Molecular-genetic testing of single-nucleotide polymorphism C-33T of IL4 gene in children with recurrent episodes of acute obstructive bronchitis.

Authors

  • O. V. Kens
  • O. Z. Gnateyko
  • N. S. Lukyanenko
  • V. I. Bergtravm

DOI:

https://doi.org/10.26641/2307-0404.2018.1(part1).127212

Keywords:

molecular genetic testing, children, IL4 gene C-33T polymorphism, repeated episodes of acute obstructive bronchitis

Abstract

The molecular genetic testing of the IL4 gene of a single nucleotide polymorphism C-33T was performed in 35 children with recurrent episodes of acute obstructive bronchitis and 35 children with acute bronchitis. It has been proved that the presence of a child's genotype 33СT IL4 increases the risk of recurrent acute obstructive bronchitis by 4 times.

Author Biographies

O. V. Kens

SI "Institute of hereditary pathology of the National academy of medical sciences of Ukraine"
Lysenko str., 31a, Lviv, 79008, Ukraine

O. Z. Gnateyko

SI "Institute of hereditary pathology of the National academy of medical sciences of Ukraine"
Lysenko str., 31a, Lviv, 79008, Ukraine

Lviv National Medical University named after D. Halytskyi 2
Department of propedeutics of pediatrics and medical genetics
Pekarska str., 69, Lviv, 79010, Ukraine

N. S. Lukyanenko

SI "Institute of hereditary pathology of the National academy of medical sciences of Ukraine"
Lysenko str., 31a, Lviv, 79008, Ukraine

Lviv National Medical University named after D. Halytskyi 2
Department of propedeutics of pediatrics and medical genetics
Pekarska str., 69, Lviv, 79010, Ukraine

V. I. Bergtravm

Municipal Institution Regional Children's Clinical Hospital "OKHMATDYT"
Lysenko str., 31, Lviv, 79008, Ukraine

References

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Yang HJ. Association between the interleukin-4 gene C-589T and C-33T polymorphisms and asthma risk: a meta-analysis. Med Res Arch. 2013;44:127-35.

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How to Cite

1.
Kens OV, Gnateyko OZ, Lukyanenko NS, Bergtravm VI. Molecular-genetic testing of single-nucleotide polymorphism C-33T of IL4 gene in children with recurrent episodes of acute obstructive bronchitis. Med. perspekt. [Internet]. 2018Apr.24 [cited 2024Dec.25];23(1(part1):67-71. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/127212

Issue

Vol. 23 No. 1(part1) (2018)

Section

CLINICAL MEDICINE

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