Peculiarities of mental and behavioral disorders due to use of designer drugs among young population and problems of early diagnostics (literature review).


  • I. D. Spirina
  • S. V. Rokutov
  • E. S. Fedenko
  • A. V. Shornikov
  • O. E. Holopchenko



synthetic cannabinoids, spices, dependency, narcotization


The analysis of the data of the domestic and foreign literature regarding the dynamics of narcotization among children and adolescents is carried out. It has been established that at present the growth rates of the use of psychoactive substances by minors far outstrip those of the adult population. It is also determined that in most cases "adult" drug addiction is formed in a teenage environment and therefore adolescents are a group of high-risk narcotization. Besides, new types of additions are constantly added: non-opioid analgetics, antidepressants, pharmacy products based on medicinal plants with stimulating or sedative properties, new means of perfumery and household chemicals, volatile organic compounds, etc. In this regard, in the clinical picture of drug intoxication, new variations of affective, psycho-organic and psychosomatic effects and complications are noted. In recent years, synthetic cannabinoids has rapidly gained "popularity" among young people that are successfully promoted by marketers. They are the part of the so-called designer drugs, appearing in the markets in the form of bath salts, flavors, fertilizers for indoor plants and "smoking mixtures" - spices. The publications of domestic and foreign authors give a lot of evidence of the ability of these substances not only to cause a state of intoxication, alienation, relaxation, but also leads to dependence on them with severe consequences for the psyche and all organism as a whole. Thus, the powerful anthropogenic damaging effect of designer drugs demonstrates concrete signals of a threat to health, demography and the economy of the society as a result of their use by the population.

Author Biographies

I. D. Spirina

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Vernadsky str., 9, Dnipro, 49044, Ukraine

S. V. Rokutov

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Vernadsky str., 9, Dnipro, 49044, Ukraine

E. S. Fedenko

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Vernadsky str., 9, Dnipro, 49044, Ukraine

A. V. Shornikov

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Vernadsky str., 9, Dnipro, 49044, Ukraine

O. E. Holopchenko

CI «Dnipropetrovsk Clinical Psychiatric Hospital of Dnipropetrovsk Regional Counsil» *
Bekhterev str., 1, Dnipro, 49115, Ukraine


Golovko AI, Golovko SI, Leont'eva LV, Bari­nov VA, Basharin VA, Bonitenko EYu, et al. [The biolo­gical activity of the synthetic cannabinoids, first identified in illegal trafficking during the period of 2011-2013]. Narkologiya. 2013;(10):73-84. Russian.

Boyko OA, Panov SL. [Socio-psychological as­pects of "Spice" using]. Psikhopedagogika v pravookhra­nitel'nykh organakh. 2016;(1):41–3. Russian.

Halatsan OV, Shapovalov VV (mol ), Omel'chen­ko VO. [Development of organizational measures for the implementation of the concept of state policy in the sphere of counteracting of the drug addiction spread and illegal circulation of the psychoactive substances on the regional level on the principles of medical and pharma­ceutical law]. Ukrayins'kyy visnyk psykhonevrolohiyi. 2013;21(1):43–50. Ukrainian.

Grigoryan AZ. [Psychopathogenetic models of affective disorders in patients suffering from addictive pathology]. Ukrayins'kyy visnyk psykhonevrolohiyi. 2015;23(3):63–7. Russian.

Krivenkov AN, Anosova EV. Cannabinoid de­pendence syndrome on the pathologically altered soil in adolescents (case report). Narkologiya. 2013;(5):49–55. Russian.

Mendelevich VD. [Psychotic disorders due to drug use: current state of the problem]. Narkologiya. 2014;(7):93–100. Russian.

Golovko AI, Leont'eva LV, Basharin VA, Go­lovko SI, Ivanov MB, Bonitenko EYu, Barinov VA. [The biological activity of CB1 receptors allosteric modu­lators]. Narkologiya. 2014;(8):83–93. Russian.

Voloshyn PV, Lins'kyy IV, Minko OI, Samoylova OS, Lins'ka KI. [The population and genetic analysis of formation of addictive states and estimation of pos­sibilities for counteraction to their proliferation]. Ukrayin­s'kyy visnyk psykhonevrolohiyi. 2013;21(4):5-11. Ukrainian.

Khobzey MK, Kolyadkova OM, Zinchenko OM. [Mental and behavioral disorders due alcohol and other psychoactive substances using inUkraine. State drug careUkraine: Information-analytical review by the 1990-2010]. Kyyiv; Kharkiv: «Pleyada»; 2011. 138 p. Ukrainian.

Rozhanets VV. [Spice phenomenon]. Narko­logiya. 2010;(3):80–84. Russian.

