Mechanism of formation of oxalate concrements in the presence of ureaseproducing pathogens in urine (conception).

Authors

  • S. A. Vozianov
  • D. V. Koval
  • A. V. Rudenko
  • N. I. Zheltovska

DOI:

https://doi.org/10.26641/2307-0404.2017.2.109829

Keywords:

nephrolithiasis, urease-producing microorganisms, mineral composition of concrements, mechanism of lithogenesis

Abstract

The aim of the study was to as­certain the role of U.urealyticum in formation of phosphates and oxalates in kidneys and factors promoting this pro­cess. The work represents the author’s conception of this process. There were fully examined 79 patients with nephro­lithiasis with the aim to determine the species difference of pathogenic agents of the accompanying inflammatory process and there was compared the chemical structure of the removed concrements. There was stated the role of the urease-producing bacteria (P.mirabilis and U.urealyticum) in the process of phosphate and oxalate lithogenesis and the accompanying factors, which initiate these reactions (urinary pH, endogenic urease, index of oxalic acid concentration). The work presents the comparative analysis of lithogenesis in the presence of accompanying bacteria of different taxonomic position. The authors’ conception of the role of U.urealyticum and P.mirabilis in lithogenesis has been elaborated.

Author Biographies

S. A. Vozianov

SE «Institute of urology of AcademyІ of medical sciences of Ukraine»
Ju. Kocjubins'kogo st., 9-A, Kyiv, 04053, Ukraine

D. V. Koval

Cherkasy Regional Hospital Cherkasy Regional Council
Mendeleev st., 3, Cherkasy, 18009, Ukraine

A. V. Rudenko

SE «Institute of urology of AcademyІ of medical sciences of Ukraine»
Ju. Kocjubins'kogo st., 9-A, Kyiv, 04053, Ukraine

N. I. Zheltovska

SE «Institute of urology of AcademyІ of medical sciences of Ukraine»
Ju. Kocjubins'kogo st., 9-A, Kyiv, 04053, Ukraine

References

1. Bazarnova MA. [Clinical Laboratory Diagnos­tics]. Kyiv: High School, 1994;415. Ukrainian.

2. Vainberg ZS. [Kidney stones]. Moscow: Medici­ne, 1971;183. Russian.

3. Vozianov SA, Koval DV, Rudenko AV, Zheltov­sky NI. [Defining processes depending kidney stone for­mation in the biological properties found in urine conditional - pathogenic microorganisms]. Urology. 2016;20(4):8-14. Ukrainian.

4. Kamyshnikov VS. [Clinical Laboratory tests from A to Z and their diagnostic Profiles]. Handbook. Minsk: Belaruss science, 1999;415-22. Russian.

5. Lyulko OO, Barannik SI. [The chemical compo­sition and structural features of staghorn nephrolithiasis]. Urology. 2009;2:5-10. Ukrainian.

6. Chukhlovin AB, Emanuel YuV, Napalkova OV, Lan­da SB. [The role of local infection in the genesis of urolithiasis]. Nephrology. 2011;15(3):11-7. Russian.

7. Sivorinovsky GA. [To the Methods of quan­titative determination of oxalic acid in urine]. Labora­tornoe delo. 1969;7:401-5. Russian.

8. Asplin JR, Favus MJ, Coe FL. Nephrolithiasis. In: Brenner and Rector's the kidney (5th ed.) Philadelphia: Saunders, 1996;1893-935.

9. Brown TR. On the relation between the variety of microorganisms and the composition of stone in Cal­culous Pyelonephritis. JAMA. 2001;36:1394-97.

10. Kramer G, Klingler HC, Steiner GE. Role of bacteria in the development of kidney stones. Curr. Opin. Urol. 2000;10:35-8.

11. Parmar MS. Kidney stones. British Medical J. 2004;328:1420-24.

12. Coker C, Poore CA, Xin L, Mobley HT. Patho­genesis of Proteus mirabilis urinary tract infection. Microbes Infect. 2000;2:1497-505.

13. Rahman NU, Meng MV, Stoller ML. Infections and urinary stone disease. Curr. Pharm Des. 2003;9:975-81.

14. Rodman JS. Struvite stones. Nephron. 1999;81:50-9.

15. Torzewska A, Staczek P, Rozalski A. Crystal­lization of urine mineral components may depend on the chemical nature of Proteus endotoxin polysaccharides. J. Med. Microbiol. 2003;52:471-7.

Downloads

Published

2017-06-29

How to Cite

1.
Vozianov SA, Koval DV, Rudenko AV, Zheltovska NI. Mechanism of formation of oxalate concrements in the presence of ureaseproducing pathogens in urine (conception). Med. perspekt. [Internet]. 2017Jun.29 [cited 2024Jul.15];22(2):60-6. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/109829

Issue

Section

CLINICAL MEDICINE