The influence of non-alcoholic fatty liver disease on the state of the macrophagal phagocytosis system in patients with community-acquired pneumonia.

Authors

  • R. V. Razumnyi

DOI:

https://doi.org/10.26641/2307-0404.2018.1(part1).127250

Keywords:

community-acquired pneumonia, fatty liver disease, hepatic steatosis, macrophage phagocyted system

Abstract

More and more attention of researchers is at­tracted by the so-called "syndrome of mutual burdening" in combined (comorbid) pathology. The aim of the study was to analyze the effect of nonalcoholic fatty liver disease on the functional state of the macrophagal phagocytic system (MPS) in patients with community-acquired pneumonia (CAP). 85 patients with CAP of III-IV clinical group aged 18-55 years were examined. All patients were divided into two representative groups: group I (44 patients) who had CAP comorbid with hepatic steatosis (HS), group ІІ (41 patients) without chronic liver pathology. For evaluation of the functional activity of MPS, phagocytic activity of peripheral blood monocytes with analysis of phagocytic index (FI), phagocytic number (FN), index of attraction (IA) and index of digestion (ID) was studied. The results of the study revealed that in the acute period of CAP, more expressed decrease in the capacity of monocytes/macrophages to phagocytosis, the incompleteness of the phagocytic reaction, and in general, the decline in the functional activity of MPS was observed in patients with CAP comorbid with HS. After the completion of the standard treatment of patients with CAP combined with HS, moderate disturbances in the functional activity of MPS persisted. On the assumption of findings, it can be advisable to consider a further study of the effectiveness of immunotropic medicines usage, with the purpose of correcting MPS disturbances in the complex treatment and medical rehabilitation of patients with CAP comorbid with HS.

Author Biography

R. V. Razumnyi

SE "Dnipropetrovsk Medical Academy of Health Ministry of Ukraine"
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

References

Abragamovych OO, Fajura OP, Abragamo­vych UO. [Comorbidity: a modern look at the problem; clicks (message first)]. L'vivs'kyj klinichnyj visnyk. 2015;1(9):56-64. Ukrainian.

Jelizarova TO, Kuznjecova LV. [Indices of pha­gocytic activity of monocytes in patients with non-alco­holic steatohepatitis]. Ukrai'ns'kyj morfologichnyj al'ma­nah. 2010;8(4):64-66. Ukrainian.

Zajchenko OE. [Therapeutic targets for non-alco­holic liver disease]. Suchasna gastroenterologіja. 2014;1(75):130-8. Russian.

Plehova NG, Kodrashova NM, Gel'cer BI, Ko­tel'nikov VN. [Cell-molecular factors of congenital pro­tection and their role in the pathogenesis of pneumonia]. Immunologija. 2017;38(2):124-9. Russian.

MedikVA, Tokmachev MS. [Mathematical sta­tistics in medicine: Textbook. allowance]. Moskva, Finan­sy i statistika, 2007;800. Russian.

Feshhenko JuІ, Belosludceva KO, Golubo­vs'ka OA, Gumenjuk MІ. [Untreated pneumonia in adults: etiology, pathogenesis, classification, diagnosis, antibac­terial therapy and prevention. A unified protocol for the provision of medical care to adult patients with com­munity-acquired pneumonia]. Nac. akad. med. nauk Uk­raїni, 2016;108. Ukrainian.

[Comparative data on the prevalence of respi­ratory diseases and medical care for patients with pulmonologic and allergic diseases inUkrainefor 2010-2016]. Centr med. statistiki Ukraїni MOZ Ukraїni, 2017;45. Ukrainian.

[About the approval of clinical protocols for the provision of medical care in the specialty "Pulmonology": Order of the Ministry of Health of Ukraine N 128 dated March 19, 2007]. Kyiv, 2007;146. Ukrainian.

SkibchikVA,VojtovichMO.[Non-alcoholic fat­ty liver disease: modern diagnosis]. Gepatologіja. 2015;1:52-56. Ukrainian.

Frolov VM. [Determination of phagocytic activity of peripheral blood monocytes in patients]. Laboratornoe delo. 1990;9:27-29. Russian.

Chugaj OO, Ljubіnec' LA. [Phagocytic activity of leukocytes in the dynamics of the development of experimental pneumonia]. Svіt medicini ta bіologії. 2017;2(60):172-4. Ukrainian.

Jagmur VB. [Non-alcoholic fatty liver disease: a modern look at pathogenesis, diagnosis and treatment]. Gastroenterologіja. 2013;3(49):138-47. Ukrainian.

AraújoAR, Rosso N, Bedogni G, Tiribelli C, Bel­lentani S. Global epidemiology of non-alcoholic fatty li­ver disease/non-alcoholic steatohepatitis: What we need in the future. Liver Int. 2018;38Suppl1:47-51.

Kolditz M, Ewig S. Community-Acquired Pneu­monia in Adults. Dtsch Arztebl Int. 2017;114(49):838-48.

Krenkel O, Tacke F. Macrophages in Nonal­co­holic Fatty Liver Disease: A Role Model of Pathogenic Im­munometabolism. Semin Liver Dis. 2017;37(3):189-97.

Sookoian S, Pirola CJ. Nonalcoholic Fatty Liver Disease Progresses into Severe NASH when Physio­logical Mechanisms of Tissue Homeostasis Collapse. Ann Hepatol. 2018;17(2):182-6.

Valderas JM, Sibbald B, Salisbury C. Defining Comorbidity: implications for understanding health and health services. Ann Fam Med. 2009;7:357-63.

Waterer GW. Community-acquired Pneumonia: A Global Perspective. Semin Respir Crit Care Med. 2016;37(6):799-805.

How to Cite

1.
Razumnyi RV. The influence of non-alcoholic fatty liver disease on the state of the macrophagal phagocytosis system in patients with community-acquired pneumonia. Med. perspekt. [Internet]. 2018Apr.24 [cited 2024Jul.20];23(1(part1):123-9. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/127250

Issue

Section

CLINICAL MEDICINE