DOI: https://doi.org/10.26641/2307-0404.2016.2.72282

Modern aspects of atibiotic sensitivity of prominent pathogens of infectious complications.

O. A. Nazarchuk, N. I. Osadchuk, D. V. Palij

Abstract


In the research antibiotic sensitivity of opportunistic pathogens was studied. In 2011-2015 from 405 patients with burns there were isolated clinical strains of S. aureus (n 130), P. aeruginosa (n 127), A. baumannii (n 176), being the prominent pathogens of infectious complications. Clinical strains of S. aureus, P. aeruginosa, A. baumannii obtained all morphological, tentorial, cultural and biochemical qualities, typical for these species of bacteria. On the basis of the received results there wascarried out approximation and interpolation of these data, dynamic prognostic indexes of changes in S. aureus, P. aeruginosa, A. baumannii antibiotic sensitivity were obtained. Low sensitivity to ampicillini/sulbactam (58,63±8,58%), ceftriaxone (55,75±14,24%), gentamicin (57,92±10,76%), tobramycin (64,67±10,3%)  in clinical strains of S. аureus was proved. Prognostic optimizations of S. аureus sensitivity to amoxicillini/clavulanat (82,35%), gatifloxacin (94,12%) were determined. Clinical strains of P. aeruginosa, A. baumannii were shown to have low sensitivity to ceftazidime, cefoperazone, cefoperazone/sulbactam(20,08±2,98%; 48,88±6,49%, respectively). Progressive decrease of sensitivity to amikacin in P. aeruginosa (29,77±7,55%), A. baumannii (17,0±1,34 %) and to gatifloxacin in P. aeruginosa (28,53±1,35%), isolated from patients with burns were determined.


Keywords


infectious complications; antibiotics; sensitivity; burns

Full Text:

PDF

References


Necrasova LS, Svita VM, Glushcevich TG, et al. [The study of sensitivity of microorganisms to antibacte-rials: methodical recommendations МВ 9.9.5-143]. Kyiv. 2007;74. Ukrainian.

Volodars'kiy ET, Kosheeva LO. [Statistical data analysis: text-book]. Kyiv: NAU. 2008;308. Ukrainian.

Potemkin VG. [The system of engineering and scientific calculations МАТLАБ 5.х: [In 2 editions] ]. Moscow: DIALOG-VIFI; 1999. Ed. 1. 366 p. 1999. Ed. 2. 1999; 304. Russian.

Yunkerov VI, Grigor'ev SG, Rezvantsev MV. [Mathematical and statistical data analysis]. Saint-Petersburg. 2011;318. Russian.

Leclercq R, Canton R, Brown DF, et al. EUCAST expert rules in antimicrobial susceptibility testing. Cli¬nical Microbiology Infection. 2013;19(2):141-160.

Paliy G, Nazarchuk O, Osadchuk N, Paliy D, Ko-valenko I. Prognostic criteria of sensitivity to antibiotics of Staphylococcus clinical strains J Education, Health and Sport (formerly Journal of Health Sciences). 2015;5(7):26-33.

Rice LB. The clinical consequences of antimicro-bial resistance. Current Opinion in Microbiology. 2009;12(5):476-81.


GOST Style Citations






 

This work is licensed under a Creative Commons Attribution 4.0 International License