Experience in managing patients with Churg-Strauss syndrome.

Authors

  • A. A. Khanyukov
  • Т. V. Lakiza
  • Т. А. Simonova
  • L. S. Pryazhnikova
  • V. Yu. Poleshko
  • N. A. Romuz

DOI:

https://doi.org/10.26641/2307-0404.2018.1(part1).127252

Keywords:

Churg-Strauss syndrome, diagnosis, treatment

Abstract

Our goal was to analyze the possibilities of impro­ving the diagnostics of CSS and to improve the effectiveness of treatment according to the existing literature and our own experience of long-term care for patients with eosinophilic granulomatosis with polyangiitis or Churg-Strauss syndrome (CSS). The medical histories of three female patients aged 26 to 46-years and a 20-year-old male patient were considered. The duration of the disease before the established diagnosis was 5-17 years. Anamnesis and medical documents analysis showed a typical CSS debut in the form of allergic rhinitis, nasal polyps, which were recurrent after polypectomy, and respiratory disorders, which were regarded as bronchitis or bronchial asthma – corresponding to the first phase, also called the prodromal or allergic stage of CSS. The prodromal period lasts up to 10 years or more and is characterized by various allergic manifestations, more often –  pollinosis or bronchial asthma, that is difficult to control. But CSS can be suspected because of low effectiveness of the therapy with inhaled steroids, lack of effect of antibiotics and eosinophilia more than 10% that occurs periodically. Even in the third stage of CSS in systemic manifestations of vasculitis and severe secondary lesions of organs and tissues with functional impairment, constant intake of maintenance doses of corticosteroids and cytostatics allows to achieve stabilization of the process in patients with CSS.

Author Biographies

A. A. Khanyukov

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» *
Department of internal medicine 3
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

Т. V. Lakiza

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» *
Department of internal medicine 3
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

Т. А. Simonova

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» *
Department of internal medicine 3
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

L. S. Pryazhnikova

«Dneprovsky Clinical Hospital on the railway transport of the Branch» Health Center «PAO» Ukrainian Railway» **
D. Kedrina str., 55, Dnіprо, 49047, Ukraine

V. Yu. Poleshko

«Dneprovsky Clinical Hospital on the railway transport of the Branch» Health Center «PAO» Ukrainian Railway» **
D. Kedrina str., 55, Dnіprо, 49047, Ukraine

N. A. Romuz

«Dneprovsky Clinical Hospital on the railway transport of the Branch» Health Center «PAO» Ukrainian Railway» **
D. Kedrina str., 55, Dnіprо, 49047, Ukraine

References

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How to Cite

1.
Khanyukov AA, Lakiza ТV, Simonova ТА, Pryazhnikova LS, Poleshko VY, Romuz NA. Experience in managing patients with Churg-Strauss syndrome. Med. perspekt. [Internet]. 2018Apr.24 [cited 2024Jun.24];23(1(part1):136-40. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/127252

Issue

Section

CLINICAL MEDICINE