Clinical course and risk prediction of permanent atrial fibrillation development in patients with chronic heart failure and mid-range ejection fraction of the left ventricle.

Authors

  • O. O. Khaniukov
  • M. I. Yalovenko
  • O. S. Kalashnykova
  • O. I. Kravchenko

DOI:

https://doi.org/10.26641/2307-0404.2020.2.206368

Keywords:

permanent atrial fibrillation, chronic heart failure with mid-range ejection fraction, clinical course, prognosis

Abstract

The purpose of the study was to establish clinical features of permanent atrial fibrillation (AF) in patients with heart failure mid-range ejection fraction (HFmrEF) and to develop a mathematical model for predicting arrhythmia development. The study included 42 patients with IHD, arterial hypertension (AH), permanent AF and HFmrEF (1 group), mean age – 68.0±1.2 years (21 men and 21 women) and 36 patients with CAD / АH and HFmrEF without AF, mean age- 67.5±0.7 years (22 men and 14 women). The results of the study show, that patients with permanent AF and HFmrEF are characterized by the higher diastolic arterial pressure, higher values of the LDLP, iESV LV, index of end-systolic volume of LV septal thickness and lower EF of the LV in comparison with patients without AF. Patients with permanent AF and HFmrEF also have increased plasma levels of hsCRP, IL-1β, IL-6 and IL-10 in comparison with patients without AF. A mathematical model with scoring system of hsCRP, IL-1β, LV mass index, HDLP, LDLP was developed to assess the risk of AF development in patients with HFmrEF with accuracy of 85.9%, sensitivity of 85.7% and  specificity of 86.1%.

Author Biographies

O. O. Khaniukov

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
DepartmentofInternalMedicine 3

M. I. Yalovenko

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
DepartmentofInternalMedicine 3

O. S. Kalashnykova

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
DepartmentofInternalMedicine 3

O. I. Kravchenko

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
DepartmentofInternalMedicine 3

References

Bubeshko DA, Snezhitskiy VA, Shulika VR. [Biomarkers of inflammation in patients with nonvalvular atrial fibrillation and left ventricular systolic dysfunction]. Med. news. 2017;4:69-72.

Voronkov LG, Ilnytska MR, Babich PM. [The prognosis of patient with chronic heart failure and left ventricular systolic depending on the data noninvasive method examination]. Ukr. therap. j. 2010;2:33-39.

Odutayo A, Wong CX, Hsiao AJ, et al. Atrial fibrillation and risks of cardiovascular disease, renal disease, and death: systematic review and meta-analysis. Bmj. 2016;354:448-54. doi: https://doi.org/10.3389/fneur.2017.00668

Startipy U, Dahlström U, Fu M, et. al. Atrial Fib­ril­lation in heart failure with preserved, mid-range, and reduced ejection fraction. JACC: heart failure. 2017;5(8):565-74. doi: https://doi.org/10.1016/j.jchf.2017.05.001

Schnabel R, Pecen L, Engler D, et al. Atrial fibrillation patterns are associated with arrhythmia pro­gression and clinical. Heart. 2018;34(5):24-36. doi: https://doi.org/10.1136/heartjnl-2017-312569

Batul SA, Gopinathannair R. Atrial Fibrillation in Heart Failure: a Therapeutic Challenge of Our Times. Korean Circ. J. 2017;47(5):644-62. doi: https://doi.org/10.4070/kcj.2017.0040

McMurray JJ, Adamopoulos S, Anker SD, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Eur. Heart J. 2012;33:1787-847. doi: https://doi.org/10.1093/eurheartj/ehs104

Ponikowski P, Voors AA, Anker SD, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diag­nosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure As­sociation (HFA) of the ESC. Euro. Heart J. 2016;37(27):2129–200. doi: https://doi.org/10.1093/eurheartj/ehw128

Kirchhof P, Benussi S, Kotecha D, et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Euro. Heart J. 2016;37(38):2893-962. doi: https://doi.org/10.5603/KP.2016.0172

Global Burden of Disease Collaborative Network (2016) Global Burden of Disease Study 2016 (GBD 2016) Results. Institute for Health Metrics and Evaluation (IHME). Seattle, United States; 2017. Available from: http://ghdx.healthdata.org/gbd-results-tool

Mitchell C, Rahko PS, Blauwet LA, et. al. Guide­lines for performing a comprehensive transthoracic echocardiographic examination in adults: recom­men­dations from the American Society of Echocar­diogra­phy 2019. J. of the Am. Soc. of Echocard. 2019;32(1):1-64. doi: https://doi.org/10.1016/j.echo.2018.06.004

Yang Song NEI, Cannon CP, Doros G, et. al. Heart failure with mid-range ejection fraction: characte­rization of patients from the PINNACLE Registry®. 2019;6(4):784-92. doi: https://doi.org/10.1002/ehf2.12455

Ballatore A, Matta M, Saglietto A, et. al. Subcli­nical and Asymptomatic Atrial Fibrillation: Current Evidence and Unsolved Questions in Clinical Practice. Medicina. 2019;55(8):497. doi: https://doi.org/10.3390/medicina55080497

Verma JM, Kalman. DJ. Callans. Treatment of Pa­tients With Atrial Fibrillation and Heart Failure With Re­duced Ejection Fraction. Circulation. 2017;136(16):1547-63. doi: https://doi.org/10.1161/CIRCULATIONAHA.116.026054

How to Cite

1.
Khaniukov OO, Yalovenko MI, Kalashnykova OS, Kravchenko OI. Clinical course and risk prediction of permanent atrial fibrillation development in patients with chronic heart failure and mid-range ejection fraction of the left ventricle. Med. perspekt. [Internet]. 2020Jul.1 [cited 2024Jun.15];25(2):78-85. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/206368

Issue

Section

CLINICAL MEDICINE