Function of external respiration in patients after kidney transplantation under conditions of immunosuppressive therapy.

Authors

  • O. V. Kuryata
  • O. O. Shtepa
  • O. V. Halushchak

DOI:

https://doi.org/10.26641/2307-0404.2018.1(part1).127245

Keywords:

function of external respiration, kidney transplantation, immunosuppressive therapy, cyclosporine, tacrolimus

Abstract

The aim of our study was to evaluate the changes in the parameters of the function of external respiration in patients after kidney transplantation due to chronic kidney disease and to assess the relationship between the level of cyclosporin A and tacrolimus in the blood with FVD indices. The study included 37 patients after kidney transplantation. The first group included 27 patients who received cyclosporine at an average dose of 225 [175-350] mg/day under the immunosuppressive therapy regimen, the second group included 10 patients who received tacrolimus at an average dose of 8.25 [5.0-9.0] mg/day. A significant difference (p˂0.05) between the indicators of the VCmax (78 [71-90]% and 76.5 [72-78]%), FVC (93 [85-99]% and 95 [91-98]%), PEF (82 [64-94]% and 80 [69-84]%), MEF25-75 (75 [66-112]% and 82.5 [67-90]%) was found in patients of the first and second groups relative to the FVD of the comparison group: VCmax (102.5 [98-113]%), FVC (107.5 [105.5-124]%), PEF (99.5 [95-102.5]%), MEF25-75 (98.5 [97.5-101.5]%). In both groups, a statistically significant negative correlation between the indicators of the VCmax, FVC and the level of cyclosporin A (R=-0.69, p<0.0001 and R=-0.4, p<0.037) in the blood in the first group and FVC and tacrolimus (R=-0.72, p<0.018) in the second group was found. A moderate decrease in the VCmax values in patients after kidney transplantation requires monitoring of the function of external respiration and managing such patients by nephrologists together with specialists in the pulmonological profile.

Author Biographies

O. V. Kuryata

SE “Dnipropetrovsk medical academy of Health Ministry of Ukraine” 1
Department of іnternal medicine 2
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

O. O. Shtepa

SE “Dnipropetrovsk medical academy of Health Ministry of Ukraine” 1
Department of іnternal medicine 2
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

O. V. Halushchak

ME “Dnipropetrovsk Regional Clinical Hospita. named after I.I. Mechnikov” 2
Department dialysis (hemodialysis and chronic ambulatory hemodialysis)
Soborna sq., 14, Dnipro, 49005, Ukraine

References

Goreyov VA, Kaabak MM, Babenko NN. [Influence of the protocol of induction immunosup­pressive therapy on the state of the allotransplanted kidney]. Transplantologiya. 2017;1(9);7-11. Russian.

Kuryata OV, Cherkasova AV. [Arterial hyperten­sion in chronic kidney disease]. Dnipropetrovsk, Gerda. 2014;79. Russian.

Kuryata OV, Frolova EO. [Lipid metabolism and cardiovascular risk in patients with chronic kidney di­sease]. Dnіpropetrovsk, «Gerda». 2013;111. Ukrainian.

Pertseva TO, Kіreeva TV, Shtepa OO. [The in­fluence of comorbid pathology on expressiveness of in­flammantory process in patients with lower respiratory tract infections]. Zaporozhye medical journal. 2015;4(91):21-25. Ukrainian.

Pertseva TO, Kіreeva TV, Shtepa OO. [The ef­fecti­veness and necessity of carrying out ethiological diagnostics in patients with liwer respiratory tract in­fections]. Problemi ekologії ta meditsini. 2014;18(1-2):17-25. Ukrainian.

Pertseva TA, Konopkina LI. [Fundamentals of the study of the ventilation function of the lungs: clinical and diagnostic value. Methodical manual for doctors and stu­dents of medical schools].Dnepropetrovsk, «Art-Press». 2008;66. Russian.

Gabriel M Danovich. [Transplantation of the kid­ney]. Moysyuka YaG. editor. Moskva «GEOTAR- Me­dia». 2013;845. Russian.

Canet E, Osman D, Lambert V, et al. Acute res­piratory failure in kidney ransplant recipients: a multi­center study. Critical Care. 2011;15(91):2-10.

Cury JL, Brunetto AF, Aydon RD. Negative ef­fects of chronic kidney failure on lung function and fun­ctional capacity. Rev Bras Fisioter. 2010;14 (2):91-98.

Pencheva V, Petrova D, Genov D, Georgiev O. Pulmonary Complications as a Cause of Death after Renal Transplantation. Open Journal of Internal Medicine 2014;4:41-46.

Kupeli E, Ulubay G, Colak T, et al. Pulmonary Complications in Renal Recipients after Transplantation. Transplantation Proceedings. 2011;43:551-3.

Canadian Organ Replacement Register. 2011 re­port. Ottawa: Canadian Institute for Health Information; 2013.

Downloads

How to Cite

1.
Kuryata OV, Shtepa OO, Halushchak OV. Function of external respiration in patients after kidney transplantation under conditions of immunosuppressive therapy. Med. perspekt. [Internet]. 2018Apr.24 [cited 2024Dec.25];23(1(part1):95-101. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/127245

Issue

Vol. 23 No. 1(part1) (2018)

Section

CLINICAL MEDICINE

License

Copyright (c) 2018 Medicni perspektivi

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.

Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.