Main theoretical, pathophysiological and practical aspects of neuroplasticity.

Authors

  • А. V. Pogorelov
  • Yu. V. Bukreyeva
  • О. А. Gavva
  • V. І. Pashkovsky
  • О. М. Tolubayev
  • Е. К. Dukhovenko

DOI:

https://doi.org/10.26641/2307-0404.2017.1.100856

Keywords:

neuroplasticity, neurogenesis, neuroretina, synapse, adaptation, sprouting, synapse transmission, functions recovery

Abstract

Results of the state-of-the-art review of the "neuroplasticity" term development and new data about the sanogenetic, pathophysiological, neurophysiological, bio - and neurochemical bases of the nervous system recovery processes are given in this article. Key mechanisms of adaptive, desadaptive, responsive and cross modal forms of neuroplasticity within primary and secondary neuroplasticity are distinguished. The specific character of neurogenesis and functional reorganization of neuronets in specific regulatory structures of the brain in the norm and pathogenesis are outlined. Controversies about functional and morphological aspects of neuroplastic processes are presented. Application-oriented methods of neuroplasticity study are considered and systemically classified. Clinical diagnostics with the specified neu­rovisualization, neurochemical, neurophysiological criteria and coefficients is considered also. Specific methods of neurorehabilitation and perspective urgent directions of neuro- sanogenesis are designated using physical, reflex, neuropsychological, behavioural brain stimulation methods and pharmacological therapy.

Author Biographies

А. V. Pogorelov

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of neurology and ophthalmology
Dzerzhinsky str., 9, Dnipro, 49044, Ukraine

Yu. V. Bukreyeva

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of neurology and ophthalmology
Dzerzhinsky str., 9, Dnipro, 49044, Ukraine

О. А. Gavva

«Dnipropetrovsk Regional Clinical Hospital named after I.I. Mechnikov»*
Soborna square, 14, Dnipro, 49005, Ukraine

V. І. Pashkovsky

«Dnipropetrovsk Regional Clinical Hospital named after I.I. Mechnikov»*
Soborna square, 14, Dnipro, 49005, Ukraine

О. М. Tolubayev

«Dnipropetrovsk Regional Clinical Hospital named after I.I. Mechnikov»*
Soborna square, 14, Dnipro, 49005, Ukraine

Е. К. Dukhovenko

«Dnipropetrovsk Regional Clinical Hospital named after I.I. Mechnikov»*
Soborna square, 14, Dnipro, 49005, Ukraine

References

Bogolepova AN. [Problem of neuroplasticity in neurology]. Zhurn. nevrologii i psihiatrii. 2010;8:62-65. Russian.

Dzjak LA.[Neuroplasticity and vestibular dys­function]. International neurologic journal. 2006;6(10). Ukrainian.

Semchenko VV. [Synaptic activity of the brain (fundamental and applied aspects)].Moscow: Direkt – media. 2014;499. Russian.

Chollet F. Pharmacologic approaches to cerebral aging and neuroplasticity : insights from the stroke model. Dialogues Clin. Neurosci. 2013;15(1):67-76.

Theriot JJ, et al. Cortical sensory plasticity in a model of migraine with aura. J. Neurosci. 2012;32(44):54-61.

DieterichDC, Kreutz MR. Proteomics of the Synapse – A Quantitative Approach to Neuronal Plas­ticity. Mol. Cell Proteomics. 2016;15(2):368-81.

Dietz V. Neuronal plasticity after a human spinal cord injury: positive and negative effects. Exp Neurol. 2012;235(1):110-5.

Kirsty L, et al. Dynamics of Hippocampal Neuro­genesis in Adult Humans. Cell. 2013;153(6):1219-27.

Froemke RC. Plasticity of cortical excitatory – in­hibitory balance. Annu. Rev. Neurosci. 2015;38:195-219.

Griesbach GS, Hovda DA. Cellular and molecular neuronal plasticity. Handb Clin Neurol. 2015;128:681-90.

Mori F, et al. Growth factors and synaptic plasticity in relapsing – remitting multiple sclerosis. Neuromolecular Med. 2014;16(2):490-8.

Hegde A.N. Proteolysis, synaptic plasticity and memory. Neurobiol Learn Mem. 2016;7:11-8.

Hübener M., Bonhoeffer T. Neuronal plasticity : beyond the critical period. Cell. 2014;159(4):727-37.

Delpech JC, et al. Microglia in neuronal plastici­ty: Influence of stress. Neuropharmacology. 2015;96:19-28.

Maguire EA, et al. Navigation – related structural change in the hippocampi of taxi drivers. Proc. Natl. Acad Sci U S A. 2000;97(8):4398-40.

Khan F. et al. Neurorehabilitation : applied neuro­plasticity. J. Neurol. 2016;24:1-13.

Li P, et al. Neuroplasticity as a function of second language learning : anatomical changes in the human brain. Cortex. 2014;58:301-24.

Gustin SM, et al. Pain and plasticity: is chronic pain always associated with somatosensory cortex activity and reorganization? J. Neurosci. 2012;32(43):74-84.

Stogsdill JA, Eroglu C, Stogsdill JA. The inter­play between neurons and glia in synapse development and plasticity. Curr Opin Neurobiol. 2016;42:1-8.

Wefelmeyer W, Puhl CJ, Burrone J. Homeo­static Plasticity of Subcellular Neuronal Structures : From Inputs to Outputs. Trends Neurosci. 2016;39(10):656-67.

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Published

2017-04-04

How to Cite

1.
Pogorelov АV, Bukreyeva YV, Gavva ОА, Pashkovsky VІ, Tolubayev ОМ, Dukhovenko ЕК. Main theoretical, pathophysiological and practical aspects of neuroplasticity. Med. perspekt. [Internet]. 2017Apr.4 [cited 2024Nov.20];22(1):4-9. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/100856

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Section

THEORETICAL MEDICINE