Cytokine profile in patients with early latent syphilis.

S. V. Zakharov

doi:10.26641/2307-0404.2018.1.124933

Authors

S. V. Zakharov

DOI:

https://doi.org/10.26641/2307-0404.2018.1.124933

Keywords:

early latent syphilis, interleukin 6, interleukin 10

Abstract

The purpose of this study was to study the change in the content of the most active cytokines (interleukins 6 and 10) during the formation of the immune response in patients with latent early syphilis, as well as to study the possible relationship between the concentrations of these cytokines and the duration of the disease. In 50 patients with early latent syphilis, the concentration of interleukins 6 and 10 in serum was studied. The serum level of interleukins was studied by the enzyme immunoassay. A statistically significant increase in the concentration of interleukin 6 in the blood of patients with latent syphilis and decrease in the interleukin 10 concentration in comparison with healthy people was established. At the same time, in patients with latent syphilis with term of infection for more than 1 year, interleukin 10 has been expressed, as compared with healthy people and, especially, with patients with syphilis with a duration of infection of up to 1 year. Along with this, a lower degree of increase in the concentration of interleukin 6 in patients with latent syphilis with a duration of infection over 1 year has been established, as compared with patients with latent syphilis with a term of infection up to 1 year, against the background of its increased concentration as compared with a group of healthy individuals.

Author Biography

S. V. Zakharov

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of Skin and Veneral diseases
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

References

Burmester G –R, Petsutto A. [Visual immunology]. Мoskva, Binom. 2014;320.

DmitrievGA,FrigoNV. [Syphilis. Differential clinical-laboratory diagnosis]. Meditsinskaya kniga. 2004;363. Russian.

Zakharov VK, Dyudyun AD, Zakharov SV. [Hidden syphilis]. Dnipropetrovsk. 2011;119. Ukrainian.

Zaharov SV, Zaharov VK, Djudjun AD. [Features of the level of interleukin-6 inpatients with latent syphilis. Conference “Dermatovenereology in the aspect of a family doctor”]. Kyiv, 2008;35. Ukrainian.

Kamyshnikov VS. [Handbook of Clinical and Chemical Laboratory Diagnostics]. Мoskva, MEDpres-inform. 2009;896. Russian.

Mavrov GI, Shherbakova JuV. [The role of cytokines in the pathogenesis of latent syphilis. Conference “Actual problems of dermatology and venereology”].Odessa. 2003;75-77. Russian.

Mіntser OP, Voronenko YuV, Vlasov VV. [Treatment of clinical and experimental data in medicine: a manual]. Кyiv, Vyshha shkola. 2003;350. Ukrainian.

Shherbakova JuV. [Cytokines in the pathogenesis of latent syphilis. Conference “Contribution of young scientists to medical science”]. Harkіv. 2003;70-71. Ukrainian.

Carlson JA, Dabiri G, Cribier B, Sell S. The immunopathobiology of syphilis: the manifestations and course of syphilis are determined by the level of delayed-type hypersensitivity. Am. Dermatopathol. 2011;33(5):433-60.

Dinarello C. Proinflammatory cytoсines. Chest. 2000;118(9):503-8.

Kenyon C, Osbak KK, Crucitti T, Kestens L. The immunological response to syphilis differs by HIV status; a prospective observational cohort study. BMC Infectious Diseases. 2017;17:111-9.

Knudsen A, Benfield T, Kofoed K. Cytokine expression during syphilis infection in HIV-1-infected individuals. Sex Transm Dis. 2009;36(5):300-4.

Lusiak M, Podwińska J. Interleukin 10 and its role in the regulation of the cell-mediated immune response in syphilis. Arch Immunol Ther Exp. 2001;49(6):417-21.