org/10.3390/ijms22052390
Lodhi K, Saimbi CS, Khan MA, Nath C, Shu-kla R. Evaluation of melatonin levels in saliva in gingivitis and periodontitis cases: A pilot study. Contemp Clin Dent. 2016;7(4):519-23. doi: https://doi.org/10.4103/0976-237X.194115
Permuy M, López-Peña M, González-Cantalapiedra A, Muñoz F. Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases. Int J Mol Sci. 2017 Apr 19;18(4):865. PMID: 28422058; PMCID: PMC5412446. doi: https://doi.org/10.3390/ijms18040865
Ramesh A, Prakash A, Thomas B, Shetty M. Salivary melatonin and total antioxidant capacity in repro-ductive and postmenopausal women. Journal of the International Clinical Dental Research Organization. 2016;8(1):39. doi: https://doi.org/10.4103/2231-0754.176249
Sharan K, Lewis K, Furukawa T, Yadav VK. Regulation of bone mass through pineal-derived melatonin-MT2 receptor pathway. J. Pineal Res. 2017;4:63. doi: https://doi.org/10.1111/jpi.12423
Shariq N, Zohaib K, Sana Z, Muhammad S. Therapeutic potential of melatonin in oral medicine and periodontology. The Kaohsiung Journal of Medical Sciences. 2016;32(8):391-6. doi: https://doi.org/10.1016/j.kjms.2016.06.005
Ternovoy NK, Drobotun OV, Kolotilov NN. Polymorbidity and heterogeneity of intact bone tissue in patients with malignant and metastatic bone tumors. Radiation Diagnostics, Radiation Therapy. 2019;3:25-29. doi: https://doi.org/10.37336/2707-0700-2019-3-3
How to Cite
Copyright (c) 2023 Medicni perspektivi
This work is licensed under a Creative Commons Attribution 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.