Clinical, general, hemocoagulation and pathologicanatomical features of patients with moderate and severe community acquired pneumonia by the data of retrospective analysis.

Authors

  • T. A. Pertseva
  • T. V. Kireyeva
  • K. O. Bielosludtseva
  • M. A. Kryhtіna

DOI:

https://doi.org/10.26641/2307-0404.2017.3.111858

Keywords:

community acquired pneumonia, complications, thrombosis

Abstract

According to literature data,patients with community acquired pneumonia (CAP) fall into several groups of unfavorable prognostic factors. Development of thrombotic complications is one of causes of mortality of hospitalized patients. In this case systemic inflammation, which is always present inmoderate and severe CAP, is the starting mechanism of formation of disorders in the hemostasis system. The aim of our work was to determine anamnestic, clinical, laboratory and pathologic anatomical features in patients with CAP, taking into account markers of systemic inflammation and coagulogram indices, as well as predicting the occurrence of complications. In the course of the work, a retrospective analysis of 151 medical histories of hospitalized patients with CAP was made. We analyzed anthropometric indicators, complaints at the time of hospitalization, results of physical examination, results of the chest X-ray, clinical and laboratory indicators, microbiological sputum analysis and to assess the possibility of thrombotic complications a RAM scale was used. It was found that late asking for medical help, the presence of mixed infection, underestimation of the severity of condition and severe systemic inflammation increase the risk of lethal outcome in patients with CAP. Considering a high risk of thrombosis in patients with CAP, it is necessary to assess the risk of thrombotic complications with the help of special scales, as well as timely detection and correction of disorders from the hemostasis system.

Author Biographies

T. A. Pertseva

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of internal medicine 1
V.Vernadsky str., 9, Dnipro, 49044, Ukraine

T. V. Kireyeva

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of internal medicine 1
V.Vernadsky str., 9, Dnipro, 49044, Ukraine

K. O. Bielosludtseva

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of internal medicine 1
V.Vernadsky str., 9, Dnipro, 49044, Ukraine

M. A. Kryhtіna

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of internal medicine 1
V.Vernadsky str., 9, Dnipro, 49044, Ukraine

References

Dzyublyk AYa, Judyna LV [Basic principles of diagnosis and treatment of community-acquired pneumo­nia]. Zdorov"ya Ukrayiny. 2011;6:47-50. Ukrainian.

Lapach SN, Gubenko AV, Babych PN. [Statis­tical methods in biomedical research using Exel]. Moryon, 2000;320. Russian.

Feshchenko YuI, Holubovs'ka OA, Honcha­rov KA, Dzyublyk OYa. [Community acquired pneumo­nia in adults: etiology, pathogenesis, classification, diagnosis, antibiotic therapy (project of clinical gui­delines)]. Ukrayins'kyy pul'monolohichnyy zhurnal, 2012;4:5-17. Ukrainian.

Pertseva TO, Kireyeva TV, Bielosludtseva КO. [Retrospective analysis of lethal cases of severe hostile pneumonia: "Masks of Severe Pneumonia"]. Ukrayins'kyy pul'monolohichnyy zhurnal, 2013;2:26–30, Ukrainian.

Pertseva TO, Kiryeyeva TV, Bielosludtseva KO, Boltyans'kyy SV. [Severe virus-associated hospitalized pneumonia: predictors of lethality]. Zaporozhskyy me­dytsynskyy zhurnal, 2016;3(96):38–45. Ukrainian.

[Comparative data on the prevalence of respi­ratory diseases and medical care for patients with pulmonologic and allergic diseases inUkrainefor 2006-2012]. Natsional'na akademiya medychnykh nauk Ukrayiny. Tsentr medychnoyi statystyky Ukrayiny MOZ Ukrayiny, 2013;2-4. Ukrainian.

[About the approval of clinical protocols for the provision of medical care in the specialty "Pulmo­nology"]. Order N 128 MoH ofUkraine; 2007. Ukrainian.

Birnbaumer DM. SMART-COP: A Better Pneu­monia Stratification Score? Journal Watch Emer­gency Medicine. 2008;1:375.

Sachin Y, D'Angelo G, Mayr Fl, Kellum JA. Ele­vated Hemostasis Markers after Pneumonia Increases One-Year Risk of All-Cause and Cardiovascular Deaths The GenIMS Investigator Published; 2011.

Singanayagam A, Singanayagam A, Elder DHJ, Chalmers JD. Is community-acquired pneumonia an in­dependent risk factor for cardiovascular disease? Eur. resp. j. 2012;39(1):187-96.

Maris NA, De Vos AF, Bresser P. Activation of coagulation and inhibition of fibrinolysis in the lung after inhalation of lipopolysaccharide by healthy volunteers. Thromb. Haemost. 2005;93(1036):40.

Zakai N, Wright J, Cushman M. Risk factors for venous thromboembolism among hospitalized patients. Journal of Thrombosis and Haemostasis. 2004;2156-61.

Downloads

How to Cite

1.
Pertseva TA, Kireyeva TV, Bielosludtseva KO, Kryhtіna MA. Clinical, general, hemocoagulation and pathologicanatomical features of patients with moderate and severe community acquired pneumonia by the data of retrospective analysis. Med. perspekt. [Internet]. 2017Oct.12 [cited 2024Nov.22];22(3):17-24. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/111858

Issue

Section

CLINICAL MEDICINE