Morphometric analysis of pancytokeratin-negative neoplastic damages of the lymphatic nodes of the neck.
DOI:
https://doi.org/10.26641/2307-0404.2018.1.124915Keywords:
lymph nodes of the neck, immunohistochemistry, morphometry, ImageJAbstract
Patients with a diagnosis of cancer with an unknown primary localization (CUPL) are mostly referred to the category of cancer cohort with the clinical manifestation of lymph nodes enlargement. Cases of CUPL occupy 3-5% of all neoplasia of any localization, and only 20% of them have prognostically better chances as compared to other 80%. Materials and methods. The retrospective study 41 observations of the neoplastic lymph nodes in the neck without other clinical manifestations of primary tumor localization during was performed August 2016 - July 2017. The average age of patients was 47.68±16.41 years (median 46). The aim of the study was to analyze the complex of morphological, morphometric and immunohistochemical characteristics of Cytokeratin, Ran negative phenotypes of neoplastic lesions of lymph nodes of the neck for the improvement of diagnostic algorithms. Results. The authors have adjusted the objective parameters of nuclei of tumor cells (area, perimeter, coefficient of "roundness"), in comparison with the size of ordinary lymphocytes, the dependence of the size of the nuclei on morphological characteristics and the immunophenotype of the neoplastic damage of the lymph nodes of the neck has been analyzed.
References
Poslavskaya OV. [Determination of linear dimensions and square square surfaces areas of morphological objects on micrographs using ImageJ software]. Morphologia. 2016;10(3):377-81. Ukrainian.
Poslavska OV. [Methodology for the use of software for the analysis of digital micrographs on the base of pathomorphology course in order to increase the professional level of students and scientists]. Morphologia. 2015;9(3):122-6. Ukrainian.
Carollo A, Rosenkranz T, Smith DJ. Cancer of unknown primary (CUP) presenting as a Spigelian hernia: a case report. J Surg Case Rep. 2017;2017(4):rjw218.
Greco FA, Lennington WJ, Spigel DR, Varadhachary GR, Hainsworth JD. Carcinoma of Unknown Primary Site: Outcomes in Patients with a Colorectal Molecular Profile Treated with Site Specific Chemotherapy. Journal of Cancer Therapy. 2012;3:37-43.
Fletcher CDM. author. Diagnostic histopathology of tumors. 4th ed. PA: Elsevier. 2013;1148.
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-74.
Vajdic CM, Schaffer AL, Dobbins TA, Ward RL, Er CC, Pearson SA. Health service utilisation and investigations before diagnosis of cancer of unknown primary (CUP): A population-based nested case-control study in Australian Government Department of Veterans' Affairs clients. Cancer Epidemiol. 2015;39(4):585-92.
Lin F, Haiyan Liu. Immunohistochemistry in Undifferentiated Neoplasm / Tumor of Uncertain Origin. Arch Pathol Lab Med. 2014;138:1583-610.
Downloads
How to Cite
Issue
Section
License
Copyright (c) 2018 Medicni perspektivi
This work is licensed under a Creative Commons Attribution 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.
