Translocation of trace elements in the system "Mother-placenta-fetus" in rats with physiological pregnancy and under conditions of lead exposure.

Authors

  • E. M. Biletska
  • N. М. Onul

DOI:

https://doi.org/10.26641/2307-0404.2014.3.28504

Keywords:

lead, transplacental migration, trace elements, influence, embryogenesis

Abstract

Heavy metals are the second major environmental pollutants. Especially toxic is lead, increased content of which in the body of a pregnant determines the development of pregnancy, childbirth and postpartum period complications and is potentiated by deficiency of essential trace elements - zinc and copper. Article presents the results of impact of  solutions of lead acetate and citrate in experimental models. Solutions of metals were injected into the stomach through a tube once a day during 19 days of pregnancy in the dose of 0,05 mg/kg in the form of inorganic compound - lead acetate and in organic form – lead citrate. The content of trace elements - lead, cadmium, copper and zinc were determined by stripping voltamperometry. In addition, indices of placental and fetal accumulation, as well as index of transplacental migration were calculated. Effect of lead during pregnancy in all biosubstrates is increased by 1,3-1,9 times as compared with the control group. This causes imbalance of essential trace elements due to significant reduction in zinc content in all the studied biological substrates. Prolonged contact with lead during pregnancy leads to disruption of placenta, inability of the placenta to fully protect the fetus from excessive intranatal influence of xenobiotics.

Author Biographies

E. M. Biletska

SE "Dnipropetrovsk medical academy of Health Ministry of Ukraine"
Department of General Hygiene
Oktyabrskaya sq., 4, Dnipropetrovsk, 49027, Ukraine

N. М. Onul

SE "Dnipropetrovsk medical academy of Health Ministry of Ukraine"
Department of General Hygiene
Oktyabrskaya sq., 4, Dnipropetrovsk, 49027, Ukraine

References

Антомонов М.Ю. Математическая обработка и анализ медико-биологических данных / М.Ю. Анто¬монов. - К.: Фірма малого друку, 2006. - 558 с.

Білецька Е.М. Вплив свинцю у макроформі і у вигляді цитрату, отриманого за нанотехнологією, на перебіг вагітності та антенатальний розвиток щурів / Е.М.Білецька, Н.М.Онул // Медицина сьогодні і завтра. -2013. - №2 (59).- С. 5-9.

Гельфонд Н.Е. Обмен макро- и микро¬элемен¬тов при введении свинца и в условиях сорбционной коррекции на фоне беременности / Н.Е.Гельфонд, Е.В. Старкова, В.В. Груф // Медицина и образование в Си¬бири. – 2014. - №2.

Индивидуальная биокоррекция экологозави¬симых состояний у критических групп населения / Белецкая Э.Н., Онул Н.М., Главацкая В.И. [и др.] // Гигиена и санитария. – 2014. - №2. – С. 34-37.

Никитин А.И. Вредные факторы среды и ре¬про¬дуктивная система человека (ответственность пе¬ред будущими поколениями) / А.И.Никитин. – Санкт-Петербург: ЭЛБИ-СПб, 2005. – 216 с.

Онул Н.М. Експериментальна оцінка ембріо¬ток¬сичності свинцю як фактору малої інтенсивності / Н.М.Онул // Таврич. медико-биол. вестник. – 2013. - Т. 16, № 1, ч.1 (61). – С.165-168.

Ткаченко Т.А. Кислотно-лужний стан крові ва¬гітних щурів за введення їм ацетату свинцю / Т.А.Ткаченко // Укр. біохім. журн. – 2008. – Т.80, №5. – С. 112-116.

Трахтенберг І.М. Профілактична токсикологія та медична екологія / І.М.Трахтенберг. – К.: Авіцена, 2011. – 120 с.

Тяжелые металлы внешней среды и их влияние на репродуктивную функцию женщин / А.М. Сер¬дюк, Э.Н. Белицкая, Н.М. Паранько, Г.Г. Шмат¬ков. – Днепропетровск: АРТ-ПРЕСС, 2004. – 148 с.

Aisha, M. Fahim. Effect of dietary calcium on maternal and fetal lead toxicity and teratogenecity in rats / Aisha M. Fahim; Samya El-M. Salama, K.H. Koratem // Egypt. J. Comp. Path. & Clinic. Path. – 2008. – Vol. 21 N. 4. – Р. 283 – 305.

European convention for the protection of verte¬brate animals used for experimental and other scien¬ti¬fic purposes. – Strasburg: Council of Europe, 1986. – 53 p.

Antomonov MYu. [Mathematical processing and analysis of medical and biological data]. Kyiv: Fіrma malogo druku; 2006. Russian.

Bіletska EM, Onul NM. [Influence of on preg¬nancy and antenatal development of rats leadin the macroform and as citrate, obtained by nanotechnology]. Meditsina sogodnі і zavtra. 2013;2(59):5-9.Ukrainian.

Gelfond NE, Starkova EV, Gruf VV. [Exchange of macro- and microelements in the conditions of lead intro¬duction and sorption correction on pregnancy back¬ground]. Meditsina i obrazovanie v Sibiri. 2014;2. Russian.

Beletskaya EN, Onul NM, Glavatskaya VI, An¬tonovа EV, Golovkova TA. [Individual biocorrection of the ecological depended states in the critical groups of population]. Gigiena i sanitariya. 2014;2:34-7. Russian.

Nikitin AI. [Harmful factors of environment and reproductive system of man (responsibility before future generations)]. St. Petersburg: ELBI-SPb; 2005.

Onul NM. [Experimental estimation of lead em¬briotoxity as a factor of low intensity]. Tavricheskiy mediko-biologicheskiy vestnik. 2013;1(61):165-8. Ukrainian.

Tkachenko TA. [Acid and alkaline state of preg¬nant rats’ blood under influence of lead acetate]. Ukrainskiy biokhimicheskiy zhurnal. 2008;80(5):112-6. Ukrainian.

Trahtenberg IM. [Preventive toxicology and me¬dical ecology]. Avicena; 2011. Ukrainian.

Serdyuk AM, Beletskaya EN, Paranko NM, Shmat¬kov GG. [Heavy metals of the environment and their impact on the reproductive function of women]. Dnepropetrovsk: ART-PRESS; 2004. Russian.

Aisha, Fahim M, Samya, Salama El-M, Koratem KH. Effect of dietary calcium on maternal and fetal lead toxicity and teratogenecity in rats. Egypt. J. Comp. Path. & Clinic. Path. 2008;21(4):283-305.

European convention for the protection of verte¬brate animals used for experimental and other scientific purposes. Council of Europe, Strasburg; 1986.

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Published

2014-09-30

How to Cite

1.
Biletska EM, Onul NМ. Translocation of trace elements in the system "Mother-placenta-fetus" in rats with physiological pregnancy and under conditions of lead exposure. Med. perspekt. [Internet]. 2014Sep.30 [cited 2024Mar.29];19(3):04-9. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/28504

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Section

THEORETICAL MEDICINE