Development of technology for manufacture of cream with wild carrot seeds lipophilic extract for burn wounds treatment
DOI:
https://doi.org/10.15587/2313-8416.2016.62872Keywords:
cream, burn wounds, Wild carrot seeds lipophilic extract, herbal remedy, composition, technologyAbstract
Aim. The aim of our research was to substantiate and to develop the optimal composition and technology for manufacture of the soft dosage form as a combined wound healing and anti-inflammatory cream with Wild carrot seeds lipophilic extract applied for burn wounds treatment.
Methods. Pharmaco-technological, physical, chemical, microscopic, and structural and mechanical methods of research have been used.
Results. According to the results, the ointment base type – the 1st type emulsion base, – as well as its optimal composition: butylhydroxytoluene – 0,02, Euxyl РЕ 9010 – 0,500, creambase № 6,00, cetylstearyl alcohol – 3,00, corn oil – 15,00, purified water – to 100,00 have been determined. Colloid stability and thermo stability, organoleptic and physico-chemical properties have been studied. As a result of research the main active ingredient concentration of the remedy – Wild carrot seeds lipophilic extract – has been selected: 5%.
All active ingredients were administered to the drug gradually. The results of structural and mechanical research have shown the influence of the active ingredients on rheological parameters of the remedy.
By microscopic research an optimal speed and time for homogenization of the cream with Wild carrot seeds lipophilic extract have been substantiated – 5000 rpm during 10 minutes.
On the grounds of physico-chemical research the optimal technology for manufacture of cream, providing maintenance of specific temperature, procedure for administration of the ingredients of the remedy, as well as mixing conditions and cooling dynamics, has been substantiated and to developed.
Conclusion. The optimal composition and technology for manufacture of the soft dosage form as a combined wound healing and anti-inflammatory cream with Wild carrot seeds lipophilic extract applied for burn wounds treatment, and manufacturing technology scheme have been theoretically and experimentally substantiated; stepwise procedure for the quality control of cream with Wild carrot seeds lipophilic extract has been carried out
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