Forecasting of development of acute poisonings in agricultural workers while using combined formulations based on difenoconazole.
DOI:
https://doi.org/10.26641/2307-0404.2017.3.111938Keywords:
difenoconazole, combined formulations, acute poisoning, risk, action selectivityAbstract
In the general structure of occupational diseases, a large proportion belongs to acute poisoning with pesticides (mainly group cases). However, today it is impossible to drop the use of pesticides in agriculture. Their application ensures high biological and economic efficiency of the latter, reduces losses of the yield. The purpose of the work was to predict the possibility of acute toxic effects in agricultural workers when working with combined formulations based on difenoconazole. Materials and methods. To assess the influence on the organism of the workers of the above-mentioned substances and formulations on their basis, the coefficient of inhalation poisoning possibility (CIPP), the coefficient of selective action of the pesticide in inhalation effect (CSAing) and the selective action of the pesticide in the dermal effect (CSAderm) were calculated. Results. Calculated values of CSAing (103.4-4701.2) and CSAderm (237.4-12345.7) for all investigated active substances were more than 100, this indicates to a rather high selectivity of their action. By the CSAing value formulations Celeste Top, Celeste Trio, Dinali, Cydeli Top belong to pesticides with a relatively low selectivity of action when they are inhaled by workers in the process of crops treating, the remaining formulations have a sufficient selectivity of action in inhalation intake. In addition, it should be noted that in general, for all combined preparations CSA values are significantly lower than for separateactive ingredients, in addition to the above assumption, can be explained by the presence of other formulants in the preparation that may have not significant but toxic effect on the body of workers. All investigated substances in the probability of occurrence of acute poisoning with the use of combined preparations on their basis are related to the 4th grade of danger according to State Standards 8.8.1.002-98. There was proved relative safety in case of penetration into the organism of agricultural workers by percutaneous and inhalational way of all studied active ingredients and most of the formulations on their basis.
References
Balan GM, Kharchenko OA, Bubalo NM. [Reasons, structure and clinical symptoms of acute poisoning with pesticides in agricultural workers in terms of agriculture reform]. Suchasnі problemi toksikologії, kharchovoї ta khіmіchnoї bezpeki. 2013;4:22–29. Ukrainian.
[Hygienic classification of pesticides according to the degree of danger]: DSanPiN 8.8.1.002-98. [Approv. 28.08.98]. Кyiv: Ministry of health ofUkraine, 1998;20. Ukrainian.
Gornostay OB. [The development of occupational diseases inUkraine]. Naukoviy vіsnik NLTU Ukraїni. 2013;23(16):396-401. Ukrainian.
StorchousI.[Ecology and pesticides]. Available from: http://www.agro-business.com.ua/agronomiia-siogodni/838-ekologiia-i-pestytsydy.html. Ukrainian.
Kharchenko OA, Balan GM,BabichVA, et al. [Acute pesticide poisoning in the structure of occupational morbidity in agricultural workers]. Suchasnі problemi toksikologії. 2011;5:150-151. Russian.
[Official Site of Social Insurance Fund from industrial accidents and occupational diseasesUkraine]. Available from: http://www.social.org.ua. Ukrainian.
Sergeev SG, Chayka YuG. [Assessment of the possibility of acute toxic effects when working with pesticides, taking into account their selectivity of action]. Suchasni problemy toksykolohiyi. 2008;4:29-31. Russian.
Sokolova MP. [Problems of identification and registration of occupational diseases inUkraine], [dissertation]. Kyiv, 2009;20. Ukrainian.
Stavnіchenko PV, Antonenko AM, Korshun MM, et al. [Toxicological and hygienic regulation and hazard evaluation of a new fungicide – cyflufenamide]. Medicnі perspektivi. 2016;XXI(2):106-11. Ukrainian.
Downloads
How to Cite
Issue
Section
License
Copyright (c) 2017 Medicni perspektivi (Medical perspectives)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.