Study of embryotoxic effects of intranasally administred desloratadine on laboratory animals.

Authors

  • Т. А. Alekhina
  • V. А. Turkina
  • О. І. Grushka

DOI:

https://doi.org/10.26641/2307-0404.2017.1.101437

Keywords:

embryotoxicity, intranasal administration, desloratadine

Abstract

The study was conducted to detect possible changes in embryogenesis and negative effects of third generation antihistamine – desloratadine – after intranasal administration of 1.3 mg/m3 and 13.0 mg/m3 of the substance to laboratory animals during their prenatal period. In these circumstances, desloratadine does not cause any significant changes of embryogenesis parameters. Macroscopic examination of the fetus and placenta in animals of experimental groups did not reveal any pathology or physiological deviations from the norm. 13.0 mg/m3 concentration of the drug caused a decrease in the weight of embryos in comparison with control group of animals and physiological data, despite a well developed, without visible pathology, placenta. This neces­sitates an in-depth study of possible teratogenic effects of intranasally administred desloratadine to laboratory animals.

Author Biographies

Т. А. Alekhina

Danylo Halytskiy Lviv National Medical University
Pekarska Str., 69, Lviv, 79010, Ukraine

V. А. Turkina

Danylo Halytskiy Lviv National Medical University
Pekarska Str., 69, Lviv, 79010, Ukraine

О. І. Grushka

Danylo Halytskiy Lviv National Medical University
Pekarska Str., 69, Lviv, 79010, Ukraine

References

Belousov YuB, Leonova MV. [Clinical pharma­cology of drugs during pregnancy, prenatal and postnatal periods]. Farmateka. 2002;6:22-27. Russian.

Glushhenko AV. [The analytical review of mo­dern antiallergic preparations]. Ukranskij Medychnyj al'manah. 2013;3:187-90. Russian.

Experimental study of embryotoxical action of drugs (guidelines)]. Кiev, 2000;40. Ukrainian.

Zambrzhitskiy ОN, Batsukova NL. [Occupational Health in pharmacy organizations and the pharmaceutical industry enterprises: a training handbook]. Minsk, BGMU, 2014;52. Russian.

Trakhtenberg IM, Sova RE, Sheftel' VO, Onikien­ko FA. [The rules in toxicology problem (modern con­cepts and methodological approaches, the basic pa­ra­meters and constants)]. Moskva, "Medicina", 1991;203. Russian.

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Published

2017-04-04

How to Cite

1.
Alekhina ТА, Turkina VА, Grushka ОІ. Study of embryotoxic effects of intranasally administred desloratadine on laboratory animals. Med. perspekt. [Internet]. 2017Apr.4 [cited 2024Jul.25];22(1):102-6. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/101437

Issue

Section

PREVENTIVE MEDICINE