Function of external respiration in patients after kidney transplantation under conditions of immunosuppressive therapy.
DOI:
https://doi.org/10.26641/2307-0404.2018.1(part1).127245Keywords:
function of external respiration, kidney transplantation, immunosuppressive therapy, cyclosporine, tacrolimusAbstract
The aim of our study was to evaluate the changes in the parameters of the function of external respiration in patients after kidney transplantation due to chronic kidney disease and to assess the relationship between the level of cyclosporin A and tacrolimus in the blood with FVD indices. The study included 37 patients after kidney transplantation. The first group included 27 patients who received cyclosporine at an average dose of 225 [175-350] mg/day under the immunosuppressive therapy regimen, the second group included 10 patients who received tacrolimus at an average dose of 8.25 [5.0-9.0] mg/day. A significant difference (p˂0.05) between the indicators of the VCmax (78 [71-90]% and 76.5 [72-78]%), FVC (93 [85-99]% and 95 [91-98]%), PEF (82 [64-94]% and 80 [69-84]%), MEF25-75 (75 [66-112]% and 82.5 [67-90]%) was found in patients of the first and second groups relative to the FVD of the comparison group: VCmax (102.5 [98-113]%), FVC (107.5 [105.5-124]%), PEF (99.5 [95-102.5]%), MEF25-75 (98.5 [97.5-101.5]%). In both groups, a statistically significant negative correlation between the indicators of the VCmax, FVC and the level of cyclosporin A (R=-0.69, p<0.0001 and R=-0.4, p<0.037) in the blood in the first group and FVC and tacrolimus (R=-0.72, p<0.018) in the second group was found. A moderate decrease in the VCmax values in patients after kidney transplantation requires monitoring of the function of external respiration and managing such patients by nephrologists together with specialists in the pulmonological profile.
References
Goreyov VA, Kaabak MM, Babenko NN. [Influence of the protocol of induction immunosuppressive therapy on the state of the allotransplanted kidney]. Transplantologiya. 2017;1(9);7-11. Russian.
Kuryata OV, Cherkasova AV. [Arterial hypertension in chronic kidney disease]. Dnipropetrovsk, Gerda. 2014;79. Russian.
Kuryata OV, Frolova EO. [Lipid metabolism and cardiovascular risk in patients with chronic kidney disease]. Dnіpropetrovsk, «Gerda». 2013;111. Ukrainian.
Pertseva TO, Kіreeva TV, Shtepa OO. [The influence of comorbid pathology on expressiveness of inflammantory process in patients with lower respiratory tract infections]. Zaporozhye medical journal. 2015;4(91):21-25. Ukrainian.
Pertseva TO, Kіreeva TV, Shtepa OO. [The effectiveness and necessity of carrying out ethiological diagnostics in patients with liwer respiratory tract infections]. Problemi ekologії ta meditsini. 2014;18(1-2):17-25. Ukrainian.
Pertseva TA, Konopkina LI. [Fundamentals of the study of the ventilation function of the lungs: clinical and diagnostic value. Methodical manual for doctors and students of medical schools].Dnepropetrovsk, «Art-Press». 2008;66. Russian.
Gabriel M Danovich. [Transplantation of the kidney]. Moysyuka YaG. editor. Moskva «GEOTAR- Media». 2013;845. Russian.
Canet E, Osman D, Lambert V, et al. Acute respiratory failure in kidney ransplant recipients: a multicenter study. Critical Care. 2011;15(91):2-10.
Cury JL, Brunetto AF, Aydon RD. Negative effects of chronic kidney failure on lung function and functional capacity. Rev Bras Fisioter. 2010;14 (2):91-98.
Pencheva V, Petrova D, Genov D, Georgiev O. Pulmonary Complications as a Cause of Death after Renal Transplantation. Open Journal of Internal Medicine 2014;4:41-46.
Kupeli E, Ulubay G, Colak T, et al. Pulmonary Complications in Renal Recipients after Transplantation. Transplantation Proceedings. 2011;43:551-3.
Canadian Organ Replacement Register. 2011 report. Ottawa: Canadian Institute for Health Information; 2013.
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