Function of external respiration in patients after kidney transplantation under conditions of immunosuppressive therapy.

Authors

  • O. V. Kuryata
  • O. O. Shtepa
  • O. V. Halushchak

DOI:

https://doi.org/10.26641/2307-0404.2018.1(part1).127245

Keywords:

function of external respiration, kidney transplantation, immunosuppressive therapy, cyclosporine, tacrolimus

Abstract

The aim of our study was to evaluate the changes in the parameters of the function of external respiration in patients after kidney transplantation due to chronic kidney disease and to assess the relationship between the level of cyclosporin A and tacrolimus in the blood with FVD indices. The study included 37 patients after kidney transplantation. The first group included 27 patients who received cyclosporine at an average dose of 225 [175-350] mg/day under the immunosuppressive therapy regimen, the second group included 10 patients who received tacrolimus at an average dose of 8.25 [5.0-9.0] mg/day. A significant difference (p˂0.05) between the indicators of the VCmax (78 [71-90]% and 76.5 [72-78]%), FVC (93 [85-99]% and 95 [91-98]%), PEF (82 [64-94]% and 80 [69-84]%), MEF25-75 (75 [66-112]% and 82.5 [67-90]%) was found in patients of the first and second groups relative to the FVD of the comparison group: VCmax (102.5 [98-113]%), FVC (107.5 [105.5-124]%), PEF (99.5 [95-102.5]%), MEF25-75 (98.5 [97.5-101.5]%). In both groups, a statistically significant negative correlation between the indicators of the VCmax, FVC and the level of cyclosporin A (R=-0.69, p<0.0001 and R=-0.4, p<0.037) in the blood in the first group and FVC and tacrolimus (R=-0.72, p<0.018) in the second group was found. A moderate decrease in the VCmax values in patients after kidney transplantation requires monitoring of the function of external respiration and managing such patients by nephrologists together with specialists in the pulmonological profile.

Author Biographies

O. V. Kuryata

SE “Dnipropetrovsk medical academy of Health Ministry of Ukraine” 1
Department of іnternal medicine 2
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

O. O. Shtepa

SE “Dnipropetrovsk medical academy of Health Ministry of Ukraine” 1
Department of іnternal medicine 2
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

O. V. Halushchak

ME “Dnipropetrovsk Regional Clinical Hospita. named after I.I. Mechnikov” 2
Department dialysis (hemodialysis and chronic ambulatory hemodialysis)
Soborna sq., 14, Dnipro, 49005, Ukraine

References

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How to Cite

1.
Kuryata OV, Shtepa OO, Halushchak OV. Function of external respiration in patients after kidney transplantation under conditions of immunosuppressive therapy. Med. perspekt. [Internet]. 2018Apr.24 [cited 2024Nov.23];23(1(part1):95-101. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/127245

Issue

Vol. 23 No. 1(part1) (2018)

Section

CLINICAL MEDICINE

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