Determining the effect of cadmium on embryogenesis in isolated administration and in combination with selenium and germanium citrates
DOI:
https://doi.org/10.26641/2307-0404.2020.1.200395Keywords:
embryogenesis in rat, cadmium, germanium citrate, selenium citrate, liverAbstract
Cadmium compounds found in biological systems form the ecological crisis of the planet. An urgent task for researchers is to determine the morphological changes that occur in the body under the action of cadmium compounds in both prenatal and postnatal ontogenesis. The article discusses the results of effect of intragastric administration of cadmium chloride/cadmium citrate in isolation and in combination with selenium and germanium citrates on embryogenesis of pregnant female rats. The aspect of the accumulation of cadmium salts in the liver of a 20-day-old embryo by polyelement analysis was also studied. The use of multielement analysis showed that the highest level of cadmium accumulation in the liver of embryos was found in the group of isolated administration of cadmium chloride. It has been proven that cadmium citrate accumulates in the liver to a lesser extent than cadmium chloride in the liver. The accumulation of cadmium chloride with selenium citrates, germanium in the groups of combined administration showed a decrease in the cadmium content in the liver of embryos. An analysis of the basic indicators of embryonic development of the experiment proved the embryotoxic effect of cadmium salts during enteral administration in modeling chronic cadmium intoxication, which is expressed in a decrease in the number of embryos in the litter and an increase in embryonic mortality in relation to the control group at all studied developmental periods. A decrease in embryonic mortality and an increase in the number of embryos at all stages of gestation in the experiment with the combined administration of cadmium salts with germanium citrate and selenium citrate indicates their antagonistic effect on cadmium embryotoxicity.
References
Borisevich VB, Kaplunenko VG, Kosinov MV. [Nanomaterials in Biology. Fundamentals of nano-veterinary medicine]. Kyiv: VD Avicenna; 2010. p. 416
Tadzhikulova OD, Abdullaeva GT, Ergashev NA, Komilov ED, Asrarov MI, Kulkaraev AK. [The influence of heavy metals on the blood glucose and glycogen content of rat liver]. Universum: chemistry and biology. 2019;3(57):53-58. Russian.
Dinerman AA. [The role of environmental pollutants in the violation of embryonic development]. Moskva: Medicine; 1980. p. 191. Russian.
Shatornaya VF, Garets VI, Kononova II, Stepanov SV, Dikhno NI. [Combining effect of heavy metals on rat embryogenesis in experiment]. World of Medicine and Biology. 2014;4:170-4. Russian.
Garets VI, Shatorna VF, Ostrovskaya SS, Kononova II, Krasnov OO. [Methodical approaches to determination of embryotoxicity and teratogenicity of heavy metals in morphological experiments[. Ukrainian Journal of Medicine, Biology and Sports. 2015;1(1):189-94. Ukrainian.
Onul NM. [The content of trace elements in the body of the female and the fetus during physiological pregnancy and exposure to heavy metals]. Actual problems of modern medicine. 2014;14(3):235-8. Ukrainian.
Skalny AV. [Assessment and correction of the elemental status of the population is a promising area of domestic health care and environmental monitoring]. Microelements in medicine. 2018;19 (1):5-13. Russian.
Skalny AV, Zaitseva I P, Tinkov AA. [Microelements and sports. Personalized correction of the elemental status of athletes]. Moskva: Sport; 2018. p. 288. Russian.
Fedorenko VI. Substantiation of allowable daily doses of lead and cadmium in diets. Medical perspectives. 2019;24(1):73-80.
Shafran LM, Pikhtieva OG, Bolshoy DV. [An algorithm for laboratory tests for suspected dyshomeostasis of heavy metals]. Actual problems of transport medicine. 2014;1(4):97-105. Ukrainian.
Azad Gull, Ashaq Ahmad Dar, Manoj Sharma. Effects of Heavy Metals on the Health of Pregnant Women and Fetus: A Review. International Journal of Theoretical & Applied Sciences. 2018;10(1):01-09.
Lamas GA, Navas-Acien A, et al. Heavy metals, cardiovascular disease, and the unexpected benefits of edetate chelation therapy. J Am Coll. Cardiol. 2016;67:2411-8. doi: https://doi.org/10.1016/j.jacc.2016.02.066
Jacobo-Estrada Tania, Santoyo-Sánchez Mitzi, Thévenod Frank, Olivier Barbier. Cadmium Handling, Toxicity and Molecular Targets Involved during Pregnancy: Lessons from Experimental Models. International Journal of Molecular Sciences. 2017;18:136-55. doi: https://doi.org/10.3390/ijms18071590
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