Weight of the thyroid, adrenal glands, and the liver of white rats in the conditions of hyperthyroidism: the possibility of applying indices changes as screening-markers for determining body status effected by organic and inorganic iodine.





оrgan weight, thyroid gland, adrenal glands, liver, hyperthyroidism


Despite the available information on the interaction between the thyroid gland activity and that of the adrenal glands, and the liver involvement in their hormones metabolism, the study of the connection existing between these organs in hyperthyroidism is still incomplete. Changes in the weight indices values of the thyroid and adrenal glands and the liver of 90 non-linear white male rats were studied. Animals received histologically verified minimally active (21 μg iodine per kg body weight), moderate (50 μg iodine per kg body weight), and significant (100 μg iodine per kg body weight) doses of organic and inorganic iodine during 30 days under the model hyperthyroidism conditions. It was found that consumption of organic and inorganic iodine at a minimal dose approximates the digital values of adrenal gland and those of the liver of the intact animals. Consumption of a moderate organic iodine dose is accompanied by a decrease in the previously achieved values of the thyroid weight index by 17.28%, and the increase in the liver weight index by 19.66%. When consuming a moderate amount of inorganic iodine, the largest change in the values achieved was the liver weight index which increased by 13.76%. Consumption of organic and inorganic iodine compounds in a significant dose is accompanied by further changing in the studied parameters. When consuming organic iodine the thyroid weight index grows by 10.44%, that of the adrenal glands – by 13.33%, the liver – by 34.52%. Сonsuming of inorganic iodine is accompanied by a rapid increase in the thyroid glands weight index by 21.25%, that of the liver – by 34.31%. The established indicates the existence of functional communication between the studied organs; the effect depends on the chemical nature and dose of iodine consumed. The existing functional dependence gives grounds to apply changes in the weight index of the thyroid gland, adrenal glands and the liver as screening-markers to determine the body’s condition in hyperthyroidism.


Author Biography

O. I. Ryabukha

Lviv Medical Institute
Department of Аnatomy, Physiology and Pathology
Polishchuk str., 76, Lviv, 79018, Ukraine


Antomonov МYu. [Mathematical treatment and analysis of medico-biological data]. 2nd ed. Кyiv: Inter­regio­nal Publishing Center "Medinform"; 2017. p. 579 Russian.

Mubbunu L, Bowa K, Petrenko V, Silitongo M. Correlation of internal organ weights with body weight and body height in normal adult zambians: A case study of Ndola Teaching Hospital. Anat Res Int. 2018;2018:1-5. doi: https://doi.org/10.1155/2018/4687538

Devereaux D, Tewelde SZ. Hyperthyroidism and thyrotoxicosis. Emerg Med Clin N Am. 2014;32(2):277-92. doi: https://doi.org/10.1016/j.emc.2013.12.001

Ferlazzo A, Cravana C, Fazio E, Medica P. Is there an interplay between the hypothalamus-pituitary-thyroid and the hypothalamus-pituitary-adrenal axes du­ring exercise-stress coping in horses? J Equine Vet Sci. 2018;62:85-97. doi: https://doi.org/10.1016/j.jevs.2017.08.018

Malespin M, Nassri A. Endocrine Diseases and the Liver: An Update. Clin Liver Dis. 2019;23(2):233-246. doi: https://doi.org/10.1016/j.cld.2018.12.006

Mansourian AR. Liver functional behavior during thyrotoxicosis: a review. Journal of Biological Sciences. 2013;13(8):665-78. doi: https://doi.org/10.3923/jbs.2013.665.678

Manojlović-Stojanoski MN, Filipović BR, Nesto­rović NM, Šošić-Jurjević BT, Milošević VLj. Morpho-functional characteristics of rat fetal thyroid gland are affected by prenatal dexamethasone exposure. Steroids. 2014;84:22-9. doi: https://doi.org/10.1016/j.steroids.2014.03.006

Mullur R, Liu YY, Brent GA. Thyroid hormone regulation of metabolism. Physiol Rev. 2014;94(2):355-82. doi: https://doi.org/10.1152/physrev.00030.2013

Ranabir S, Reetu K. Stress and hormones. Indian J Endocrinol Metab. 2011;15(1):18-22. doi: https://doi.org/10.4103/2230-8210.77573

Ryabukha O, Dronyuk I. Applying regression analysis to study the interdependence of thyroid, adrenal glands, liver, and body weight in hypothyroidism and hyperthyroidism. Proceedings of the 2nd International Workshop on Informatics & Data-Driven Medicine (IDDM 2019). Lviv, Ukraine, November 11-13, 2019. CEUR Workshop Proceedings-Series. 2019;2488:155-164.

Ryabukha O, Greguš ml M. Correlation analysis as a thyroid gland, adrenal glands, and liver relationship tool for correcting hypothyroidism with organic and inorganic iodine. Procedia Comput Sci. 2019;160:598-603. doi: https://doi.org/10.1016/j.procs.2019.11.041

Ryabukha OI. Search for markers of changes of the synthetic activity of thyrocyte under the influence of iodine reception in iodine deficiency conditions. World of Medicine and Biology. 2018;65(3):179-85. doi: https://dx.doi.org/10.26724/2079-8334-2018-3-65-179-185

Sheikhazadi A, Sadr SS, Ghadyani MH, Taheri SK, Manouchehri AA, Nazparvar B et al. Study of the normal internal organ weights in Tehran’s population. J Forensic Leg Med. 2010;17(2):78-83. doi: https://doi.org/10.1016/j.jflm.2009.07.012

Caglar V, Kumral B, Uygur R, Alkoc O, Ozen O, Demirel H. Study of volume, weight and size of normal pancreas, spleen and kidney in adults autopsies. Forensic Medicine and Anatomy Research. 2014;2:63-9. doi: https://dx.doi.org/10.4236/fmar.2014.23012

Vanderpump MP. The epidemiology of thyroid disease. Br Med Bull. 2011;99(1):39-51. doi: https://doi.org/10.1093/bmb/ldr030


How to Cite

Ryabukha OI. Weight of the thyroid, adrenal glands, and the liver of white rats in the conditions of hyperthyroidism: the possibility of applying indices changes as screening-markers for determining body status effected by organic and inorganic iodine. Med. perspekt. [Internet]. 2020Jul.1 [cited 2024Jun.16];25(2):149-55. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/206793