Phytotherapeutic drugs with nephroprotective activity (review).


  • E. A. Podpletnyaia
  • N. V. Khomiak
  • E. V. Sokolova
  • S. P. Kaydash
  • E. V. Khomiak



phytotherapy, nephroprotection, anti-inflammatories, diuretics, nephropathy, urolithiasis, herbal urolitholytics, lyophilized powder of watermelon (LPW)


The article analyzes characteristics of chemical composition and pharmacodynamics of phytotherapeutic agents (monopreparations and complexes), used in the treatment of kidney and urinary tract diseases. Analysis of main pharmacological effects of medicinal plants and their complexes was made, comparative characteristics of herbal remedies by indications for use in acute and chronic diseases of the kidneys and urinary tract (pyelonephritis, cystitis, urethritis, glomerulonephritis, nephrolithiasis) and edematous syndrome of various etiologies was carried out. Pharmacological characteristics of diuretic, nephroprotective and nephrolitholytic action of watermelon lyophilized powder according to its composition (flavonoids, macro- and micronutrients, vitamins and so on.) was analyzed. On the basis of data on a wide range of biological activity, sufficient clinical efficacy as adjuvant therapy drugs, as well as good tolerability of herbal remedies, appropriateness and prospects of search for new plant nephroprotective drugs was concluded.

Author Biographies

E. A. Podpletnyaia

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of General and Clinical Pharmacy

N. V. Khomiak

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of General and Clinical Pharmacy

E. V. Sokolova

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of General and Clinical Pharmacy

S. P. Kaydash

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of General and Clinical Pharmacy

E. V. Khomiak

Department of Pharmacology and Clinical Pharmacology *
Dzerzhinsky str., 9, Dnipro, 49044, Ukraine


1. Alyaev YuG, Rudenko VI, Filosofova EV. [Mo­dern aspects of medical treatment of patients with uro­lithiasis]. RMZh. 2006;2:18-22. Russian.

2. Boyko A I, Gubar' AA. [Experience of using a combination of phytotherapy in patients with uretero­lithiasis]. Pochki. 2013;1:63-66. Russian.

3. Valyagina-Malyutina ET. [Drug plants]. SPb.: Spets. Lit; 1996;340. Russian.

4. Vinogradova TA, Gazhev BN, Vinogradov VM, Martynov VK. [Practical phytotherapy]. M.: EKSMO-Press; SPb.: Valeri SPD, 2001;640. Russian.

5. Belogolovskaya EG, Oreshchenko AV, Durnev AD. [Effect of beta-carotene and aspartame in the clasto­genic activity of cyclophosphamide and dioxyidin in mice]. Byulleten' eksperimental'noy biologii i meditsiny. 2000;130(11):570-573. Russian.

6. Grodzins'kiy AM. [Medicinal plants: Encyclo­pedia directory]. URE, 1990;44. Ukrainian.

7. Dіkal MV. [Features of morphological changes in chronic glomerulonephritis Mazuhi, as a prerequisite for the development of chronic kidney disease]. Klіnіchna anato­mіya ta operativna khіrurgіya. 2014;13(2):58-92. Ukrainian.

8. Tovchiga OV, Sinitsa VO, Shtrigol' SY., Schorna NS. [Ground elder extract reduces gentamicin nephro­toxicity in rats]. Zaporozhskiy meditsinskiy zhurnal. 2008;2:36-40. Ukrainian.

9. Kapitanov AB, Pimenov AM. [Carotenoids as an­tioxidant modulators of cellular metabolism]. Uspekhi sovremennoy biologii. 1996;116(2):183-6. Russian.

10. Kukes VG, Starodubtsev AК, [Clinical pharma­cology and pharmacotherapy: a textbook. - 3rd edition]. 2012;840. Russian.

11. Pirog LA. [Clinical Nephrology]. Kyev: Zdo­rov'ya, 2004;153-87. Ukrainian.

12. Kovalenko VN, Viktorov АР. [Compendium - 2016. Medications]. Morion, 2016;2270. Russian.

13. Ladygina EA, Morozova RS. [Phytotherapy. 4th edition revised and supplemented]. Meditsina, 1990;346. Russian.

14. Lebedev AA. [Kidney Pharmacology. Essays on the 50 anniversary of the problems of research]. Samara, 2002;103. Russian.

15. Grodzins'kiy AM. [Herbs: encyclopedic guide]. URE, 1990;544. Ukrainian.

16. Mikhaylov IV. [Modern drugs from medicinal plants: a guide]. Astrel, 2003;240. Russian.

17. Monatko KV. [Experimental study of nephropro­tective action of Action Freeze watermelon pulp powder: Abstract of dissertation for the degree of candidate of pharmaceutical sciences, specialty 14.03.05]. Kharkіv, 2014;20. Ukrainian.

18. Nesen AO. [Pathogenetic mechanisms and diag­nostic-therapeutic strategy of combining atherosclerosis and chronic kidney disease: Abstract of dissertation of the candidate of medical sciences]. Kharkіv, 2013;39. Ukrainian.

19. Putyrskiy IV, ProkhorovNN. [Universal Encyclo­pedia of Medicinal Plants]. Knizhnyy dom Makhaon, 2000;656. Russian.

20. Rossikhin VV, Khoshchenko YuA. [The results of applying herbal preparation Urohol in patients with urolithiasis complicated by chronic calculous pyelo­nephritis]. MedicusAmicus, 2009;2:30-31. Russian.

21. Samoylenko VN. [Kidney diseases. The modern view on the treatment and prevention]. Sankt-Peterburg: IG "Ves'", 2008;244. Russian.

22. Samylinoy IA, Severtseva VA. [Medicinal plants of the state pharmacopoeia]. ANMI, 1999;490. Russian.

23. Sokolov SYa. [Phytotherapy and phytopharma­cology: a guide for physicians]. Meditsinskoe infor­matsionnoe agentstvo, 2000;580. Russian.

24. Solomenchuk TM, Semegen-Bodak KhV. [As­sessment of the prevalence of risk factors for coronary heart disease depending on the stage of chronic heart disease in women]. Zaporozhskiy meditsinskiy zhurnal. 2012;5:63-66. Ukrainian.

25. Tovchiga OV, Shtrygol' SYu, Koyro OO. [Medi­cinal plants and renal excretory function]. Bukovins'kiy medichniy vіsnik. 2012;3(63):29-31. Russian.

26. Tovchiga OV, Koyro OО, Shtrygol' SYu. [Urohol - a new solution in the pharmacotherapy of renal disease and biliary tract]. Provizor. 2011;18:42-45. Russian.

27. Kraydashenkо OV, Kupnovits'kа ІG. [Pharmaco­therapy (textbook for students of pharmaceutical facul­ties). A second edition]. Vіnnitsya: Nova kniga, 2013;646. Ukrainian.

28. Khomenko VS, Khomenko NR. [Medicinal plants in veterinary medicine and traditional practices: Direc­tory]. Kyev: Urozhay, 1993;168. Ukrainian.

29. Pirіg LA, Іvanov DD, Taran OІ. [Chronic renal failure]. Avrora-plus, 2004;96. Ukrainian.

30. Chistik T. [Efficacy and safety of herbs in di­seases of the urinary system]. Journal “Pochki”. 2013;1:35-40. Russian.

31. Shilo VYu, Khasabov NN. [Anemia in chronic ki­dney disease]. Lechashchiy vrach. 2008;1:52-54. Russian.

32. Yagodka VS, Skripkin YuK. [Medicinal plants in dermatology and cosmetology]. Kyev. Nauk. Dumka, 1991;272. Russian.

33. Duke JA, Ayensu ES. Medicinal plants of China. Algonac, Michigan: Reference Publ, 1985;705.

34. Chiej R. Encyclopaedia of medicinal plants. Edin­burgh: MacDonald, 1984;448.

35. Pietruck F, Kuhlmann MK, Lange B, Feldkamp T, Herget-Rosenthal S. Effect of quercetin on hypoxic injury in freshly isolated rat proximal tubules. J Lab Clin Med. 2003;142(2):106-12.

36. Yuksel Y, Yuksel R, Yagmurca M, Haltas H, Er­damar H, Toktas М. Effects of quercetin on methotrexate-induced nephrotoxicity in rats. Hum Exp Toxicol. 2016;22.

37. Nordfors L, Luttropp K, Carrero J. Genetic stu­dies in chronic kidney disease: Basic concepts. J Nephrol. 2012;25(2):141-9.

38. Klahr S, Morrissey J. L-arginine as a therapeutic tool in kidney disease. Semin Nephrol. 2004;24(4):389-94.

39. Lai Q, Wei J, Mahmoodurrahman M, Zhang C, Quan S, Li T. Pharmacokinetic and nephroprotective be­nefits of using Schisandra chinensis extracts in a cyclo­sporine A-based immune-suppressive regime. Drug Des Devel Ther. 2015;8:4997-5018.

40. Chiang SS, Tai CW, Chung CJ, Shiue HS, Chen JB, Su CT. Micronutrients and lifestyles in Taiwanese patients with stage 3 to 5 chronic kidney disease. Nutri­tion. 2010;26(3):276-82.

41. Park J Y, Lee D, Jang H J. Protective Effect of Artemisia asiatica Extract and Its Active Compound Eupatilin against Cisplatin-Induced Renal Damage. Evid Based Complement Alternat Med. 2015;4:83-86.

42. Jeong EK, Jang HJ, Kim SS. Protective effect of eupatilin against renal ischemia-reperfusion injury in mi­ce. Transplant Proc. 2015;47(3):757-62.

43. Hosseini F, Naseri MK, Badavi M. Protective effect of beta-carotene pretreatment on renal ischemia / reperfusion injury in rat. Pak J Biol Sci. 2009;12(16):1140-5.

44. Qi L, Cao C, Hu L, Chen S, Zhao X, Sun C. Me­tabonomic analysis of the protective effect of quercetin on the toxicity induced by mixture of organophosphate pesticides in rat urine. Hum Exp Toxicol.; 2016.

45. Hu QH, Zhang X, Wang X. Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice. Eur J Nutr. 2012;51(5):593-606.

46. Singh D, Chander V, Chopra K. The effect of quercetin, a bioflavonoid on ischemia / reperfusion in­duced renal injury in rats. Arch Med Res. 2004;35(6):484-94.

47. Ugur S, Ulu R, Dogukan A. The renoprotective effect of curcumin in cisplatin-induced nephrotoxicity. Ren Fail. 2015;37(2):332-6.

48. Wang ZS, Xiong F, Xie XH, Chen D, Pan JH, Cheng L. Astragaloside IV attenuates proteinuria in strep­tozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress. B M C Nephrol. 2015;3:44-46.




How to Cite

Podpletnyaia EA, Khomiak NV, Sokolova EV, Kaydash SP, Khomiak EV. Phytotherapeutic drugs with nephroprotective activity (review). Med. perspekt. [Internet]. 2017Apr.4 [cited 2024Jul.24];22(1):10-9. Available from: