Primary toxicological evaluation of nitroxoline on laboratory animals.

Authors

  • G. I. Yaskiv

DOI:

https://doi.org/10.26641/2307-0404.2017.1.101440

Keywords:

Nitroxoline, parameters of toxicity, skin-resorptive effect, locally irritating effect, cumulative activity

Abstract

Nitroxoline is an effective antibacterial agent that is industrially produced by chemical and pharmaceutical enterprises in Ukraine. Parameters of its toxicity are determined under conditions of acute and subchronic toxicological experiments on 3 kinds of laboratory animals, by administering the drug orally and by application onto the skin and mucous membranes. The duration of acute experiment was 14 days, subchronical - 24 days. It was found that median lethal dose (DL50) for white female rats is 980 (852:1127) mg/kg, of white male rats – 835 mg/kg, white male mice– 660 mg/kg, by this parameter the drug can be attributed to 3 class of hazard – moderately hazardous substance. Average effective time of death (ET50) for albino rats is 28 hours. Species sensitivity of laboratory animals to nitroxoline is slightly expressed. The death of the animals starts on the first day after the injection and is recorded during three days of the experiment. In application on intact skin, locally-irritant and skin-resorptive effects are absent. After contact with the mucous membrane of the eye the drug causes weak irritant effect. Nitroxoline has a moderate cumulative activity.

Author Biography

G. I. Yaskiv

Lviv national medical university of Danylo Halytskyу
Central research laboratory
Pekarska str, 69, Lviv, 79010, Ukraine

References

[Guidelines for the formulation of research to substantiate the health standards of harmful substances in the working area: Method. directions N 2163-80]. Moskva, 1980;20. Russian.

[Rationale for the maximum permissible con­centration of drugs in the air of the working area in the ambient air of places: Method. instructions N 544, 2005]. Kyiv, MOZ Ukrainsky, Kyiv, 2015;19. Ukrainian.

[Assessment of the impact of hazardous che­micals on the skin and justification of maximum per­missible levels of skin contamination: ME 2102-79].Moscow, 1980;23. Russian.

Lim RK, Rink KG, Glass HG, Soaje-Echa­gue EA. A method for the evaluation of cumulation and tolerance by the determination of acute and subchronic median effective doses. Arch. Intern. Pharm. 1961;130:336−52.

Bergogne-Berezin E1, Berthelot G, Muller-Se­rieys C. Pre­sent status of nitroxoline. Pathol Biol (Paris). 1987;35:873.

Maida A, Chrusаiеlska K. Medicine Pracy. 1965;XXX1V:321-96.

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Published

2017-04-04

How to Cite

1.
Yaskiv GI. Primary toxicological evaluation of nitroxoline on laboratory animals. Med. perspekt. [Internet]. 2017Apr.4 [cited 2024Jul.20];22(1):111-4. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/101440

Issue

Section

PREVENTIVE MEDICINE