The rate of liver impairment, character of bacteremia and serum bactericidal activity in patients with cirrhosis.

Authors

  • S. N. Krutikov
  • Yu. L. Krivorutchenko
  • O. N. Postnikova
  • M. S. Krutikova
  • T. A. Logadir

DOI:

https://doi.org/10.26641/2307-0404.2014.2.28319

Keywords:

liver cirrhosis, liver impairment, bacteremia, serum bactericidal activity

Abstract

Dependence of prevalence and severity of bacteremia on the rate of liver impairment, serum bactericidal activity (SBA), and serum concentrations of C-reactive protein (CRP) and granulocyte colony-stimulating factor (G-CSF) in 80 hospitalized patients with liver cirrhosis (LC) have been studied. It was shown that risk factors associated with the development of bacteremia are high by Child-Pugh score and low SBA, CRP and G-CSF levels. Patients with LC, class A had the highest SBA, CRP and G-CSF levels. Still 14,3% of them developed less severe bacteremia associated with one type of microorganisms isolated from blood. Patients with LC, class B had intermediate SBA, CRP and G-CSF levels. They developed severe bacteremia in 52,6% of cases and less severe bacteremia – in 21,1% of cases. Patients with LC, class C had low SBA, CRP and G-CSF levels. They developed severe bacteremia in 62,5% of cases and less severe bacteremia – in 25% of cases.

Author Biographies

S. N. Krutikov

SI «Crimean State Medical University named after S.I. Georgievsky»
Ministry of Public Health Ukraine,
Lenin boulevard, 5/7, Simferopol, 95006, Crimea, Ukraine,

Yu. L. Krivorutchenko

SI «Crimean State Medical University named after S.I. Georgievsky»
Ministry of Public Health Ukraine,
Lenin boulevard, 5/7, Simferopol, 95006, Crimea, Ukraine,

O. N. Postnikova

SI «Crimean State Medical University named after S.I. Georgievsky»
Ministry of Public Health Ukraine,
Lenin boulevard, 5/7, Simferopol, 95006, Crimea, Ukraine,

M. S. Krutikova

SI «Crimean State Medical University named after S.I. Georgievsky»
Ministry of Public Health Ukraine,
Lenin boulevard, 5/7, Simferopol, 95006, Crimea, Ukraine,

T. A. Logadir

SI «Crimean State Medical University named after S.I. Georgievsky»
Ministry of Public Health Ukraine,
Lenin boulevard, 5/7, Simferopol, 95006, Crimea, Ukraine,

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Published

2014-06-18

How to Cite

1.
Krutikov SN, Krivorutchenko YL, Postnikova ON, Krutikova MS, Logadir TA. The rate of liver impairment, character of bacteremia and serum bactericidal activity in patients with cirrhosis. Med. perspekt. [Internet]. 2014Jun.18 [cited 2024Mar.29];19(2):39-45. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/28319

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Section

CLINICAL MEDICINE