Izotov BN, Savchuk SA, Grigor'ev AM, Me­l'nik AA, Nosyrev AE, Dzhurko YuA, Zabirova IG, Sur­kova LA, Listvina VP, Samoylik LV, Rozhanets VV. [Synthetic cannabinoids in herbal mixtures «spice». Identification of metabolites of jwh-018 as the markers of its use in biological fluids of rats and humans]. Narko­logiya. 2011;(2):73–84. Russian.

Sofronov GA, Golovko AI, Barinov VA, Ba­sharin VA, Bonitenko EYu, Ivanov MB. [Synthetic can­nabinoids. State of the problem]. Narkologiya. 2012;(10):97–110. Russian.

Klimenko TV, Kozlov AA, Istomina VV, Bes­palova LYu. [Socio-demographic and clinical cha­rac­teristics of people of draft age who abuse alcohol and drugs]. Narkologiya. 2013;(7):57–61. Russian.

Grigor'ev AM, Mel'nik AA, Savchuk SA,Simo­novAB, Izotov BN, Nosyrev AE, Rozhanets VV. [Chro­mate-mass-spectrometric identification of metabolites of synthetic cannabimimetics JWH-250 inhuman and rat biological fluids]. Narkologiya. 2012;(6):75–85. Russian.

Chernobrovkina TV, Ibragimova MV. [Clinical laboratory diagnostics of the medical and biological consequences of narcotization in children and adolescents in outpatient monitoring]. Kharkiv: «Pleyada»; 2010. 148 p. Russian.

Shapovalova VO, Shapovalov VV, Nehrets'kyy SM. [Organizational & legal and moral aspects of the drug addiction spread research (on example of the cannabis) in the modern society in a view of spiritual heritage of the orthodox church]. Ukrayins'kyy visnyk psykhonevrolohiyi. 2010;18(2):97–101. Ukrainian.

Vandrey R, Dunn KE, Fry JA, Girling ER. A sur­vey study to characterize use of Spice products (synthetic cannabinoids). Drug Alcohol Depend. 2012 Jan 1;120(1–3):238–41.

Castaneto MS, Gorelick DA, Desrosiers NA, Hartman RL, Pirard S, Huestis MA. Synthetic Canna­binoids: Epidemiology, Pharmacodynamics, and Clinical Implications. Drug Alcohol Depend. 2014:1(144):12–41.

Mack AH, Brady KT, Miller SI, Frances RJ. Clinical Textbook of Addictive Disorders.New York;London:GuilfordPublications. 2015;753.

Cooper ZD. Adverse Effects of Synthetic Canna­binoids: Management of Acute Toxicity and Withdrawal. Curr Psychiatry Rep. 2016;18(5):52.

Davis C, Boddington D. Teenage cardiac arrest following abuse of synthetic cannabis. Heart Lung Circ. 2015;24(10):e162-3.

Jinwala FN, Gupta M. Synthetic cannabis and respiratory depression. J Child Adolesc Psychopharmacol. 2012;22(6):459-62.

Musah RA, Domin MA, Walling MA, Shepard JRE. Rapid identification of synthetic cannabinoids in herbal samples via direct analysis in real time mass spectrometry. Rapid Commun Mass Spectrom. 2012;26(9):1109–14.

Kasper AM, Ridpath AD, Arnold JK, Chatham-Stephens K, Morrison M, Olayinka O, Parker C, Galli R, Cox R, Preacely N, Anderson J, Kyle PB, Gerona R, Martin C, Schier J, Wolkin A, Dobbs T. Severe Illness Associated with Reported Use of Synthetic Cannabinoids - Mississippi, April 2015. MMWR Morb Mortal Wkly Rep. 2015;64(39):1121–2.

Lapoint J, James LP, Moran CL, Nelson LS, Hof­fman RS, Moran JH. Severe toxicity following syn­thetic can­nabinoid ingestion. Clin Toxicol (Phila). 2011;49(8):760–4.

Sun X, Dey SK. Synthetic cannabinoids and po­tential reproductive consequences. Life Sci. 2014;97(1):72–7.

Galanter M, Kleber HD, Brady K, editors. The American Psychiatric Publishing textbook of substance abuse treatment. Fifth edition.Washington,DC: Ame­rican Psychiatric Publishing. 2015;960.

Nacca N, Vatti D, Sullivan R, Sud P, Su M, Mar­raffa J. The Synthetic Cannabinoid Withdrawal Synd­rome. Journal of Addiction Medicine. 2013;7(4):296–8.

WinstockAR, Barratt MJ. Synthetic cannabis: a comparison of patterns of use and effect profile with natural cannabis in a large global sample. Drug Alcohol Depend. 2013;131(1–2):106–11.




How to Cite

Spirina ID, Rokutov SV, Fedenko ES, Shornikov AV, Holopchenko OE. Peculiarities of mental and behavioral disorders due to use of designer drugs among young population and problems of early diagnostics (literature review). Med. perspekt. [Internet]. 2017Jun.29 [cited 2023Dec.1];22(2):14-20. Available from: