Phytotherapeutic drugs with nephroprotective activity (review).


  • E. A. Podpletnyaia
  • N. V. Khomiak
  • E. V. Sokolova
  • S. P. Kaydash
  • E. V. Khomiak



phytotherapy, nephroprotection, anti-inflammatories, diuretics, nephropathy, urolithiasis, herbal urolitholytics, lyophilized powder of watermelon (LPW)


The article analyzes characteristics of chemical composition and pharmacodynamics of phytotherapeutic agents (monopreparations and complexes), used in the treatment of kidney and urinary tract diseases. Analysis of main pharmacological effects of medicinal plants and their complexes was made, comparative characteristics of herbal remedies by indications for use in acute and chronic diseases of the kidneys and urinary tract (pyelonephritis, cystitis, urethritis, glomerulonephritis, nephrolithiasis) and edematous syndrome of various etiologies was carried out. Pharmacological characteristics of diuretic, nephroprotective and nephrolitholytic action of watermelon lyophilized powder according to its composition (flavonoids, macro- and micronutrients, vitamins and so on.) was analyzed. On the basis of data on a wide range of biological activity, sufficient clinical efficacy as adjuvant therapy drugs, as well as good tolerability of herbal remedies, appropriateness and prospects of search for new plant nephroprotective drugs was concluded.

Author Biographies

E. A. Podpletnyaia

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of General and Clinical Pharmacy

N. V. Khomiak

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of General and Clinical Pharmacy

E. V. Sokolova

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of General and Clinical Pharmacy

S. P. Kaydash

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of General and Clinical Pharmacy

E. V. Khomiak

Department of Pharmacology and Clinical Pharmacology *
Dzerzhinsky str., 9, Dnipro, 49044, Ukraine


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How to Cite

Podpletnyaia EA, Khomiak NV, Sokolova EV, Kaydash SP, Khomiak EV. Phytotherapeutic drugs with nephroprotective activity (review). Med. perspekt. [Internet]. 2017Apr.4 [cited 2024Jun.24];22(1):10-9. Available from: