Dynamics of cumulating of metronidazole in the gut wall on a model of mechanical ileus.
DOI:
https://doi.org/10.26641/2307-0404.2018.4(part1).145678Keywords:
acute obstruction of the intestine, experimental ileus, metronidazole, cumulation of antibacterial drugsAbstract
The frequency of acute intestinal obstruction in relation to urgent surgical diseases in Ukraine remains high and reaches 3.8-6%. In the postoperative period, such patients develop a high number of severe purulent-septic complications. For the prevention and treatment of purulent-septic complications, various combinations of antibiotics with metronidazole are used. On the model of experimental mechanical ileus, the ability of the modified bowel wall to retain metronidazole was determined. The experiment was performed on 20 lines of the "Vistar" line in which the mechanical model of the ileus was formed. The results of the study showed that the accumulation of metronidazole in the phlegmonous-altered gut wall at therapeutic concentrations occurs within the first 24 hours and is of a short-term nature. The lack of the possibility of cumulating of antibacterial drugs by the wall of the inflamed gut after 24 hours contributes to the development of purulent complications.
References
Boiko VV, Kryvorotko IV, Klimova EM, et al. [Analysis of the treatment of acute adhesive intestinal obstruction]. Khark. khirurg. shkola. 2013;5:5-8. Russian.
Bohun OA. [Prevention of purulent-septic complications in patients with acute intestinal obstruction]. Avt. Kharkiv; 2010. Ukrainian.
Boiko VV. [Diagnosis and treatment of patients with acute intestinal obstruction]. Kharkiv, KhNU VN Karazina. 2014;176. Ukrainian.
Yermolov AS, Yartsev PA, Lebedev AG, et al. [Diagnosis and treatment of acute surgical diseases of the abdominal cavity. The experience of Moscow public health in 1992-2014]. edit. Ermolov AS. Мoskva, Vidar. 2015;640. Russian.
Shaprynskyi VO, Kaminskyi OA, et al. [Comprehensive treatment of acute intestinal obstruction of non-tumorgenesis]. Khark. khir. shkola. 2014;2:62-65. Ukrainian.
Radzikhovskiy AP, Belyaeva OA, Kolesnikov EB, et al. [Bowel obstruction: a guide for doctors]. edit. Razdikhovskiy АP. Кyiv, Feniks. 2012;504. Russian.
[Manual of Clinical Surgery. Differential diagnosis and treatment of surgical diseases]. edit. Kondratenko PG. Donetsk. 2013;752. Russian.
Todurov IM, Belyanskiy LS, Manoylo NV, Perekhrestenko AV. [Modern principles and possibilities of surgical treatment of patients with acute obstruction of the large intestine]. Сonference «Urgent questions of urgent surgery». Khark. khirurg. shkola. 2008;2:290-5. Russian.
[Reference book "Compendium 2013 – medicines"]. Editor Kovalenko VN.. Кyiv, Morion. 2013;2360. Russian.
Akperov IA, Kalenich IS, Kosyakov BA, Shalkov YuL, et al. [Colonic ileus in the light of risk factors]. Khark. khirurg. shkola. 2012;3(54):23-25. Russian.
European Pharmacopoeia (Ph. Eur.) 9th Edition (EP 9.0); 2017.
Metronidazole. European Pharmacopoeia 9.0.; 3059.
Schwart́z Principles of Surgery, Ninth Edition. The McGraw-Hill. 2010;1888.
Downloads
How to Cite
Issue
Section
License
Copyright (c) 2018 Medicni perspektivi (Medical perspectives)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.